IP Library Granted Patent US 40,279
Granted Patent E1
US 40,279 · App. 10/460,727 · Granted Apr 29, 2008

Method and system for neural tissue modification

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Quick Facts
Patent No.
US 40,279
App. No.
10/460,727
Granted
Apr 29, 2008
Kind
E1
Abstract

A method and apparatus for altering a function of neural tissue in a patient. An electromagnetic signal is applied to the neural tissue through an electrode. The electromagnetic signal has a frequency component above the physiological stimulation frequency range and an intensity sufficient to produce an alteration of the neural tissue, the alteration causing the patient to experience a reduction in pain, and a waveform that prevents lethal temperature elevation of the neural tissue during application of the electromagnetic signal to the neural tissue.

Claims (49)

1. A system for altering a function of neural tissue in a patient comprising:

a) signal applicator adapted to apply an electrical signal output to said neural tissue;

b) a signal generator that generates a electrical signal output having at least one frequency component above a physiologic stimulation frequency range, said at least one frequency component producing an alteration of a function of at least a portion of said neural tissue, and said electrical signal output having a waveform that produces an average power deposition in the neural tissue corresponding to non-lethal average temperature elevation of said at least a portion of said neural tissue when said electrical signal output is applied to said neural tissue through said signal applicator, wherein said waveform has a peak voltage, said peak voltage being sufficient to produce said alteration; and

c) a signal coupler that couples said signal generator and said signal applicator.

2. The system of claim 1 , further comprising:

a temperature sensor that senses temperature of said at least a portion of the neural tissue and produces an output signal representative of said temperature; and

a frequency component intensity control to adjust the intensity of the frequency component to maintain the temperature of the neural tissue below a lethal thermal level when said electrical signal is applied to said neural tissue.

3. The system of claim 1 , wherein said electrical output signal is a radiofrequency signal.

4. A system for altering a function of neural tissue in a patient comprising:

a) an electrode adapted to apply an amplitude modulated electrical signal to the neural tissue of the patient;

b) a signal generator that generates an amplitude modulated electrical signal having at least one frequency component above a physiological stimulation frequency range, said amplitude modulated electrical signal producing an alteration of a function of the neural tissue while producing the average power deposition in the neural tissue corresponding to non-lethal temperature elevation of said neural tissue when the amplitude modulated electrical signal is applied to the neural tissue through said electrode, wherein said amplitude modulated electrical signal has a peak voltage, said peak voltage being sufficient to produce said alteration; and

c) an electrical coupling between said signal generator and said electrode to apply said multiple modulated electrical signal to said electrode.

5. The system of claim 4 further comprising:

a modulation amplitude control that adjusts the amplitude of said amplitude modulated electrical signal.

6. The system of claim 4 wherein the amplitude modulated electric signal has a peak voltage in the range of 10 to 30 volts.

7. A method for altering the function of neural tissue in a patient comprising the steps of:

a) generating an electrical signal having at least one frequency component above a physiologic stimulation frequency range, said at least one frequency component producing an alteration of at least a portion of said neural tissue, and said electrical signal having a waveform that produces an average power deposition in the neural tissue corresponding to non-lethal average temperature elevation of said at least a portion of said neural tissue when said electrical signal is applied to said neural tissue, wherein said electrical signal has a peak voltage, said peak voltage being sufficient to produce said alteration; and

b) applying said electrical signal to said neural tissue.

8. The method of claim 7 further comprising the steps of:

a) sensing the temperature of said at least a portion of the neural tissue;

b) generating a temperature signal representative of the sensed temperature of said at least a portion of the neural tissue; and,

c) adjusting the intensity of the at least one frequency component in response to said temperature signal in order to maintain the average temperature of said at least a portion of the neural tissue below lethal temperature levels when the electrical signal is applied to said neural tissue.

9. A system for altering a function of at least a portion of neural function of tissue in a patient comprising:

a) a generator that generates an electromagnetic signal having at least one high frequency component above a physiologic stimulation frequency range, said ta least one high frequency component have a modulated waveform that produces alteration of the function of said at least a portion of said neural tissue when applied to said tissue through an electromagnetic signal applicator, wherein said modulated waveform has a peak voltage, said peak voltage being sufficient to produce said alteration.

