Diagnosis and treatment of disorders of iron metabolism
View Patent ↗The invention concerns a method for detecting disorders of iron metabolism and in particular the differential diagnosis of disorders of iron metabolism by means of three independent parameters. The differential diagnosis can be used to classify disorders of iron metabolism and to recommend the required treatment and to monitor the progress and response to treatment.
1. A method for identifying iron deficiency in a patient, the method comprising:
(a) determining a level of each of the following in one or more samples from a patient:
(i) ferritin,
(ii) sTfR, and
(iii) CHr;
(b) plotting sTfR/log ferritin on a first axis of a plot and CHr on a second axis of the plot, the plot divided into quadrants, the quadrants defining specific iron deficiency classifications of:
(1) no biochemical or haemotologically identified iron deficiency,
(2) biochemically identified iron deficiency,
(3) biochemical and haemotologically identified iron deficiency, and
(4) haemotologically identified iron deficiency; and
(c) determining the iron deficiency classification of the patient.
2. The method of claim 1 wherein the patient is classified as having (1) no biochemical or haemotologically identified iron deficiency or (2) biochemically identified iron deficiency when the level of CHr is equal to or greater than 28 pg/cell.
3. The method of claim 1 , wherein the patient is classified as having (3) biochemical and haemotologically identified iron deficiency or (4) haemotologically identified iron deficiency when the level of CHr is less than 28 pg/cell.