IP Library › Granted Patent US 8,034,332
Granted Patent B2
US 8,034,332 · App. 10/456,237 · Granted Oct 11, 2011

Interleukin-secreting natural killer cell lines and methods of use

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Quick Facts
Patent No.
US 8,034,332
App. No.
10/456,237
Granted
Oct 11, 2011
Kind
B2
Abstract

This invention relates to a natural killer cell line termed NK-92 and to NK-92 cell lines that have been modified by transfection with a vector to confer advantageous properties. The invention provides a modified NK-92 cell line that is transfected with a vector encoding a cytokine that promotes the growth of NK-92 cells. In a significant embodiment, the cytokine is interleukin 2. The invention additionally provides a modified NK-92 cell line that is transfected with a vector that expresses a thymidine kinase gene. The invention further provides a modified NK-92 cell line that is transfected with a vector that expresses a β 2 micrglobulin.

Claims (1)

1. A modified NK-92 cell, said modified NK-92 cell comprising an NK-92 cell line ATCC Deposit No. PTA-6672.

Assignments (5)
CHANGE OF NAME Recorded Aug 2, 2021
From: NANTKWEST, INC.
To: IMMUNITYBIO, INC.
Reel/Frame 057059/0802 →
CHANGE OF NAME Recorded Mar 11, 2016
From: CONKWEST, INC.
To: NANTKWEST, INC.
Reel/Frame 038071/0681 →
CHANGE OF NAME Recorded Jun 2, 2011
From: ZELLERX CORPORATION
To: CONKWEST, INC.
Reel/Frame 026382/0184 →
SECURITY AGREEMENT Recorded Oct 6, 2009
From: ZELLERX CORPORATION
To: MOSKOVITS, DAVID; SCHLESINGER, MICHAEL; ANDREW SCHLESINGER DEFINED BENEFIT PLAN; SPREI, ELI INZLICHT; SCHREIBER, MICHAEL; GOLD, JACOB DAVID; YOMTOV, MENACHEM; RIEDER, RALPH; LANG, HARVEY; LOWEY, ELIOT; BUXBAUM, GARY; WEISS, ANNIE; DAYAN, RAYMOND; EMES FOUNDATION, INC.
Reel/Frame 023332/0107 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 8, 2009
From: KLINGEMANN, HANS
To: ZELLERX CORPORATION
Reel/Frame 022790/0964 →