6-phenylbenzonaphthyridines

1. A compound of the formula I,

in which

R1 is 1-4C-alkyl,

R2 is hydroxyl, 1-4C-alkoxy, 3-7C-cycloalkoxy, 3-7C-cycloalkylmethoxy, or 1-4C-alkoxy which is completely or predominantly substituted by fluorine,

R3 is hydroxyl, 1-4C-alkoxy, 3-7C-cycloalkoxy, 3-7C-cycloalkylmethoxy, or 1-4C-alkoxy which is completely or predominantly substituted by fluorine,

or in which

R2 and R3 together are a 1-20-alkylenedioxy group,

R4 is hydrogen, halogen, nitro, 1-4C-alkyl, trifluoromethyl or 1-4C-alkoxy,

R5 is a radical of the formula (a), (b) or (c)

in which

if R5 is a radical of the formula (b), either

R6, R7, R8 and R9 independently of one another are hydrogen, 1-7C-alkyl, 3-7C-cycloalkyl, 3-7-cycloalkylmethyl or hydroxy-2-4-C-alkyl, or

R6 is hydrogen, 1-7C-alkyl, 3-7C-cycloalkyl, 3-7-cycloalkylmethyl or hydroxy-2-4-C-alkyl,

R7 is hydrogen, 1-7C-alkyl, 3-7C-cycloalkyl, 3-7-cycloalkylmethyl or hydroxy-2-4-C-alkyl,

R8 and R9, together and including the nitrogen atom to which both are bonded, are a 1-pyrrolidinyl, 1-piperidinyl, 1-hexahydroazepinyl, 4-morpholinyl or 4-(1-4C-alkyl-)-piperazin-1-yl radical,

in which

if R5 is a radical of the formula (c), either

R10, R11, R12 and R13 independently of one another are hydrogen, 1-7C-alkyl, 3-7C-cycloalkyl, 3-7-cycloalkylmethyl or hydroxy-2-4-C-alkyl, or

R10 and R11 independently of one another are hydrogen, 1-7C-alkyl, 3-7C-cycloalkyl, 3-7-cycloalkylmethyl or hydroxy-2-4-C-alkyl, and

R12 and R13, together and including the nitrogen atom to which both are bonded, are a 1-pyrrolidinyl, 1-piperidinyl, 1-hexahydroazepinyl, 4-morpholinyl or 4-(1-4C-alkyl-)-piperazin-1-yl radical, or

R10 and R11, together and including the nitrogen atom to which both are bonded, are a 1-pyrrolidinyl, 1-piperidinyl, 1-hexahydroazepinyl, 4-morpholinyl or 4-(1-4C-alkyl-)-piperazin-1-yl radical, and

R12 and R13, together and including the nitrogen atom to which both are bonded, are a 1-pyrrolidinyl, 1-piperidinyl, 1-hexahydroazepinyl, 4-morpholinyl or 4-(1-4C-alkyl-)-piperazin-1-yl radical, or

R10 and R13 independently of one another are hydrogen or 1-4C-alkyl, and

R and R12, together and including the N—C(═)—N structure to which they are bonded, are a hexahydropyrimidin-2-ylidene or imidizolidin-2-ylidene radical,

or a salt, solvate, hydrate, solvate of a salt, hydrate of a salt, N-oxide, enantiomer, E/Z isomer or tautomer thereof,

or a salt of an N-oxide, enantiomer, E/Z isomer or tautomer thereof.

2. A compound of the formula I as claimed in claim 1 ,in which

R1 is 1-4C-alkyl,

R2 is hydroxyl, 1-4C-alkoxy, 3-7C-cycloalkoxy, 3-7C-cycloalkylmethoxy, or 1-4C-alkoxy which is completely or predominantly substituted by fluorine,

R3 is hydroxyl, 1-4C-alkoxy, 3-7C-cycloalkoxy, 3-7C-cycloalkylmethoxy, or 1-4C-alkoxy which is completely or predominantly substituted by fluorine,

or in which

R2 and R3 together are a 1-2C-alkylenedioxy group,

R4 is hydrogen, halogen, nitro, 1-4C-alkyl, trifluoromethyl or 1-4C-alkoxy,

R5 is a radical of the formula (a), (b) or (c)

in which

if R5 is a radical of the formula (b), either

R6, R7, R8 and R9 independently of one another are hydrogen, 1-7C-alkyl, 3-7C-cycloalkyl, 3-7-cycloalkylmethyl or hydroxy-2-4-C-alkyl, or

