Human cDNAs and proteins and uses thereof
View Patent ↗The invention concerns GENSET polynucleotides and polypeptides. Such GENSET products may be used as reagents in forensic analyses, as chromosome markers, as tissue/cell/organelle-specific markers, in the production of expression vectors. In addition, they may be used in screening and diagnosis assays for abnormal GENSET expression and/or biological activity and for screening compounds that may be used in the treatment of GENSET-related disorders.
1. A composition of matter comprising an isolated polypeptide comprising:
a) SEQ ID NO: 8;
b) a mature polypeptide consisting of amino acids 1 to 202 of SEQ ID NO: 8; or
c) the polypeptide of a) or b) further comprising a physiologically acceptable carrier.
2. The polypeptide of claim 1 , wherein said polypeptide belongs to the lipocalin superfamily.
3. The polypeptide of claim 2 , wherein said polypeptide is a splice variant of Alpha 1 Microglobulin.
4. The polypeptide of claim 1 , wherein said polypeptide is a plasma glycoprotein binding and transporting a small hydrophobic ligand selected from the group consisting of a steroid, a bilin, a retinoid and a lipid.
5. The polypeptide of claim 2 , wherein said polypeptide is a plasma glycoprotein binding and transporting a small hydrophobic ligand selected from the group consisting of a steroid, a bilin, a retinoid and a lipid.
6. The polypeptide of claim 3 , wherein said polypeptide is a plasma glycoprotein binding and transporting a small hydrophobic ligand selected from the group consisting of a steroid, a bilin, a retinoid and a lipid.