IP Library Granted Patent US 8,021,683
Granted Patent B2
US 8,021,683 · App. 10/479,877 · Granted Sep 20, 2011

Wound dressing

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Quick Facts
Patent No.
US 8,021,683
App. No.
10/479,877
Granted
Sep 20, 2011
Kind
B2
Abstract

A composition comprising a non-volatile silicone fluid in admixture with fumed silica, a volatile diluent and a silicone elastomer.

Claims (40)

1. A wound dressing including a composition consisting of a non-volatile silicone fluid in admixture with fumed silica, a volatile diluent and a silicone elastomer.

2. A wound dressing as claimed in claim 1 wherein the silicone elastomer comprises a silicone cross-polymer.

3. A wound dressing as claimed in claim 2 wherein the silicone cross-polymer comprises a dimethicone cross-polymer.

4. A wound dressing as claimed in claim 1 wherein the silicone elastomer is in the form of a mixture comprising the silicone elastomer in a lower viscosity silicone fluid.

5. A wound dressing as claimed in claim 4 wherein the lower viscosity silicone fluid comprises a linear dimethicone or cyclomethicone.

6. A wound dressing as claimed in claim 4 wherein the mixture of silicone elastomer and lower viscosity silicone fluid has a viscosity of greater than of equal to 220,000 centistokes when measured at 25° C.

7. A wound dressing as claimed in claim 4 wherein the mixture of silicone elastomer and lower viscosity silicone fluid has a viscosity of less than or equal to 800,000 centistrokes when measured at 25° C.

8. A wound dressing as claimed in claim 4 wherein the mixture of silicone elastomer and lower viscosity silicone fluid is present in an amount of greater than or equal to 1% by weight of the composition.

9. A wound dressing as claimed in claim 4 wherein the mixture of silicone elastomer and lower viscosity silicone fluid is present in an amount of less than or equal to 10% by weight of the composition.

10. A wound dressing as claimed in claim 1 wherein the composition is a mixture comprising 15% by volume of the silicone elastomer and 85% by volume of a linear polydimethylsiloxane having a viscosity of 5 centistokes at 25° C. has a kinematic viscosity of greater than or equal to 220,000 centistokes when measured according to ASTM D-1084.

11. A wound dressing as claimed in claim 1 wherein the composition is a mixture comprising 15% by volume of the silicone elastomer and 85% by volume of a linear polydimethylsiloxane having a viscosity of 5 centistokes at 25° has a kinematic viscosity of greater than or equal to 800,000 centistokes when measured according to ASTM D-1084.

12. A wound dressing as claimed in claim 1 wherein the firmed silica is present in an amount of greater than or equal to 1% by weight of the composition.

13. A wound dressing as claimed in claim 1 wherein the volatile diluent is present in an amount of greater than or equal to 25% by weight of the composition.

14. A wound dressing as claimed in claim 1 wherein the volatile diluent comprises a volatile silicone fluid.

15. A wound dressing as claimed in claim 14 wherein the volatile silicone fluid comprises a silicone polymer.

16. A wound dressing as claimed in claim 1 wherein the non-volatile silicone fluid has a kinematic viscosity of less than or equal to 200,000 centistokes when measured at 25° C.

17. A wound dressing as claimed in claim 1 wherein the non-volatile silicone fluid comprises a silicone polymer.

18. A wound dressing as claimed in claim 1 wherein the non-volatile silicone fluid is present in an amount of greater than or equal to 20% by weight of the composition.

19. A wound dressing as claimed in claim 1 wherein the composition consists of:

1 to 5% by weight fumed silica; 35 to 65% by weight non-volatile silicone fluid;

25 to 65% by weight volatile diluent; and

1 to 5% by weight of a mixture of silicone elastomer and lower viscosity silicone fluid,

wherein the component parts of the composition total 100% by weight.

20. A wound dressing as claimed in claim 1 wherein the composition is in the form of a spreadable cream, gel, light grease or mobile spray on fluid.

21. A wound dressing including a composition consisting of a non-volatile silicone fluid in admixture with fumed silica, a volatile diluent, a silicone elastomer, and a pharmaceutical active agent.

22. A wound dressing as claimed in claim 21 wherein the pharmaceutical active agent is selected from antibiotic zeolites, chlorohexidine, polymyxin B sulphate, benzachromium, clindamycin, erythromycin, tetracycline, mupirocin, bacitracin zinc, neomycin sulphate, ibuprofen, naproxen, ketoprofen, flurbiprofen, acetyl salicylic acid or a combination thereof.

23. A wound dressing as claimed in claim 21 wherein the pharmaceutical active agent is selected from an antibacterial agent or from a non-steroidal anti-inflammatory drug.

24. A method of manufacturing a wound dressing as defined in claim 1 comprising contacting a non-volatile silicone fluid with fumed silica, a volatile diluent and a silicone elastomer.

25. A method for reducing scarring comprising administering a wound dressing as defined in claim 1 to a target tissue site.

26. A method for treating a wound comprising applying a wound dressing as defined in claim 21 to a wound.

27. A wound dressing as claimed in claim 1 , wherein the composition is self-drying.

28. A wound dressing as claimed in claim 15 wherein the silicone polymer comprises a cyclomethicone.

29. A wound dressing as claimed in claim 17 wherein the silicone polymer comprises a linear dimethicone.

30. A wound dressing as claimed in claim 21 further wherein the pharmaceutical active agent has antibacterial anti-inflammatory activity, antiviral activity, antifungal activity, or a combination thereof.

31. A wound dressing as claimed in claim 23 wherein the antibacterial agent comprises an antibiotic zeolite.

32. A wound dressing as claimed in claim 23 wherein the non-steroidal anti-inflammatory drug comprises acetyl salicylic acid.

33. A wound dressing including a composition consisting of a non-volatile silicone fluid in admixture with fumed silica, a volatile diluent, a silicone elastomer, and an antioxidant.

34. A method for preparing a wound dressing comprising providing a wound dressing including a composition consisting of a non-volatile silicone fluid in admixture with fumed silica, a volatile diluent and a silicone elastomer.

35. A method for preparing a wound dressing comprising providing a wound dressing including a composition consisting of a non-volatile silicone fluid in admixture with fumed silica, a volatile diluent, a silicone elastomer, and a pharmaceutical active agent.

36. A method for preparing a wound dressing comprising providing a wound dressing including a composition consisting of a non-volatile silicone fluid in admixture with fumed silica, a volatile diluent, a silicone elastomer, and an antioxidant.

Assignments (5)
RELEASE OF SECURITY INTEREST Recorded Jun 10, 2025
From: BANK OF SCOTLAND PLC
To: ADVANCED BIO-TECHNOLOGIES, INC.
Reel/Frame 071374/0859 →
SECURITY INTEREST Recorded Mar 4, 2016
From: ADVANCED BIO-TECHNOLOGIES, INC.
To: BANK OF SCOTLAND PLC
Reel/Frame 037894/0237 →
SECURITY AGREEMENT Recorded Jan 8, 2014
From: ADVANCED BIO-TECHNOLOGIES, INC.
To: HAYFIN SERVICES LLP
Reel/Frame 031940/0643 →
SECURITY AGREEMENT Recorded Dec 15, 2011
From: ADVANCED BIO-TECHNOLOGIES, INC.
To: CLYDESDALE BANK PLC
Reel/Frame 027389/0115 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 25, 2004
From: BERLAT, ALVIN
To: ADVANCED BIOTECHNOLOGIES, INC.
Reel/Frame 015032/0260 →