R6 is hydrogen, 1 -7C-alkyl, 3-7C-cycloalkyl, 3-7-cycloalkylmethyl or hydroxy-2-4-C-alkyl,

R7 is hydrogen, 1-7C-alkyl, 3-7C-cycloalkyl, 3-7-cycloalkylmethyl or hydroxy-2-4-C-alkyl,

R8 and R9, together and including the nitrogen atom to which both are bonded, are a 1-pyrrolidinyl, 1-piperidinyl, 1-hexahydroazepinyl, 4-morpholinyl or 4-(1-4C-alkyl-)-piperazin-1-yl radical,

in which

if R5 is a radical of the formula (c), either

R10, R11, R12 and R13 independently of one another are hydrogen, 1-7C-alkyl, 3-7C-cycloalkyl, 3-7-cycloalkylmethyl or hydroxy-2-4-C-alkyl, or

R10 and R11 independently of one another are hydrogen, 1-7C-alkyl, 3-7C-cycloalkyl, 3-7-cycloalkylmethyl or hydroxy-2-4-C-alkyl, and

R12 and R13, together and including the nitrogen atom to which both are bonded, are a 1-pyrrolidinyl, 1-piperidinyl, 1-hexahydroazepinyl, 4-morpholinyl or 4-(1-4C-alkyl-)-piperazin-1-yl radical, or

R10 and R11, together and including the nitrogen atom to which both are bonded, are a 1-pyrrolidinyl, 1-piperidinyl, 1-hexahydroazepinyl, 4-morpholinyl or 4-(1-4C-alkyl-)-piperazin-1-yl radical, and

R12 and R13, together and including the nitrogen atom to which both are bonded, are a 1-pyrrolidinyl, 1-piperidinyl, 1-hexahydroazepinyl, 4-morpholinyl or 4-(1-4C-alkyl-)-piperazin-1-yl radical, or

R10 and R13 independently of one another are hydrogen or 1-4C-alkyl, and

R11 and R12, together and including the N—C(═)—N structure to which they are bonded, are a hexahydropyrimidin-2-ylidene or imidizolidin-2-ylidene radical,

or a salt, solvate, hydrate, solvate of a salt, hydrate of a salt, enantiomer, E/Z isomer or tautomer thereof,

or a salt of an enantiomer, E/Z isomer or tautomer thereof.

3. A compound of the formula I as claimed in claim 1 , in which

R1 is 1-4C-alkyl,

R2 is 1-4C-alkoxy, 3-6C-cycloalkoxy, 3-6C-cycloalkylmethoxy, or 1-4C-alkoxy which is completely or predominantly substituted by fluorine,

R3 is 1-4C-alkoxy, 3-6C-cycloalkoxy, 3-6C-cycloalkylmethoxy, or 1-4C-alkoxy which is completely or predominantly substituted by fluorine,

R4 is hydrogen, halogen, nitro, 1-4C-alkyl, trifluoromethyl or 1-4C-alkoxy,

R5 is a radical of the formula (a), (b) or (c)

in which

if R5 is a radical of the formula (b), either

R6 is hydrogen, and

R7, R8 and R9 independently of one another are hydrogen, 1-4C-alkyl, 3-7C-cycloalkyl, 3-7-cycloalkylmethyl or hydroxy-2-4-C-alkyl, or

R6 is hydrogen,

R7 is hydrogen, 1-4C-alkyl, 3-7C-cycloalkyl or 3-7C-cycloalkylmethyl, and

R8 and R9, together and including the nitrogen atom to which both are bonded, are a 1-pyrrolidinyl, 1-piperidinyl, 1-hexahydroazepinyl, 4-morpholinyl or 4-(1-2C-alkyl)-piperazin-1-yl radical,

in which

if R5 is a radical of the formula (c), either

R10, R11, R12 and R13 independently of one another are hydrogen, 1-4C-alkyl, 3-7C-cycloalkyl, 3-7-cycloalkylmethyl or hydroxy-2-4-C-alkyl, or

R10 and R11 independently of one another are hydrogen, 1-4C-alkyl, 3-7C-cycloalkyl, 3-7-cycloalkylmethyl or hydroxy-2-4-C-alkyl, and

