Compositions comprising thylakoids useful in the modulation of inflammation process
View Patent ↗A thylakoid extract that is preferably stabilized and activable for treating inflammation is described. Different types of cell or tissue targets and inflammatory stimuli have been used to evaluate the performance of the extract, which, in all cases successfully modulate inflammation through a balance of pro/anti-inflammatory cytokines. Compositions comprising the extract and other anti-inflammatory agents, such as glucocorticoids or non-steroidal anti-inflammatory drugs (NSAIDs) are further disclosed and claimed.
1. A method for modulating an inflammatory process in a subject, said method comnrising administering an effective amount of a thylakoid extract and an an effective amount an anti-inflammation agent to said subiect to modulate the inflammatory process.
2. The method of claim 1 , comprising modulating an amount of (a) pro-inflammatory cytokines, (b) anti-inflammatory cytokines or (c) both (a) and (b) induced during the inflammatory process.
3. The methoduse of claim 2 , wherein said pro-inflammatory cytokines comprise tumor necrosis factor-alpha (TNF-α).
4. The method of claim 2 , wherein said anti-inflammatory cytokines comprise interleukin-10.
5. The method of claim 2 , wherein the amount of anti-inflammatory cytokines is increased.
6. The method of claim 1 , wherein said anti-inflammatory agent is a glucocorticoid.
7. The method of claim 1 , wherein said anti-inflammatory agent is a non-steroidal anti-inflammatory drug (NSAID).
8. The method of claim 1 , wherein the extract is administered at a dose of about 0.00005 to 500 mg per kg of a subject's body weight.
9. The method of claim 1 , wherein the extract is administered at a dose of about 0.05 to 5 mg per kg of a subject's body weight.
10. The method of claim 1 , wherein the administration is topical.
11. The method of claim 10 , wherein said administration comprises about 0.1 μg to 1 mg of extract per cm 2 of surface of a subject's skin or mucosae.
12. The method of claim 10 , wherein said administration comprises about 1 μg to 200 μg of extract per cm 2 of surface of a subject's skin or mucosae.
13. A composition to inhibit inflammation in a subject, comprising an effective amount of an anti-inflammatory agent and an effective amount of a thylakoid extract.
14. The composition of claim 13 , wherein said anti-inflammatory agent is a glucocorticoid.
15. The composition of claim 13 , wherein said anti-inflammatory agent is a non-steroidal anti-inflammatory drug (NSAID).
16. The composition of claim 13 , which is topical.
17. The composition of claim 16 , wherein said effective amount of extract is about 0.1 μg to 1 mg per cm 2 of surface of a subject's skin or mucosae.
18. The composition of claim 16 , wherein said effective amount of extract is about 1 μg to 200 μg per cm 2 of a subject's surface of skin or mucosae.
19. The composition of claim 13 , wherein said effective amount of extract is about 0.00005 to 500 mg per Kg of a subject's body weight.
20. The composition of claim 13 , wherein said effective amount of extract is about 0.05 to 5 mg per Kg of a subject's body weight.
21. The composition of claim 13 , wherein said thylakoid extract comprises functional photosynthetic pigments.
22. The composition of claim 16 , wherein said effective amount of extract is about 0.00005 to 5%.