Methods of producing intraocular lenses
View Patent ↗Methods of producing an intraocular lens include introducing a solution into a lens forming enclosure, wherein the solution comprises discrete crosslinkable units of a size small enough to provide an optically clear solution while contributing to a high refractive index of at least 1.3, performing crosslinking between the units of the solution, and thereby forming a solid lens in the enclosure, optionally under a forming pressure.
1. A method of producing an intraocular lens including: (i) introducing a solution into a lens forming enclosure, said solution comprising discrete crosslinkable units comprising macromolecular particles of a size small enough to provide an optically clear solution while contributing to a high refractive index of at least 1.39; (ii) performing crosslinking between said units of the solution; and thereby (iii) forming a solid lens in said enclosure, optionally under a forming pressure.
2. A method according to claim 1 wherein said crosslinking is initiated by exposing a photoinitiator which is soluble in said solution to light.
3. A method according to claim 2 , wherein said crosslinkable units are macromolecular particles having a size range between about 20 to 160 nm.
4. A method according claim 2 , wherein said solution has a sufficiently low viscosity to be injected with a conventional cannula into said forming enclosure.
5. A method according to claim 1 , wherein the formed lens is an elastically deformable lens with a modulus in the range of about 0.1 to 20 kPa.
6. A method according to claim 2 , wherein said crosslinking reaction is initiated by light of a wavelength above about 305 nm.
7. A method according to claim 4 , wherein said solution is an ophthalmically acceptable aqueous solution.
8. A method according to claim 7 wherein the aqueous solution comprises a water soluble photoinitiator.
9. A method according to claim 8 , wherein the soluble photoinitiator comprises at least one photoactive compound attached to a water soluble macromolecule.
10. A method according to claim 3 , wherein said macromolecular particles are provided with functional groups for crosslinking.
11. A method according to claim 10 , wherein the functional groups comprise vinylic, acrylic or methacrylic groups.
12. A method according to claim 10 , wherein the macromolecular particles are water soluble.
13. A method according to claim 12 , wherein the macromolecular particles comprise units derived from vinyl lactams and/or acrylamides, of which at least one unit contributes to provide a solution of the particles with a refractive index of at least 1.39 and at least one unit contributes to provide the particles with hydrophilic overall characteristics.
14. A method according to claim 13 , wherein said vinyl lactam is N-vinylpyrrolidone.
15. A method according to claim 13 , wherein said acrylamide is N,N-dimethylacrylamide.