R12 and R13, together and including the nitrogen atom to which both are bonded, are a 1-pyrrolidinyl, 1-piperidinyl, 1-hexahydroazepinyl, 4-morpholinyl or 4-(1-2C-alkyl)-piperazin-1-yl radical, or

R10 and R11, together and including the nitrogen atom to which both are bonded, are a 1-pyrrolidinyl, 1-piperidinyl, 1-hexahydroazepinyl, 4-morpholinyl or 4-(1-2C-alkyl)-piperazin-1-yl radical, and

R12 and R13, together and including the nitrogen atom to which both are bonded, are a 1-pyrrolidinyl, 1-piperidinyl, 1-hexahydroazepinyl, 4-morpholinyl or 4-(1-2C-alkyl)-piperazin-1-yl radical, or

R10 and R13 independently of one another are hydrogen or 1-4C-alkyl, and

R11 and R12, together and including the N—C(═)—N structure to which they are bonded, are a hexahydropyrimidin-2-ylidene or imidizolidin-2-ylidene radical,

or a salt, solvate, hydrate, solvate of a salt, hydrate of a salt, N-oxide, enantiomer, E/Z isomer or tautomer thereof,

or a salt of an N-oxide, enantiomer, E/Z isomer or tautomer thereof.

4. A compound of the formula I as claimed in claim 1 , in which

R1 is 1-4C-alkyl,

R2 is 1-4C-alkoxy, 3-6C-cycloalkoxy, 3-6C-cycloalkylmethoxy, or 1-4C-alkoxy which is substituted by fluorine,

R3 is 1-4C-alkoxy, 3-6C-cycloalkoxy, 3-6C-cycloalkylmethoxy, or 1-40-alkoxy which is substituted by fluorine,

R4 is hydrogen, halogen, nitro, 1-4C-alkyl, trifluoromethyl or 1-4C-alkoxy,

R5 is a radical of the formula (a), (b) or (c)

in which

if R5 is a radical of the formula (b), either

R6 is hydrogen, and

R7, R8 and R9 independently of one another are hydrogen, 1-4C-alkyl, 3-7C-cycloalkyl, 3-7-cycloalkylmethyl or hydroxy-2-4-C-alkyl, or

R6 is hydrogen,

R7 is hydrogen, 1-4C-alkyl, 3-7C-cycloalkyl or 3-7C-cycloalkylmethyl, and

R8 and R9, together and including the nitrogen atom to which both are bonded, are a 1-pyrrolidinyl, 1-piperidinyl, 1-hexahydroazepinyl, 4-morpholinyl or 4-(1-2C-alkyl)-piperazin-1-yl radical,

in which

if R5 is a radical of the formula (c), either

R10, R11, R12 and R13 independently of one another are hydrogen, 1-4C-alkyl, 3-7C-cycloalkyl, 3-7-cycloalkylmethyl or hydroxy-2-4C-alkyl, or

R10 and R11 independently of one another are hydrogen, 1-4C-alkyl, 3-7C-cycloalkyl, 3-7-cycloalkylmethyl or hydroxy-2-4-C-alkyl, and

R12 and R13, together and including the nitrogen atom to which both are bonded, are a 1-pyrrolidinyl, 1-piperidinyl, 1-hexahydroazepinyl, 4-morpholinyl or 4-(1-2C-alkyl)-piperazin-1-yl radical, or

R10 and R11, together and including the nitrogen atom to which both are bonded, are a 1-pyrrolidinyl, 1-piperidinyl, 1-hexahydroazepinyl, 4-morpholinyl or 4-(1-2C-alkyl)-piperazin-1-yl radical, and

R12 and R13, together and including the nitrogen atom to which both are bonded, are a 1-pyrrolidinyl, 1-piperidinyl, 1-hexahydroazepinyl, 4-morpholinyl or 4-(1-2C-alkyl)-piperazin-1-yl radical, or

R10 and R13 independently of one another are hydrogen or 1-4C-alkyl, and

R11 and R12, together and including the N—C(═)—N structure to which they are bonded, are a hexahydropyrimidin-2-ylidene or imidizolidin-2-ylidene radical,

or a salt, solvate, hydrate, solvate of a salt, hydrate of salt, enantiomer, E/Z isomer or tautomer thereof,

or a salt of an enantiomer, E/Z isomer or tautomer thereof.

