Preventives/remedies for inflammatory airway diseases
View Patent ↗A preventive and/or therapeutic agent for inflammatory respiratory tract diseases containing, as an active ingredient, a steroid derivative represented by the following formula (1): (wherein R represents a hydrogen atom, a halogen atom, a hydroxy group, or —OCOR 1 (wherein R 1 represents a linear or branched alkyl group which may be substituted by a halogen atom or a cycloalkyl group; a cycloalkyl group; or an aryl group)). These compounds can continuously suppress respiratory tract inflammation and respiratory tract hyperreaction and show a high site selectivity and little systemic effect when administered directly to the respiratory tract. By virtue of these characteristics, these compounds are remarkably useful in clinical medicine as highly safe preventive and/or therapeutic agents for inflammatory respiratory tract diseases which can be administered for a long period of time.
1. A method for treating an inflammatory respiratory tract disease, comprising administering a steroid derivative through peroral inhalation or intranasally, wherein the steriod derivative is represented by the following formula (1):
(wherein R represents a hydrogen atom, a halogen atom, a hydroxy group, or —OCOR 1 (wherein R 1 represents a linear or branched alkyl group which may be substituted by a halogen atom or a cycloalkyl group; a cycloalkyl group; or an aryl group)).
2. The method as described in claim 1 , wherein the steroid derivative is 9-fluoro-11β,17,21-trihydroxy-16α-methyl-1,4-pregnadiene-3,20-dione 17-cyclopropanecarboxylate or 9-fluoro-11β,17,21-trihydroxy-16α-methyl-1,4-pregnadiene-3,20-dione 21-cyclohexanecarboxylate 17-cyclopropanecarboxylate.
3. The method as described in claim 1 , wherein the inflammatory respiratory tract diseases is selected from the group consisting bronchial asthma, nasal hypersensitivity, laryngeal allergy, and sinusitis.
4. The method as described in claim 2 , wherein the inflammatory respiratory tract disease is selected from the group consisting of bronchial asthma, nasal hypersensitivity, laryngeal allergy, and sinusitis.
5. The method as described in claim 1 , wherein the steroid derivative is administered as a powder.
6. The method as described in claim 1 , wherein the steroid derivative is administered as a liquid.