10. A system for altering a function of neural tissue in a patient comprising:

signal applicator adapted to apply an electrical signal output to said neural tissue;

a signal generator that generates an electrical signal output having at least one frequency component above a physiologic stimulation frequency range, said at least one frequency component producing an alteration of a function of at least a portion of said neural tissue, and said electrical signal output including interrupted radiofrequency waveforms having predetermined time periods of on - time bursts of radiofrequency output of a first predetermined duration, each on - time burst being followed by an off - time output period of a second predetermined duration that produces an average power deposition in the neural tissue corresponding to non - lethal average temperature elevation of said at least a portion of said neural tissue when said electrical signal output is applied to said neural tissue through said signal applicator, wherein said interrupted radiofrequency waveforms each have a peak voltage, said peak voltage being sufficient to produce said alteration; and

a signal coupler that couples said signal generator and said signal applicator.

11. The system of claim 10 , wherein the generator and signal coupler are adapted to apply the interrupted radiofrequency waveforms to the tissue in a ratio of on- time bursts of radiofrequency output to off - time bursts of approximately two percent.

12. The system of claim 10 wherein the magnitude of the output during said off- time output periods is zero.

13. The system of claim 10 wherein the magnitude of the output during said off- time output periods in minimal.

14. The system of claim 10 , further comprising:

a temperature sensor that senses temperature of said at least a portion of the neural tissue and produces an output signal representative of said temperature; and

a frequency component intensity control to adjust the intensity of the frequency component to maintain the temperature of the neural tissue below a lethal thermal level when said electrical signal is applied to said neural tissue.

15. A method for altering the function of neural tissue in a patient comprising the steps of:

a ) generating an electrical signal having at least one frequency component above a physiologic stimulation frequency range, said electrical signal output including interrupted radiofrequency waveforms having predetermined time periods of on - time bursts of radiofrequency output of a first predetermined duration, each on - time burst being followed by an off - time output period of a second predetermined duration that produces an average power deposition in the neural tissue corresponding to non - lethal average temperature elevation of said at least a portion of said neural tissue when said electrical signal is applied to said neural tissue, wherein said interrupted radiofrequency waveforms each have a peak voltage, said peak voltage being sufficient to produce said alteration; and

b ) applying said electrical signal to said neural tissue.

16. The method of claim 15 , wherein the applying step includes applying the interrupted radiofrequency waveforms to the tissue in a ratio of on- time bursts of radiofrequency output to off - time bursts of approximately two percent.

17. The method of claim 15 wherein the magnitude of the output during said off- time output periods is zero.

18. The method of claim 15 wherein the magnitude of the output during said off- time output periods is minimal.

19. The method of claim 15 further comprising the steps of:

a ) sensing the temperature of said at least a portion of the neural tissue;

b ) generating a temperature signal representative of the sensed temperature of said at least a portion of the neural tissue; and,

c ) adjusting the intensity of the at least one frequency component in response to said temperature signal in order to maintain the average temperature of said at least a portion of the neural tissue below lethal temperature levels when the electrical signal is applied to said neural tissue.

20. A system for altering a function of neural tissue in a patient comprising:

a signal applicator adapted to apply an electrical signal output to the neural tissue;

a signal generator that generates an electrical signal output having at least one frequency component above a physiologic stimulation frequency range, said at least one frequency component producing an alteration of a function of at least a portion of the neural tissue, and said electrical signal output including interrupted radiofrequency waveforms having predetermined time periods of on - time bursts of radiofrequency output of a first predetermined duration, each on - time burst being followed by an off - time output period of a second predetermined duration that produces an average power deposition in the neural tissue corresponding to non - lethal average temperature elevation of said at least a portion of said neural tissue when said electrical signal output is applied to said neural tissue through said signal applicator, wherein said on - time burst has a peak voltage, said peak voltage being in a range that includes 10 volts to 30 volts or more; and

a signal coupler that couples said signal generator and said signal applicator.

21. The system of claim 20 , wherein a number of said on- time bursts of radiofrequency output to a number of said off - time bursts defines a ratio, said ratio being about two percent.

Assignments (5)
CHANGE OF NAME Recorded Sep 21, 2010
From: TYCO HEALTHCARE GROUP AG
To: COVIDIEN AG
Reel/Frame 025017/0663 →
MERGER Recorded Sep 21, 2010
From: COVIDIEN AG
To: TYCO HEALTHCARE GROUP AG
Reel/Frame 025017/0670 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 7, 2010
From: SLUIJTER, MENNO E.; RITTMAN, WILLIAM J., III; COSMAN, ERIC R.
To: RADIONICS, INC.
Reel/Frame 023741/0973 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 7, 2010
From: RADIONICS, INC.
To: SHERWOOD SERVICES AG
Reel/Frame 023741/0988 →
CHANGE OF NAME Recorded May 13, 2009
From: SHERWOOD SERVICES AG
To: COVIDIEN AG
Reel/Frame 022668/0932 →