5. A compound of the formula I as claimed in claim 1 , in which

R1 is methyl,

R2 is 1-4C-alkoxy,

R3 is 1-4C-alkoxy,

R4 is hydrogen,

R5 is a radical of the formula (a), (b) or (c)

in which

if R5 is a radical of the formula (b), either

R6 is hydrogen,

R7 is hydrogen, 1-4C-alkyl, 3-7C-cycloalkyl or 3-7-cycloalkylmethyl,

R8 is hydrogen, 1-4C-alkyl, 3-7C-cycloalkyl or 3-7-cycloalkylmethyl,

R9 is hydrogen, 1-4C-alkyl or hydroxy-2-4-C-alkyl,

where atleast one of the radicals R7, R8 and R9 is not hydrogen, or

R6 is hydrogen,

R7 is hydrogen, 1-4C-alkyl, 3-7C-cycloalkyl or 3-7C-cycloalkylmethyl, and

R8 and R9, together and including the nitrogen atom to which both are bonded, are a 1-pyrrolidinyl, 1-piperidinyl, 1-hexahydroazepinyl, 4-morpholinyl or 4-(1-2C-alkyl)-piperazin-1-yl radical,

in which

if R5 is a radical of the formula (c), either

R10 is hydrogen or 10-4C-alkyl,

R11 is hydrogen, 1-4C-alkyl, 3-7C-cycloalkyl, 3-7-cycloalkylmethyl,

R12 is hydrogen, 1-4-C-alkyl, 3-7C-cycloalkyl, 3-7-cycloalkylmethyl, and

R13 is hydrogen, 1-4C-alkyl or hydroxy-2-4-C-alkyl,

where atleast one of the radicals R10, R11, R12 and R13 is not hydrogen, or

R10 is hydrogen or 1-4C-alkyl,

R11 is hydrogen, 1-4C-alkyl, 3-7C-cycloalkyl or 3-7-cycloalkylmethyl, and

R12 and R13, together and including the nitrogen atom to which both are bonded, are a 1-pyrrolidinyl, 1-piperidinyl, 1-hexahydroazepinyl, 4-morpholinyl or 4-(1-2C-alkyl)-piperazin-1-yl radical, or

R10 and R11, together and including the nitrogen atom to which both are bonded, are a 1-pyrrolidinyl, 1-piperidinyl, 1-hexahydroazepinyl, 4-morpholinyl or 4-(1-2C-alkyl)-piperazin-1-yl radical, and

R12 and R13, together and including the nitrogen atom to which both are bonded, are a 1-pyrrolidinyl, 1-piperidinyl, 1-hexahydroazepinyl, 4-morpholinyl or 4-(1-2C-alkyl)-piperazin-1-yl radical,

or a salt, solvate, hydrate, solvate of a salt, hydrate of a salt, N-oxide, enantiomer, E/Z isomer or tautomer thereof,

or a salt of an N-oxide, enantiomer, E/Z isomer or tautomer thereof.

6. A compound of the formula I as claimed in claim 1 , in which

R1 is methyl,

R2 is methoxy or ethoxy,

R3 is methoxy,

R4 is hydrogen,

R5 is N′-(N,N-dimethyl)guanidinyl, N′-(N,N-diethyl) guanidinyl, (morpholine)-4-carboxamidinyl, 4-methylpiperazine-1-carboxamidinyl-, N′-[N-(2-hydroxyethyl)-N-methyl]guanidinyl, N″-(N,N,N′,N′-tetramethyl)guanidinyl, N-guanidinyl, N′-(N,N,N″-trimethyl)guanidinyl, N-(N′-methyl)guanidinyl, N-(N′-isopropyl)guanidinyl, N-(N′-propyl)guanidinyl, N-(N′-isobutyl)guanidinyl, N-(N′-ethyl) guanidinyl, N-cyclohexyl-N′-guanidinyl, N-cyclohexylmethyl-N′-guanidinyl, N-butyl-N′-guanidinyl or pyrrolidin-1-carboxamidinyl,

or a salt, solvate, hydrate, solvate of a salt, hydrate of a salt, N-oxide, enantiomer, E/Z isomer or tautomer thereof,

or a salt of an N-oxide, enantiomer, E/Z isomer or tautomer thereof.

