Aminoderivatives of biotin and their conjugates with macrocyclic chelating agents

1. A compound of Formula (I):

where:

Q is a —(CH 2 ) n — group, where n is an integer from 4 to 12, in which case R′ does not exist, or Q is selected from the group consisting of —(CH 2 ) a —CH(R′)—(CH 2 ) b —, where a and b are, independently, 0 or h, wherein h is an integer from 4 to 12, R′ is as defined here below, or Q is cyclohexyl, phenyl, in which case R′ is a substituent on the cyclohexyl or phenyl ring;

R is hydrogen or -Λ, where -Λ is a formula (II) macrocycle:

where the various Ys, which may be the same or different, are selected from the group consisting of hydrogen, a C 2 alkyl group, straight or branched C 3 -C 4 alkyl, —(CH 2 ) m —COOH, where m is an integer from 1 to 3;

X is hydrogen, or the —CH 2 —U group, where U is selected from methyl, ethyl, p-aminophenyl, or X is the —(CHW) o —Z group, where o is an integer from 1 to 5, W is hydrogen, methyl or ethyl, Z is a heterocyclic group with 5 or 6 members containing one or more heteroatoms selected from O, N—R 1 , R 1 being a hydrogen, C 1 -C 2 alkyl group, or a straight or branched C 3 -C 4 alkyl group, and S; or Z is selected from —NH 2 , —NH—C(=NH)—NH 2 , or —S—R 2 where R 2 is a C 1 or C 2 alkyl group or a straight or branched C 3 -C 4 alkyl group;

p is the integer 2 or 3

R′ is selected from the group consisting of hydrogen, a C 1 -C 2 alkyl group, a straight or branched C 3 -C 4 alkyl, —(CH 2 ) q —T, where T is selected from the group consisting of S—CH 3 , —OH, or —COOH, and q is the integer 1 or 2;

R″ has the same meanings as R, with the following conditions:

if R is -Λ, R″ is hydrogen; if R is hydrogen, R″ is -Λ, or R and R″ are (CH 2 ) r -Λ (for R), where r is an integer from 4 to 12, and -Λ (for R″), respectively, Q being a —(CH 2 ) n — group where n is an integer from 4 to 12.

2. A composition containing a compound according to claim 1 , in a mixture with a suitable vehicle and/or excipient.