Pharmaceutically stable hemostatic compositions
View Patent ↗A novel hemostatic composition and a hemostatic pharmaceutical preparation are provided. A pharmaceutically stable hemostatic liquid composition comprising a mixed solution of activated blood coagulation factor VII (FVIIa) and blood coagulation factor X (FX) in a single container. The mixed solution is maintained at pH ranging from 5.0 to 6.5.
1. A pharmaceutically stable hemostatic liquid composition comprising a mixed solution of activated Factor VII (FVIIa) and Factor X (FX) in a pharmaceutically acceptable carrier in a single storage container, wherein the pH of the solution ranges from 5.0 to 6.5.
2. The pharmaceutically stable hemostatic liquid composition of claim 1 wherein said composition comprises FVIIa at 1 to 20 μM and EX at 5 to 400 μM.
3. A lyophilized hemostatic pharmaceutical preparation which is prepared by lyophilizing the pharmaceutically stable hemostatic liquid composition as set forth in claim 1 .
4. A method for stabilizing a liquid composition comprising a mixed solution of FVIIa and FX in a single container, which comprises adjusting said liquid composition to a pH ranging from 5.0 to 6.5 and maintaining said liquid composition at said pH.
5. A lyophilized hemostatic pharmaceutical preparation which is prepared by lyophilizing the pharmaceutically stable hemostatic liquid composition as set forth in claim 2 .