7. A compound, of the formula I as claimed in claim 1 , in which

R1 is methyl,

R2 is 1-4C-alkoxy,

R3 is 1-4C-alkoxy,

R4 is hydrogen,

R5 is a radical of the formula (b) or (c)

in which

if R5 is a radical of the formula (b), either

R6 is hydrogen,

R7 is hydrogen, 1-4C-alkyl, 3-7C-cycloalkyl or 3-7C-cycloalkylmethyl,

R8 is hydrogen, 1-4C-alkyl, 3-7C-cycloalkyl or 3-7C-cycloalkylmethyl, and

R9 is hydrogen, 1-4C-alkyl or hydroxyl-2-4C-alkyl,

where atleast one of the radicals R7, R8 and R9 is not hydrogen, or

R6 is hydrogen,

R7 is hydrogen, 1-4C-alkyl, 3-7C-cycloalkyl or 3-7C-cycloalkylmethyl, and

R8 and R9, together and including the nitrogen atom to which both are bonded, are a 1-pyrrolidinyl, 1-piperidinyl, 1-hexahydroazepinyl, 4-morpholinyl or 4-(1-2C-alkyl)-piperazin-1-yl radical,

in which

if R5 is a radical of the formula (c), either

R10 is hydrogen or 1-4C-alkyl,

R11 is hydrogen, 1-4C-alkyl, 3-7C-cycloalkyl, 3-7-cycloalkylmethyl,

R12 is hydrogen, 1-4C-alkyl, 3-7C-cycloalkyl, 3-7-cycloalkylmethyl, and

R13 is hydrogen, 1-4C-alkyl or hydroxy-2-4-C-alkyl,

where at least one of the radicals R10, R11, R12 and R13 is not hydrogen, or

R10 is hydrogen or 1-4C-alkyl,

R11 is hydrogen, 1-4C-alkyl, 3-7C-cycloalkyl or 3-7-cycloalkylmethyl, and

R12 and R13, together and including the nitrogen atom to which both are bonded, are a 1-pyrrolidinyl, 1-piperidinyl, 1-hexahydroazepinyl, 4-morpholinyl or 4-(1-2C-alkyl)-piperazin-1-yl radical, or

R10 and R11, together and including the nitrogen atom to which both are bonded, are a 1-pyrrolidinyl, 1-piperidinyl, 1-hexahydroazepinyl, 4-morpholinyl or 4-(1-2C-alkyl)-piperazin-1-yl radical, and

R12 and R13, together and including the nitrogen atom to which both are bonded, are a 1-pyrrolidinyl, 1-piperidinyl, 1-hexahydroazepinyl, 4-morpholinyl or 4-(1-2C-alkyl)-piperazin-1-yl radical,

or a salt, solvate, hydrate, solvate of a salt, hydrate of a salt, enantiomer, E/Z isomer or tautomer thereof,

or a salt of an enantiomer, E/Z isomer or tautomer thereof.

8. A compound of the formula I as claimed in claim 1 , in which

R1 is methyl,

R2 is methoxy, ethoxy or propoxy,

R3 is methoxy or ethoxy,

R4 is hydrogen,

R5 is N′-(N,N-dimethyl)guanidinyl, N′(N,N-diethyl)guanidinyl, (morpholine)-4-carboxamidinyl, 4-methylpiperazine-1-carboxamidinyl, N′-[N-(2-hydroxyethyl)-N-methyl]guanidinyl, N″-(N,N,N′,N′-tetramethyl)guanidinyl,

or a salt, solvate, hydrate, solvate of a salt, hydrate of a salt, enantiomer, E/Z isomer or tautomer thereof,

or a salt of an enantiomer, E/Z isomer or tautomer thereof.

9. A compound of the formula I, selected from the group consisting of

4-[(+)-cis-9-Ethoxy-8-methoxy-2-methyl-1,2,3,4,4a,10b-hexahydro[c][1,6]naphthyridin-6-yl)-N-(1-imino-1-morpholin-4-ylmethyl) ]benzamide,

N′-{1-[4-((+)-cis-9-Ethoxy-8-methoxy-2-methyl-1,2,3,4,4a,10b-hexahydro[c][1,6]naphthyridin-6-yl)-phenyl[methanoyl}-N, N-diethylguanidine,

N′-{1-[4-((+)-cis-9-Ethoxy-8-methoxy-2-methyl-1,2, 3,4,4a,10b-hexahydro[c][1,6]naphthyridin-6-yl)phenyl[methanoyl}-N,N-dimethylguanidine,

