IP Library › Granted Patent US 7,026,320
Granted Patent B2
US 7,026,320 · App. 10/441,536 · Granted Apr 11, 2006

Serotonergic agents

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Quick Facts
Patent No.
US 7,026,320
App. No.
10/441,536
Granted
Apr 11, 2006
Kind
B2
Abstract

Novel piperazine derivatives are provided having the formula wherein R 1 is cyano, nitro, trifluoromethyl or halogen, or pharmaceutically acceptable acid addition salts thereof, which are useful as 5-HT 1A receptor antagonists.

Claims (3)

1. A method for treating cognitive impairment in an Alzheimer's disease patient, the method comprising providing to the patient a therapeutically effective amount of a compound of formula (III):

wherein R 1 is cyano, nitro, trifluoromethyl or halogen, or pharmaceutically acceptable acid addition salts thereof.

2. The method of claim 1 , wherein the compound is (R)-4-cyano-N-{2-[4-(2,3-dihydro-benzo[1,4]dioxin-5-yl)piperazine-1-yl]-propyl}-N-pyridin-2-yl-benzamide.