Process for the preparation of alkyl-n-(3-dimethylamino) alkylcarbamates
View Patent ↗This invention relates to a process for the preparation of alkyl-N-(3-dimethylamino)alkylcarbamates by reacting an alkyl-chloroformate in an alcohol.
1. A process for the preparation of an alkyl-N-(3-dimethylamino)alkylcarbamate which comprises reacting an alkyl-chloroformate with a 3-dimethylamino-alkylamine in an aliphatic (C 1 -C 6 ) alcohol or a mixture of one or more of such an alcohol with up to 30% by weight of water or inert organic solvents or mixtures thereof.
2. A process according to claim 1 for the preparation of n-propyl-3-(dimethylamino)n-propylcarbamate by using n-propyl chloroformate and 3 -dimethylamino-propylamine.
3. A process according to claim 2 in which n-propanol or recycled n-propanol is the aliphatic alcohol.
4. A process according to claim 1 wherein the reaction is run in a temperature range from about −20° C. to about 110° C.
5. A process according to claim 1 where both reagents can be used either stoichiometrically or in a molar excess up to 50%.
6. A process according to claim 1 where n-propyl chloroformate is used in a molar excess of up to 10%.
7. A process according to claim 2 wherein the reaction is run in a temperature range from about −20° C. to about 110° C.
8. A process according to claim 3 wherein the reaction is run in a temperature range from about −20° C. to about 110° C.