4-dedimethylaminotetracycline derivatives
View Patent ↗The present invention provides new chemically modified 4-dedimethylaminotetracycline compounds that can be substituted with aryl, alkenyl, or alkynyl groups. The 7, 8, and/or 9 positions and methods for preparing such compounds. Other tetracycline compounds include the 4-dedimethylaminotetracycline derivatives with an oxime group, NH-Alkyl, or N—NH-Alkyl group substituted at the C4 position as well as C2 Mannich derivatives. The present invention also provides a method of treating a mammal suffering from conditions or diseases by administering to the mammal an effective amount of the new chemically modified tetracycline compounds.
1. A 4-de(dimethylamino)doxycycline compound having structure L, M, N, or O
wherein: R7, R8, and R9 taken together in each case, have the following
meanings:
R7
R8
R9
hydrogen
hydrogen
palmitamide
(COL-803)
hydrogen
hydrogen
nitro
(COL-804)
hydrogen
hydrogen
amino
(COL-805).
2. A 4-de(dimethylamino)doxycycline compound according to claim 1 , wherein R7 is hydrogen, R8 is hydrogen and R9 is palmitamide (COL-803).
3. A 4-de(dimethylamino)doxycycline compound according to claim 1 , wherein R7 is hydrogen, R8 is hydrogen and R9 is nitro (COL-804).
4. A 4-de(dimethylamino)doxycycline compound according to claim 1 , wherein R7 is hydrogen, R8 is hydrogen and R9 is amino (COL-805).