Preparation for the prophylaxis of restenosis
The invention relates to a preparation for restenosis prevention. The preparations for restenosis prevention known as yet do not reach sufficient active agent concentrations in the affected sections of the vascular walls as higher doses cause undesirable side effects. The present invention is a preparation to which at least one antihyperplastic agent is added that has a distribution ratio between butanol and water ≧0.5. The lipophilic active agent is absorbed by the vascular wall fast and in sufficient quantity. The preparation may be a liquid that can pass through capillaries and may contain a contrast agent so that the active agent is transferred into the vascular wall without any additional effort while the usually required contrast radiograms are taken. The preparation may also be applied to a catheter.
1. An angiography catheter comprising a coating comprising a dried preparation comprising a mixture of (a) paclitaxel and (b) iopromide, wherein said angiography catheter is an inflatable balloon catheter, the balloon of which has a surface coated only with said coating.
2. The balloon catheter according to claim 1 , wherein (a) and (b) are coated onto the catheter using ethanol as solvent.
3. The catheter of claim 1 , wherein the agent is not enclosed by a solubility mediator in externally hydrophilic micelles.
4. The catheter of claim 1 , wherein said preparation additionally contains a coagulation inhibitor and/or a platelet aggregation inhibitor and/or an enzyme inhibitor and/or a calcium chelator.
5. The catheter of claim 1 , wherein at least 10% of the paclitaxel binds reversibly or irreversibly to tissue after contact between said coating and said tissue.
6. The catheter of claim 1 , wherein a component of the preparation shows a specific affinity towards vessel walls.
7. The catheter of claim 1 , wherein the preparation contains a non-micelle forming solubility mediator.
8. The catheter of claim 1 for restenosis prevention upon contact of said coating with tissue.
9. A catheter of claim 1 , wherein said paclitaxel is dissolved in said iopromide during preparation of said mixture.
10. A catheter of claim 1 wherein said balloon optionally carries a cardiovascular stent which is also optionally coated.
11. A catheter of claim 1 wherein said coating is preparable by immersing said balloon in said mixture prior to its drying.