Peptide derivatives, and their use for the synthesis of silicon-based composite materials
View Patent ↗Methods for forming peptide derivatives using functional moieties and peptide derivatives are provided. Further, methods for using peptide derivatives to form silicon-based composite materials and silicon-based composite materials formed thereby are provided. The silicon-based composite materials may have features on the nanoscale, and the materials may exhibit characteristics derived from the functional moieties on the peptide derivatives. It is emphasized that this abstract is provided to comply with the rules requiring an abstract which will allow a searcher or other reader to quickly ascertain the subject matter of the technical disclosure. It is submitted with the understanding that is will not be used to interpret or limit the scope or meaning of the claims.
1. A method of forming a composite material comprising:
providing a peptide selected from those having amino acid sequences of substantially SSKKSGSYSGSKGSKRRIL (SEQ ID NO: 1), SSKKSGSYSGYSTKKSGSRIL (SEQ ID NO: 2), LDAQERRRERRAEKQEQWKAAN (SEQ ID NO: 3), SSHKSGSYSGSHGSHRRIL (SEQ ID NO: 4), CSKKSGSYSGSKGSKRRC (SEQ ID NO: 5), SKKSGSKKSGSKKSGIL (SEQ ID NO: 6), RRRRRRRRR (SEQ ID NO 7) with an aminohexanoic acid linker, SKKSGSYYSYGTKKSGSYSGYSTKKSASRRIL (SEQ ID NO: 16), SKKSGSYSGSKGSKRRNL (SEQ ID NO: 17), PPGHHHWHIHH (SEQ ID NO: 18), MSASSYASFSWS (SEQ ID NO: 19), KPSHHHHHTGAN (SEQ ID NO: 20), MSPHPHPRHHHT (SEQ ID NO: 21), MSPHHMHHSHGH (SEQ ID NO: 22), LPHHHHLHTKLP (SEQ ID NO: 23), APHHHHPHHLSR (SEQ ID NO: 24), and RGRRRRLSCRLL (SEQ ID NO: 25);
modifying said peptide with a first functional moiety selected from the group consisting of 1-pyreneacetic acid, 1-pyrenemethylamine, 5(6)-carboxyfluorescein, EDTA, cyclam tetraacetic acid, lauric acid, cholesterol, D-biotin, carboxymethyl-β-cyclodextrin, and cysteine to form a peptide derivative; and
exposing said peptide derivative to a precursor containing a silicon species such that a composite material forms, wherein said peptide derivative and said silicon species are incorporated into said composite material.
2. The method of claim 1 wherein said peptide comprises substantially SSKKSGSYSGSKGSKRRIL (SEQ ID NO: 1).
3. The method of claim 1 wherein said peptide comprises substantially SSKKSGSYSGYSTKKSGSRIL (SEQ ID NO: 2).
4. The method of claim 1 wherein said peptide comprises substantially LDAQERRRERRAEKQEQWKAAN (SEQ ID NO: 3).
5. The method of claim 1 wherein said peptide comprises substantially SSHKSGSYSGSHGSHRRIL (SEQ ID NO: 4).
6. The method of claim 1 wherein said peptide comprises substantially CSKKSGSYSGSKGSKRRC (SEQ ID NO: 5).
7. The method of claim 1 wherein said peptide comprises substantially SKKSGSKKSGSKKKSGIL (SEQ ID NO: 6).
8. The method of claim 1 wherein said peptide comprises substantially RRRRRRRRR (SEQ ID NO: 7) with an aminohexanoic acid linker.