Method for the passivation of an intraocular lens
View Patent ↗The invention includes a method for the passivation of the surface of an intraocular lens, wherein the surface includes Brönsted sites. The intraocular lens is dipped into a solution of a fluoroalkyl silane having the general formula: R f —(CH 2 ) n —Si—(O—R) 3 . The residue R is selected from the group of H, CH 3 , C 2 H 5 and C 3 H 7 and the fluoroalkyl residue R f is selected from the series CF 3 (CF 2 ) m , with m=3 to 11 and n=0 to 4. The Brönsted sites on the surface are thereby deactivated by formation of Si—Q—bonds.
1. A method of modifying a surface of an intraocular lens, the surface of which comprises Brönsted sites, the method comprising contacting the surface of the lens with a solution of a fluoroalkyl silane of general formula
R F —(CH 2 ) n —Si—(O—R) 3
wherein R is selected from the group of H, CH 3 , C 2 H 7 , and R F is CF 3 (CF 2 ) m , with m=3 to 11 and n=0 to 4, whereby the fluoroalkyl silane is tethered to the surface by formation of Si—O—bonds at the Brönsted sites on the surface, and the modified surface of the intraocular lens has a fluorine content that is between 2% by weight and 15% by weight, and an oxygen content from 25.1% to 31.3% by weight, as measured by x-ray photoelectron spectroscopy.
2. The method according to claim 1 , wherein the intraocular lens is a silicone lens.
3. The method according to claim 1 , wherein the intraocular lens is a lens made of polymethylmethacrylate (PMMA) or acrylics.
4. The method according to claim 1 , wherein the solution is acidified and comprises between 0.5% by weight and 2% by weight of the fluoroalkyl silane.
5. The method according to claim 1 , wherein R f =CF 3 (CF 2 ) 5 , n=2 and R=CH 2 CH 3 .
6. The method according to claim 1 , wherein the Brönsted sites are formed by OH-groups.
7. The method according to claim 1 , wherein the Brönsted sites are formed by CO 2 -groups.
8. The method according to claim 1 , wherein the solution is acidified and comprises between 0.8% by weight and 1.2% by weight of the fluoroalkyl silane.
9. The method according to claim 1 , wherein the fluorine content is from 3.8% to 11.6% by weight.