Use of ramoplanin to treat diseases associated with the use of antibiotics
View Patent ↗The invention features a method of treating or preventing a disease associated with the use of antibiotics in a patient in need thereof by administering to the patient ramoplanin in an amount and for a duration effective to treat said disease. The disease may be caused, for example, by the presence of a bacterium such as enterotoxin producing strains of C. difficile, C. perfringens , or S. aureus.
1. A method of treating a patient with a Clostridium difficile -associated condition, said method comprising administering to said patient ramoplanin in an amount and for a duration effective to treat said condition, wherein said method is effective for reducing the population of Clostridium difficile and Clostridium difficile spores.
2. The method of claim 1 , wherein said Clostridium difficile is resistant to metronidazole and/or vancomycin.
3. The method of claim 1 , wherein said Clostridium difficile -associated condition is selected from the group consisting of antibiotic-associated diarrhea, colitis, and pseudomembranous colitis.
4. The method of claim 1 , wherein said ramoplanin is administered in an amount between 50 mg and 1 g.
5. The method of claim 4 , wherein said ramoplanin is administered in an amount between 200 and 400 mg once or twice daily.
6. The method of claim 1 , wherein said ramoplanin is administered one to four times daily for three to fifteen days.
7. The method of claim 1 , wherein said ramoplanin is administered orally.
8. The method of claim 1 , further comprising administering to said patient vancomycin, bacitracin, or metronidazole.