Wound dressing
View Patent ↗A composition comprising a non-volatile silicone fluid in admixture with fumed silica, a volatile diluent and a silicone elastomer.
1. A wound dressing including a composition consisting of a non-volatile silicone fluid in admixture with fumed silica, a volatile diluent and a silicone elastomer.
2. A wound dressing as claimed in claim 1 wherein the silicone elastomer comprises a silicone cross-polymer.
3. A wound dressing as claimed in claim 2 wherein the silicone cross-polymer comprises a dimethicone cross-polymer.
4. A wound dressing as claimed in claim 1 wherein the silicone elastomer is in the form of a mixture comprising the silicone elastomer in a lower viscosity silicone fluid.
5. A wound dressing as claimed in claim 4 wherein the lower viscosity silicone fluid comprises a linear dimethicone or cyclomethicone.
6. A wound dressing as claimed in claim 4 wherein the mixture of silicone elastomer and lower viscosity silicone fluid has a viscosity of greater than of equal to 220,000 centistokes when measured at 25° C.
7. A wound dressing as claimed in claim 4 wherein the mixture of silicone elastomer and lower viscosity silicone fluid has a viscosity of less than or equal to 800,000 centistrokes when measured at 25° C.
8. A wound dressing as claimed in claim 4 wherein the mixture of silicone elastomer and lower viscosity silicone fluid is present in an amount of greater than or equal to 1% by weight of the composition.
9. A wound dressing as claimed in claim 4 wherein the mixture of silicone elastomer and lower viscosity silicone fluid is present in an amount of less than or equal to 10% by weight of the composition.
10. A wound dressing as claimed in claim 1 wherein the composition is a mixture comprising 15% by volume of the silicone elastomer and 85% by volume of a linear polydimethylsiloxane having a viscosity of 5 centistokes at 25° C. has a kinematic viscosity of greater than or equal to 220,000 centistokes when measured according to ASTM D-1084.
11. A wound dressing as claimed in claim 1 wherein the composition is a mixture comprising 15% by volume of the silicone elastomer and 85% by volume of a linear polydimethylsiloxane having a viscosity of 5 centistokes at 25° has a kinematic viscosity of greater than or equal to 800,000 centistokes when measured according to ASTM D-1084.
12. A wound dressing as claimed in claim 1 wherein the firmed silica is present in an amount of greater than or equal to 1% by weight of the composition.
13. A wound dressing as claimed in claim 1 wherein the volatile diluent is present in an amount of greater than or equal to 25% by weight of the composition.
14. A wound dressing as claimed in claim 1 wherein the volatile diluent comprises a volatile silicone fluid.
15. A wound dressing as claimed in claim 14 wherein the volatile silicone fluid comprises a silicone polymer.
16. A wound dressing as claimed in claim 1 wherein the non-volatile silicone fluid has a kinematic viscosity of less than or equal to 200,000 centistokes when measured at 25° C.
17. A wound dressing as claimed in claim 1 wherein the non-volatile silicone fluid comprises a silicone polymer.
18. A wound dressing as claimed in claim 1 wherein the non-volatile silicone fluid is present in an amount of greater than or equal to 20% by weight of the composition.
19. A wound dressing as claimed in claim 1 wherein the composition consists of:
1 to 5% by weight fumed silica; 35 to 65% by weight non-volatile silicone fluid;
25 to 65% by weight volatile diluent; and
1 to 5% by weight of a mixture of silicone elastomer and lower viscosity silicone fluid,
wherein the component parts of the composition total 100% by weight.
20. A wound dressing as claimed in claim 1 wherein the composition is in the form of a spreadable cream, gel, light grease or mobile spray on fluid.
21. A wound dressing including a composition consisting of a non-volatile silicone fluid in admixture with fumed silica, a volatile diluent, a silicone elastomer, and a pharmaceutical active agent.
22. A wound dressing as claimed in claim 21 wherein the pharmaceutical active agent is selected from antibiotic zeolites, chlorohexidine, polymyxin B sulphate, benzachromium, clindamycin, erythromycin, tetracycline, mupirocin, bacitracin zinc, neomycin sulphate, ibuprofen, naproxen, ketoprofen, flurbiprofen, acetyl salicylic acid or a combination thereof.
23. A wound dressing as claimed in claim 21 wherein the pharmaceutical active agent is selected from an antibacterial agent or from a non-steroidal anti-inflammatory drug.
24. A method of manufacturing a wound dressing as defined in claim 1 comprising contacting a non-volatile silicone fluid with fumed silica, a volatile diluent and a silicone elastomer.
25. A method for reducing scarring comprising administering a wound dressing as defined in claim 1 to a target tissue site.
26. A method for treating a wound comprising applying a wound dressing as defined in claim 21 to a wound.
27. A wound dressing as claimed in claim 1 , wherein the composition is self-drying.
28. A wound dressing as claimed in claim 15 wherein the silicone polymer comprises a cyclomethicone.
29. A wound dressing as claimed in claim 17 wherein the silicone polymer comprises a linear dimethicone.
30. A wound dressing as claimed in claim 21 further wherein the pharmaceutical active agent has antibacterial anti-inflammatory activity, antiviral activity, antifungal activity, or a combination thereof.
31. A wound dressing as claimed in claim 23 wherein the antibacterial agent comprises an antibiotic zeolite.
32. A wound dressing as claimed in claim 23 wherein the non-steroidal anti-inflammatory drug comprises acetyl salicylic acid.
33. A wound dressing including a composition consisting of a non-volatile silicone fluid in admixture with fumed silica, a volatile diluent, a silicone elastomer, and an antioxidant.
34. A method for preparing a wound dressing comprising providing a wound dressing including a composition consisting of a non-volatile silicone fluid in admixture with fumed silica, a volatile diluent and a silicone elastomer.
35. A method for preparing a wound dressing comprising providing a wound dressing including a composition consisting of a non-volatile silicone fluid in admixture with fumed silica, a volatile diluent, a silicone elastomer, and a pharmaceutical active agent.
36. A method for preparing a wound dressing comprising providing a wound dressing including a composition consisting of a non-volatile silicone fluid in admixture with fumed silica, a volatile diluent, a silicone elastomer, and an antioxidant.