An ultrasonograph is provided wherein the decrease of the density of the stabilized microbubble contrast agent in a desired body target area can be inhibited, radiating ultrasonic energy required for satisfactory signal-to-noise ratio and sufficient frame rate, where an ultrasonic probe transmits an ultrasonic pulse acquired by superimposing higher harmonics including a second harmonic of the fundamental onto the fundamental wave, such as a maximum positive pressure enhanced waveform or a maximum negative pressure enhanced waveform, or an acoustic pressure rise enhanced waveform or an acoustic pressure fall enhanced waveform.
1. An ultrasonograph for obtaining an image of the inside of a living body by transmitting/receiving an ultrasonic wave to the living body into which a contrast agent is introduced comprising:
an ultrasonic probe transmitting a first ultrasonic pulse and a second ultrasonic pulse, generated by superimposing higher harmonics including at least a second harmonic of a fundamental wave;
a memory for recording a first converted signal acquired by converging the signal acquired by transmission of the first ultrasonic pulse; and
a temporal change component detector for extracting a temporal change component corresponding to an irreversible change of the contrast agent caused by radiation of the ultrasonic pulse,
wherein:
the first ultrasonic pulse is an acoustic pressure rise enhanced waveform in which a leading edge of an ultrasonic acoustic pressure waveform is sharper than a trailing edge of the ultrasonic acoustic pressure waveform,
the second ultrasonic pulse is an acoustic pressure fall enhanced waveform in which a trailing edge of an ultrasonic acoustic pressure waveform is sharper than a leading edge the ultrasonic acoustic pressure waveform,
the ultrasonic probe transmits the first ultrasonic pulse or the second ultrasonic pulse with switching an ultrasonic acoustic pressure waveform,
the temporal change component detector calculates a difference between the first converted signal recorded in the memory and a second converted signal acquired by converging the signal acquired by transmission of the second ultrasonic pulse as the temporal change component, and
the temporal change component detector adds variable weight to the first converted signal and/or the second converted signal.
2. An ultrasonograph according to claim 1 , wherein:
an ultrasonic pulse transmitted from the ultrasonic probe includes a maximum positive pressure enhanced waveform in which the peak value on the side of positive acoustic pressure of maximum amplitude is larger than the peak value on the side of negative acoustic pressure.
3. An ultrasonograph according to claim 1 , wherein: an ultrasonic pulse transmitted from the ultrasonic probe includes a maximum negative pressure enhanced waveform in which the peak value of the side of negative acoustic pressure of maximum amplitude is larger than the peak value on the side of positive acoustic pressure.
4. An ultrasonograph according to claim 1 , wherein: the contrast agent includes microbubbles; and
the mean frequency of the fundamental wave is set to the resonance frequency of the microbubble at the mean diameter of microbubbles introduced.
5. An ultrasonograph according to claim 1 , wherein:
the ultrasonic pulse has a waveform generated by superimposing a second harmonic the phase of which is shifted by .pi./2 at a point that crosses zero from the fundamental wave on the fundamental wave.
6. An ultrasonograph according to claim 1 , wherein:
the ultrasonic pulse has a waveform generated by superimposing a second harmonic the phase of which is equal to that of the fundamental wave at a point that crosses zero on the fundamental wave.
7. An ultrasonic apparatus for obtaining an image of the inside of a living body by transmitting/receiving an ultrasonic wave to the living body into which a contrast agent is introduced comprising:
an ultrasonic probe transmitting a first ultrasonic pulse and a second ultrasonic pulse, generated by superimposing higher harmonics including at least a second harmonic of fundamental wave on the fundamental wave
a memory for recording a first converted signal acquired by converging the signal acquired by transmission of the first ultrasonic pulse; and
temporal change component detector extracting a temporal change component corresponding to the irreversible change of the contrast agent caused by radiation of the ultrasonic pulse,
wherein:
an ultrasonic pulse transmitted from the ultrasonic probe includes a maximum positive pressure enhanced waveform in which the peak value on the side positive acoustic pressure of maximum amplitude is larger than the peak value on the side of negative acoustic pressure,
an ultrasonic pulse transmitted from the ultrasonic probe includes a maximum negative pressure enhanced waveform in which the peak value on the side of negative acoustic pressure of maximum amplitude is larger than the peak value on the side of positive acoustic pressure,
the ultrasonic proved transmit the first ultrasonic pulse or the second ultrasonic pulse with switching an ultrasonic acoustic pressure waveform
the temporal change component detector calculates a difference between the first converted signal recorded in the memory and a second converted signal acquired by converging the signal acquired by transmission of the second ultrasonic pulse as the temporal change component; and
the temporal change component detector adds variable weight to the first converted signal and/or the second converted signal.