Granted Patent B2

US 7,309,590 · App. 10/475,100 · Granted Dec 18, 2007

Abstract

Claims (19)

1. A method for producing an aqueous acrylamide solution, comprising:

forming a first mixture by mixing water and a biocatalyst in a reactor;

circulating the first mixture through the reactor and a pumping circuit with a pump, wherein the pumping circuit has at least one heat exchanger and a circuit with which said heat exchanger may be bypassed;

continuously adding acrylonitrile to the first mixture circulating through the pumping circuit and the reactor at a location after the heat exchanger and directly before the reactor to form a reaction mixture;

allowing the formation of acrylamide in said reaction mixture by the biocatalyst that catalyzes the conversion of acrylonitrile and water into the aqueous acrylamide solution;

cooling the reaction mixture by circulating the reaction mixture through the reactor and said pumping circuit; and

monitoring the course of the reaction by on-line measuring at least one of the acrylonitrile and acrylamide concentration flowing through the pumping circuit at a location before the addition of the acrylonitrile to the pumping circuit.

2. The method according to claim 1 , wherein the heat exchanger comprises external half-pipe coils.

3. The method according to claim 1 , wherein the heat exchanger is a shell-and-tube heat exchanger.

4. The method according to claim 1 , wherein the pump is a side channel pump.

5. The method according to claim 1 , wherein the acrylonitrile is added to the first mixture with a frequency-controlled piston-diaphragm pump.

6. The method according to claim 1 , wherein the first mixture is brought to a temperature of from 15 to 25° C. before adding the acrylonitrile to said first mixture.

7. The method according to claim 1 , further comprising regulating the cooling of the reaction mixture by the heat exchanger by flowing the reaction mixture through the bypass after the acrylonitrile addition is completed.

8. The method according to claim 1 , further comprising allowing the reaction to proceed for from 4 to 20 minutes after the acrylonitrile addition is completed.

9. The method according to claim 1 , further comprising allowing the reaction to proceed for from 5 to 10 minutes after the acrylonitrile addition is completed.

10. The method according to claim 1 , wherein the on-line measuring is carried out with a Fourier transform infrared (FT-IR) device.

11. The method according to claim 1 , further comprising controlling the course of reaction based on said on-line measurement.

12. The method according to claim 11 , wherein at least one of (i) the amount of acrylonitrile added, (ii) the flow through the pumping circuit, (iii) the flow through the bypass, and (iv) a secondary reaction time, are controlled.

13. The method according to claim 1 , wherein the biocatalyst is Rhodococcus rhodochrous , Deposit No. 14230 at DSMZ, Deutshe Sammlung von Mikroorganismen und Zellkulturen GmbH, Mashroder Weg 1B, D-38124 Braunshwig, Germany.

Assignments (24)