IP Library Granted Patent US 7,608,276
Granted Patent B2
US 7,608,276 · App. 10/471,571 · Granted Oct 27, 2009

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Quick Facts
Patent No.
US 7,608,276
App. No.
10/471,571
Granted
Oct 27, 2009
Kind
B2
Abstract

The invention provides proteins from Staphylococcus aureus including amino acid sequences and the corresponding nucleotide sequences. The proteins are useful for vaccines, immunogenic compositions, diagnostics, enzymatic studies and also as targets for antibiotics.

Claims (30)

1. An isolated protein comprising the amino acid sequence of SEQ ID NO:1168.

2. An isolated hybrid protein represented by the formula NH 2 —A—[—X—L—] n —B—COOH, wherein X is the amino acid sequence of SEQ ID NO: 1168, L is an optional linker amino acid sequence, A is an optional N-terminal amino acid sequence, B is an optional C-terminal amino acid sequence, and n is an integer greater than 1.

3. A composition comprising the isolated protein of claim 1 .

4. A composition according to claim 3 being a immunogenic composition or a diagnostic composition.

5. A composition according to claim 3 or claim 4 further comprising a pharmaceutically acceptable carrier.

6. The composition of claim 3 further comprising one or more of the following antigens:

a protein antigen from Helicobacter pylori;

a protein antigen from N.meningitidis serogroup B;

an outer-membrane vesicle (OMV) preparation from N meningitidis;

a saccharide antigen from N.meningitidis serogroup A, C, W135 and/or Y;

a saccharide antigen from Streptococcus pneumoniae;

an antigen from hepatitis A virus;

an antigen from hepatitis B virus;

an antigen from hepatitis C virus;

an antigen from Bordetella pertussis;

a diphtheria antigen;

a tetanus antigen;

a saccharide antigen from Haemophilus influenzae B.;

an antigen from N gonorrhoeae;

an antigen from Chlamydia pneumoniae;

an antigen from Streptococcus agalactiae;

an antigen from Streptococcus pyogenes;

an antigen from Chlamydia trachomatis;

an antigen from Porphyromonas gingivalis;

polio antigen(s);

rabies antigen(s);

measles, mumps and/or rubella antigens;

influenza antigen(s); or

an antigen from Moraxella catarrhalis.

7. A composition according to claim 3 , further comprising one or more isolated proteins comprising an amino acid sequence selected from the group consisting of SEQ ID NO: 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, 36, 38, 40, 42, 44, 46, 48, 50, 52, 54, 56, 58, 60, 62, 64, 66, 68, 70, 72, 74, 76, 78, 80, 82, 84, 86, 88, 90, 92, 94, 96, 98, 100, 102, 104, 106, 108, 110, 112, 114, 116, 118, 120, 122, 124, 126, 128, 130, 132, 134, 136, 138, 140, 142, 144, 146, 148, 150, 152, 154, 156, 158, 160, 162, 164, 166, 168, 170, 172, 174, 176, 178, 180, 182, 184, 186, 188, 190, 192, 194, 196, 198, 200, 202, 204, 206, 208, 210, 212, 214, 216, 218, 220, 222, 224, 226, 228, 230, 232, 234, 236, 238, 240, 242, 244, 246, 248, 250, 252, 254, 256, 258, 260, 262, 264, 266, 268, 270, 272, 274, 276, 278, 280, 282, 284, 286, 288, 290, 292, 294, 296, 298, 300, 302, 304, 306, 308, 310, 312, 314, 316, 318, 320, 322, 324, 326, 328, 330, 332, 334, 336, 338, 340, 342, 344, 346, 348, 350, 352, 354, 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5116, 5118, 5120, 5122, 5124, 5126, 5128, 5130, 5132, 5134, 5136, 5138, 5140, 5142, 5144, 5146, 5148, 5150, 5152, 5154, 5156, 5158, 5160, 5162, 5164, 5166, 5168, 5170, 5172, 5174, 5176, 5178, 5180, 5182, 5184, 5186, 5188, 5190, 5192, 5194, 5196, 5198, 5200, 5202, 5204, 5206, 5208, 5210, 5212, 5214, 5216, 5218, 5220, 5222, 5224, 5226, 5228, 5230, 5232, 5234, 5236, 5238, 5240, 5242, 5244, 5246, 5248, 5250, 5252, 5254, 5256, 5258, 5260, 5262, 5264, 5266, 5268, 5270, 5272, 5274, 5276, 5278, 5280, 5282, 5284, 5286, 5288, 5290, 5292, 5294, 5296, 5298, 5300, 5302, 5304, 5306, 5308, 5310, 5312, 5314, 5316, 5318, 5320, 5322, 5324, 5326, 5328, 5330, 5332, 5334, 5336, 5338, 5340, 5342, 5344, 5346, 5348, 5350, 5352, 5354, 5356, 5358, 5360, 5362, 5364, 5366, 5368, 5370, 5372, 5374, 5376, 5378, 5380, 5382, 5384, 5386, 5388, 5390, 5392, 5394, 5396, 5398, 5400, 5402, 5404, 5406, 5408, 5410, 5412, 5414, 5416, 5418, 5420, 5422, 5424, 5426, 5428, 5430, 5432, 5434, 5436, 5438, 5440, 5442, 5444, 5446, 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Assignments (3)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 20, 2016
From: NOVARTIS VACCINES AND DIAGNOSTICS SRL
To: GLAXOSMITHKLINE BIOLOGICALS SA
Reel/Frame 040077/0901 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 1, 2008
From: NOVARTIS VACCINES AND DIAGNOSTICS SRL
To: NOVARTIS AG
Reel/Frame 021904/0964 →
CHANGE OF NAME Recorded Apr 16, 2008
From: CHIRON, S.R.L.
To: NOVARTIS VACCINES AND DIAGNOSTICS S.R.L.
Reel/Frame 020822/0574 →