IP Library › Granted Patent US 7,087,430
Granted Patent B2
US 7,087,430 · App. 10/461,803 · Granted Aug 8, 2006

Human VNO cDNA libraries

View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 7,087,430
App. No.
10/461,803
Granted
Aug 8, 2006
Kind
B2
Abstract

This invention relates to DNA libraries, in particular a human VNO cDNA library is described. Pheromone receptor cDNA once isolated is transfected into competent cells. The transfected cell lines provide a scaleable source of homogeneous material to develop efficient, automated high throughput screening assays for new vomeropherins, and thereby reduce the ongoing need for human volunteers in the preclinical phases of drug discovery. Identification and characterization of the human VNO receptor(s) will facilitate the development and commercialization of vomeropherins with improved specificity, and enhanced therapeutic efficacy in the treatment of the target diseases.

Claims (4)

1. A human vomeronasal organ (VNO) cDNA library deposited with the American Type Culture Collection (ATCC) under Accession No. PTA-1213 constructed from human female VNO tissue.

2. A human cDNA library of female VNO tissue comprising cDNAs of sequences comprising SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 4, SEQ ID NO: 5, SEQ ID NO: 6, SEQ ID NO: 16, and SEQ ID NO: 17.

3. A human cDNA library of female VNO tissue of claim 2 comprising cDNAs encoding Gα proteins G i1 , G i2 , G i3 and G olf , and lacking cDNAs encoding Gα 0 proteins.

4. A human cDNA library of female VNO tissue claim 2 comprising cDNAs encoding adenylyl cyclase types 2, 3 and 7.