Compositions comprising a combination of a free sphingoid base and ceramide and uses thereof
View Patent ↗The present invention discloses a composition for topical use comprising a free sphingoid base and a ceramide. The compositions of the invention are suitable for application to skin conditions associated with an impaired barrier function, in particular to skin conditions further associated with a deranged regulation of cell growth and differentiation, an inflammatory condition and/or an infectious state.
1. A composition for topical use comprising a combination of a free sphingoid base and a ceramide, said free sphingoid base having a general structure according to Formula 1:
wherein:
A is C(H)OH-CH 2, and
R is a straight chain or branched alkyl group having 10 to 22 carbon atoms, and said ceramide having a general structure according to Formula 2:
wherein:
A and R are defined as above, and
R′ is a straight chain or branched alkyl group having 13 to 55 carbon atoms; may
optionally contain one or more double bonds; and may
optionally be substituted with one or more hydroxyl groups.
2. The composition of claim 1 , wherein the free sphingoid base is phytosphingosine.
3. The composition of claim 1 , wherein the ceramide is a mixture of two or more different ceramides.
4. The composition of claim 1 , wherein the composition further comprises one or more additional skin lipid compounds.
5. The composition of claim 1 , wherein a ceramide is present in addition to the ceramide according to Formula 2 which is selected from the group of glycoceramides and short chains ceramides.
6. The composition of claim 1 which is a dermatological composition.
7. The composition of claim 1 which is a cosmetic composition.
8. A method of making a topical composition for the treatment of a skin condition associated with an impaired barrier function which comprises adding the composition of claim 1 with a topically suitable carrier.
9. The method of claim 8 , wherein said skin condition is further associated with a condition selected from the group consisting of a deranged regulation of cell growth and differentiation, an antiinflammatory condition or an infectious state.
10. A method for the treatment of a skin condition associated with an impaired barrier function comprising the topical application of a composition according to claim 1 .
11. The method of claim 10 , wherein said skin condition is further associated with a condition selected from the group consisting of a deranged regulation of cell growth and differentiation, an antiinflammatory condition or an infectious state.
12. The method of claim 11 which is a non-therapeutical method.
13. The composition of claim 1 , wherein
R is a straight chain or branched alkyl group having 12 to 18 carbon atoms; and
R′ is a straight chain or branched alkyl group having 15 to 50 carbon atoms which may optionally contain one or more double bonds; and may optionally be substituted with one or more hydroxyl groups.
14. The composition of claim 13 , wherein
R is a straight chain or branched alkyl group having 13 carbon atoms; and
R′ is a straight chain or branched alkyl group having 18 carbon atoms which may optionally contain one or more double bonds; and may optionally be substituted with one or more hydroxyl groups.
15. The composition of claim 14 , wherein the free sphingoid base is phytosphingosine and the ceramide is selected from the group consisting of N-stearoyl-phytosphingosine, N-oleoyl-phytosphingosine, N-alpha-hydroxystearoyl-phytosphingosine and mixtures thereof.