MCH1R deficient mice
View Patent ↗The present invention features viable MCH1R deficient mice. MCH1R deficient mice contain an alteration in one or both MCH1R alleles that substantially reduces expression of a functional MCH1R from the altered allele. Preferably, MCH1R deficient mice are MCH1R −/− knockout mice.
1. A transgenic mouse whose genome comprises a homozygous disruption in it's melanin concentrating hormone type 1 receptor (MCH1R) gene, wherein said disruption results in one or more phenotypes selected from the group consisting of: hyperphagia, reduced fat mass, increased lean mass, increased ambulatory activity and increased fine movements.
2. The transgenic mouse of claim 1 , wherein said mouse comprises each of said phenotypes.
3. A method of measuring the affect of a compound on MCH1R deficiency comprising the steps of providing said compound to the mouse of claim 1 , and measuring the affect of said compound on one or more phenotypes associated with MCH1R deficiency.
4. The method of claim 3 , wherein said method comprises measuring hyperphagic or hypophagic activity.
5. The method of claim 3 , wherein said method comprises measuring a change in fat mass.
6. The method of claim 3 , wherein said method comprises measuring a change in muscle mass.
7. The method of claim 3 , wherein said method comprises measuring increased or decreased locomotor activity.
8. The method of claim 3 , wherein said method comprises measuring increased or decreased fine motor movements.
9. The method of claim 3 , wherein said phenotype is an increased or decreased metabolic indicator selected from the group consisting of: oxygen consumption, carbon dioxide production, metabolic rate, pseudo-resting metabolic rate, respiratory exchange ratio and respiratory quotient.
10. The method of claim 3 , wherein said compound is active at MCH2R.