Topical pharmaceutical formulation

1. A wound dressing consisting of at least one non-volatile silicone fluid in admixture with fumed silica, one or more antibacterial active agent, and at least one volatile diluent.

2. The wound dressing of claim 1 , wherein said at least one non-volatile silicone fluid consists of a silicone polymer.

3. The wound dressing of claim 1 , wherein said at least one non-volatile silicone fluid is present in an amount of greater than or equal to 20% by weight of the wound dressing.

4. The wound dressing of claim 1 , wherein the blend of said at least one non-volatile silicone fluid and fumed silica consists of greater than or equal to 2% by weight fumed silica.

5. The wound dressing of claim 1 , wherein the blend of said at least one non-volatile silicone fluid and fumed silica consists of less than or equal to 12% by weight fumed silica.

6. The wound dressing of claim 1 , wherein said one or more antibacterial active agent is present in an amount of greater than or equal to 0.1% by weight of the wound dressing.

7. The wound dressing of claim 1 , wherein said one or more antibacterial active agent is present in an amount of less than or equal to 50% by weight of the wound dressing.

8. The wound dressing of claim 1 , wherein at least one of said one or more antibacterial active agent is in the form of a solid.

9. The wound dressing of claim 1 , wherein at least one of said one or more antibacterial active agent is an antibiotic zeolite.

10. The wound dressing of claim 9 , wherein the antibiotic zeolite consists of ion-exchangeable ions which have been totally or partially ion-exchanged with an antibiotic metal ion selected from the group consisting of silver ions, copper ions, zinc ions and a mixture thereof.

11. The wound dressing of claim 10 , wherein the antibiotic metal ions in the zeolite are present in an amount of greater than or equal to 0.1% by weight based on the weight of the zeolite.

12. The wound dressing of claim 10 , wherein the antibiotic metal ions in the zeolite are present in an amount of less than or equal to 15% by weight based on the weight of the zeolite.

13. The wound dressing of claim 1 , wherein said at least one volatile diluent consists of a volatile silicone fluid.

14. The wound dressing of claim 1 , wherein said at least one diluent is present in an amount of greater than 1% by weight of the wound dressing.

15. The wound dressing of claim 1 , wherein the viscosity of said one or more diluent is less than or equal to 10 mm 2 s −1 at 25° C. when measured by test method ASTM D-455.

16. The wound dressing of claim 1 , wherein upon evaporation of said at least one volatile diluent from the wound dressing, the resultant wound dressing has a higher viscosity.

17. The wound dressing of claim 1 , wherein said at least one non-volatile silicone fluid has a viscosity of less than or equal to 200,000 centistokes when measured at 25° C.

18. The wound dressing of claim 1 , wherein the wound dressing is in the form of a spreadable cream, gel, oil, light grease or mobile spray on fluid.

19. The wound dressing of claim 1 , consisting of:

1 to 5% by weight fumed silica;

35 to 65% by weight non-volatile silicone fluid;

25 to 65% by weight volatile diluent; and

1 to 5% by weight of an antibacterial active agent, wherein the component parts of the wound dressing total 100% by weight.

20. A method of manufacturing the wound dressing of claim 1 consisting of contacting an antibacterial active agent with a mixture of a non-volatile silicone fluid and fumed silica.

21. A method for the prophylactic treatment, therapeutic treatment or combination thereof of a tissue site infected by a pathogen, the method consisting of applying the wound dressing of claim 1 to the tissue site.

22. A method for the prophylactic treatment, therapeutic treatment or combination thereof of a scar consisting of applying the wound dressing of claim 1 to said scar.

23. A method for delivering a pharmaceutical active agent to a target tissue, the method consisting of administering the wound dressing of claim 1 to the target tissue.

24. The method of claim 23 , wherein the wound dressing is applied topically to the target tissue.

25. A method for reducing scarring, preventing scarring or a combination thereof consisting of administering the wound dressing of claim 1 to a tissue site.

26. A method for treating a wound consisting of applying the wound dressing of claim 1 to the wound.

27. A topical pharmaceutical delivery system consisting of the wound dressing of claim 1 .

28. An applicator comprising a reservoir consisting of the wound dressing of claim 1 , and a dispenser in fluid communication with the reservoir for dispensing the wound dressing from the reservoir.

29. The applicator of claim 28 wherein the dispenser consists of a spray, a roller ball, or a spatula.

30. The wound dressing of claim 2 , wherein the silicone polymer consists of a linear dimethicone.

31. The wound dressing of claim 2 , wherein the non-volatile silicone fluid is present in an amount of greater than or equal to 20% by weight of the wound dressing.

32. The wound dressing of claim 8 , wherein the solid consists of a powder.

33. The method of claim 21 , wherein the pathogen is bacteria or viruses.

34. The method for the prophylactic treatment, therapeutic treatment or combination thereof of a scar as claimed in claim 22 , wherein the wound dressing reduces scars, prevents scars or a combination thereof within a time of one month or less.

35. A method for reducing, preventing or ameliorating scarring of damaged tissue consisting of applying the wound dressing as defined in claim 1 .

36. A wound dressing consisting of at least one non-volatile silicone fluid in admixture with fumed silica, one or more antibacterial active agent, and at least one volatile diluent, said wound dressing being capable of ameliorating, preventing, or reversing the formation of scarring at a tissue site when said wound dressing is made to contact the site.

37. A method of manufacturing the wound dressing of claim 1 consisting of contacting an antibacterial active agent with a mixture of a non-volatile silicone fluid and fumed silica, and adding a diluent to the mixture thereof.