Radiolabeled neuropeptide Y Y5 receptor antagonists
View Patent ↗The present invention is directed to radiolabeled neuropeptide Y Y5 receptor antagonists which are useful for the labeling and diagnostic imaging of neuropeptide Y Y5 receptors in mammals.
1. A compound which is trans-N-[5-(2-fluorophenyl)-2-pyrimidinyl]-3-[ 11 C]-oxospiro[5-azaisobenzofurane-1(3H), 1′-cyclohexane]-4′-carboxamide or a pharmaceutically acceptable salt thereof.
2. A radiopharmaceutical composition which comprises the compound of claim 1 and at least one pharmaceutically acceptable carrier or excipient.
3. A method for the diagnostic imaging of neuropeptide Y Y5 receptors in a mammal which comprises administering to a mammal in need of such diagnostic imaging an effective amount of the compound of claim 1 .
4. The method of claim 3 wherein the mammal is a human.
5. A method for the diagnostic imaging of the brain in a mammal which comprises administering to a mammal in need of such diagnostic imaging an effective amount of the compound of claim 1 .
6. The method of claim 5 wherein the mammal is a human.
7. A method for the diagnostic imaging of tissues bearing neuropeptide Y Y5 receptors in a mammal which comprises administering to a mammal in need of such diagnostic imaging an effective amount of the compound of claim 1 .
8. The method of claim 7 wherein the mammal is a human.
9. A method for the quantification of neuropeptide Y Y5 receptors in mammalian tissue which comprises contacting such mammal tissue in which such quantification is desired with an effective amount of the compound of claim 1 .
10. The method of claim 9 wherein the mammalian tissue is human tissue.