N′-{1-[4-((+)-cis-9-Ethoxy-8-methoxy-2-methyl-1,2,3,4,4a,10b-hexahydro[c][1,6]naphthyridin-6-yl)-phenyl[methanoyl}-N-(2-hydroxyethyl)-N-methylguanidine,

N″-(1-[4-((−)-cis-9-Ethoxy-8-methoxy-2-methyl-1,2,3,4,4a,10b-hexahydro[c][1,6]naphthyridin-6-yl)-phenyl]methanoyl}-N,N,N′,N′-tetramethylguanidine,

N-[1-Amino-1-(4-methylpiperazin-1-yl)methylene]-4-((+)-cis-9-ethoxy-8-methoxy-2methyl-1,2,3,4, 4a,10b-hexahydro[c][1,6]naphthyridin-6-yl)benzamide,

N-{1-[4-((−)cis-9-Ethoxy-8-methoxy-2-methyl-1,2,3,4,4a,10b-hexahydro-benzo[c][1,6]naphthyridin-6-yl)phenyl]-methanoyl}-guanidine,

N′-(1-[4-((−)-cis-8,9-Dimethoxy-2-methyl-1,2,3,4,4a,10b-hexahydro-benzo[c][1,6]naphthyridin-6-yl)phenyl]-methanoyl}-N,N-dimethyl-guanidine,

N″-{1-[4-((−)-cis-8,9-Dimethoxy-2-methyl-1,2,3,4,4a,10b-hexahydro-benzo[c][1,6]naphthyridin-6-yl)phenyl]-methanoyl}-N,N,N′,N′-tetramethyl-guanidine,

N′-(1-[3-(cis)-9-Ethoxy-8-methoxy-2-methyl-1,2, 3,4,4a,10b-hexahydro-benzo[c][1,6]naphthyridin-6-yl)phenyl]-methanoyl}-N,N-dimethyl-guanidine,

4-((cis)-9-Ethoxy-8-methoxy-2-methyl-1,2,3,4,4a,10b-hexahydro-benzo[c][1,6]naphthyridin-6-yl)-N-(11-imino-1-pyrrolidin-1-yl-methyl)-benzamide,

N-(1[-4-(cis)-8,9-Dimethoxy-2-methyl-1,2,3,4,4a,10b-hexahydro-benzo[c][1,6]naphthyridin-6-yl)phenyl]-methanoyl}-guanidine,

N′-(1-[4-((cis)-9-Ethoxy-8-methoxy-2-methyl-1,2,3,4,4a,10b-hexahydro-benzo[c][1,6]naphthyridin-6-yl)phenyl]-methanoyl}-N,N,N″-trimethyl-guanidine,

N-{1-[4-((−)-cis-9-Ethoxy-8-methoxy-2-methyl-1,2,3,4,4a,10b-hexahydro-benzo[c][1,6]naphthyridin-6-yl)phenyl]-methanoyl}-N′-methyl-guanidine,

N-{1-[4-((−)-cis-9-Ethoxy-8-methoxy-2-methyl-1,2,3,4,4a,10b-hexahydro-benzo[c][1,6]naphthyridin-6-yl)-phenyl]-methanoyl}-N′-isopropyl-guanidine,

N-{1-[4-((−)-cis-9-Ethoxy-8-methoxy-2-methyl-1,2,3,4,4a,10b-hexahydro-benzo[c][1,6]naphthyridin-6-yl)phenyl]-methanoyl}-N′-propyl-guanidine,

N-{1-[4-((−)-cis-9-Ethoxy-8-methoxy-2-methyl-1,2,3,4,4a,10b-hexahydro-benzo[c][1,6]naphthyridin-6-yl)-phenyl]-methanoyl}-N′-isobutyl-guanidine,

N-{1-[4-((−)-cis-9-Ethoxy-8-methoxy-2-methyl-1,2,3,4,4a,10b-hexahydro-benzo[c][1,6]naphthyridin-6-yl)-phenyl]-methanoyl}-N′-ethyl-guanidine,

N-Cyclohexyl-N′-{1-[4-((−)-cis-9-ethoxy-8-methoxy-2-methyl-1,2,3,4,4a,10b-hexahydro-benzo[c][1,6]naphthyridin-6-yl)-phenyl]-methanoyl}-guanidine,

