Method of manufacturing compound with biocatalyst by using controlled reaction temperature
View Patent ↗Provided is a method for producing a compound using a biocatalyst. In the method for continuously producing a compound using a biocatalyst in one or a plurality of reaction tanks, the downstream reaction temperature is set higher than the upstream reaction temperature of the flow of the catalyst in a reaction tank or between reaction tanks.
1. A method for continuously producing an amide compound in the presence of a biocatalyst in two or more reaction tanks, wherein a downstream reaction temperature is set higher than an upstream reaction temperature by at least 1° C. between reaction tanks.
2. The method according to claim 1 , wherein the downstream reaction temperature is set higher than the upstream reaction temperature by at least 5° C. between reaction tanks.
3. The method according to claim 1 , wherein the biocatalyst is microbial cells or a processed product thereof.
4. The method according to claim 1 , wherein the compound produced is acrylamide, nicotinamide, or 5-cyanovaleramide.
5. The method according claim 1 , wherein the biocatalyst flows in parallel with a flow of reaction solution in the reaction tanks.
6. The method according to claim 2 , wherein the biocatalyst is microbial cells or a processed product thereof.
7. The method according to claim 3 , wherein the biocatalyst is microbial cells.
8. The method according to claim 4 , wherein the biocatalyst is microbial cells or a processed product thereof.
9. The method according to claim 5 , wherein the biocatalyst is microbial cells or processed product thereof.
10. The method according claim 2 , wherein the biocatalyst flows in parallel with a flow of reaction solution in the reaction tanks.
11. The method according claim 3 , wherein the biocatalyst flows in parallel with a flow of reaction solution in the reaction tanks.
12. The method according claim 4 , wherein the biocatalyst flows in parallel with a flow of reaction solution in the reaction tanks.
13. The method according claim 5 , wherein the biocatalyst flows in parallel with a flow of reaction solution in the reaction tanks, and wherein said biocatalyst is a processed product of microbial cells.
14. The method according claim 6 , wherein the biocatalyst flows in parallel with a flow of reaction solution in the reaction tanks.
15. The method according claim 7 , wherein the biocatalyst flows in parallel with a flow of reaction solution in the reaction tanks.
16. The method according claim 8 , wherein the biocatalyst flows in parallel with a flow of reaction solution in the reaction tanks.
17. The method according claim 9 , wherein the biocatalyst flows in parallel with a flow of reaction solution in the reaction tanks.
18. The method of claim 1 , wherein the amide compound is acrylamide.