N-Cyclohexylmethyl-N′-{1-[4-((−)-cis-9-ethoxy-8-methoxy-2-methyl-1,2,3,4,4a,10b-hexahydro-benzo[c][1,6]naphthyridin-6-yl)-phenyl]-methanoyl}-guanidine,

N-Butyl-N′-{1-[4-((−)-cis-9-ethoxy-8-methoxy-2-methyl-1,2,3,4,4a,10b-hexahydro-benzo[c][1,6]naphthyridin-6-yl)-phenyl]-methanoyl}-guanidine,

N′-{1-[4-((−)-cis-9-Ethoxy-8-methoxy-2-methyl1-2-oxy-2,3,4,4a,10b-hexahydro-benzo[c][1,6]naphthyridin-6-yl)-phenyl]-methanoyl}-N,N-dimethyl-guanidine,

or a salt, solvate, hydrate, solvate of a salt or hydrate of a salt thereof.

10. A compound of the formula I as claimed in claim 1 , in which the hydrogen atoms in positions 4a and 10b are in the cis position relative to one another,

or a salt, solvate, hydrate, solvate of a salt, hydrate of a salt, N-oxide, enantiomer, E/Z isomer or tautomer thereof,

or a salt of an N-oxide, enantiomer, E/Z isomer or tautomer thereof.

11. A compound of the formula I as claimed in claim 2 , in which the hydrogen atoms in positions 4a and 10b are in the cis position relative to one another,

or a salt, solvate, hydrate, solvate of a salt, hydrate of a salt, enantiomer, E/Z isomer or tautomer thereof,

or a salt of an a enantiomer, E/Z isomer or tautomer thereof.

12. A compound of the formula I as claimed in claim 1 which, in positions 4a and 10b, has the same absolute configuration as the compound (−)-cis-4-amino-3-(3-ethoxy-4-methoxyphenyl)-1-methyl-piperidine dihydrochloride having the optical rotation [α] 20 =−65.5° (c=1, methanol),

or a salt, solvate, hydrate, solvate of a salt, hydrate of a salt, N-oxide, enantiomer, E/Z isomer or tautomer thereof,

or a salt of an N-oxide, enantiomer, E/Z isomer or tautomer thereof.

13. A compound of the formula I as claimed in claim 2 which, in positions 4a and 10b, has the same absolute configuration as the compound (−)-cis-4-amino-3-(3-ethoxy-4-methoxyphenyl)-1-methyl-piperidine dihydrochloride having the optical rotation [α] 20 =−65.5° (c=1, methanol),

or a salt, solvate, hydrate, solvate of a salt, hydrate of a salt, enantiomer, E/Z isomer or tautomer thereof,

or a salt of an enantiomer, E/Z isomer or tautomer thereof.

14. A method of treating a disease or disorder in a patient comprising administering to a patient in need thereof a thereapeutically effective amount of a compound of the formula I as claimed in claim 1 or a pharmaceutically acceptable salt, solvate, hydrate, solvate of a salt, hydrate of a salt, N-oxide, enantiomer, E/Z isomer or tautomer thereof,

or a pharmaceutically acceptable salt of an N-oxide, enantiomer, E/Z isomer or tautomer thereof wherein the disease or disorder is selected from the group consisting of allergic rhinitis, crohn's disease, ulcerative colitis, rheumatoid arthritis, bronchitis, bronchial asthma, COPD, ARDS, psoriasis, eczema, and combination thereof thereof.

15. A pharmaceutical composition comprising one or more compounds of the formula I as claimed in claim 1 or a pharmaceutically acceptable salt, solvate, hydrate, solvate of a salt, hydrate of a salt, N-oxide, enantiomer, E/Z isomer or tautomer thereof,

or a pharmaceutically acceptable salt of an N-oxide, enantiomer, E/Z isomer or tautomer thereof, together with a pharmaceutically acceptable auxiliary and/or excipient.

16. A method of treating a disease or disorder in a patient comprising administering to a patient in need thereof a thereapeutically effective amount of a compound of the formula I as claimed in claim 1 or a pharmaceutically acceptable salt, solvate, hydrate, solvate of a salt, hydrate of a salt, N-oxide, enantiomer, E/Z isomer or tautomer thereof,

or a pharmaceutically acceptable salt of an N-oxide, enantiomer, E/Z isomer or tautomer thereof,

wherein the disease or disorder is selected from the group consisting of bronchitis, bronchial asthma, COPD, ARDS, psoriasis, eczema, and combinations thereof.