Coating material for leukocyte removal filter and the filter
View Patent ↗It is intended to provide a polymer for coating a leukocyte removal filter material which is excellent in the capability of removing leukocytes. It is further intended to provide a filter whereby both of leukocytes and platelets can be highly efficiently removed from a blood product containing leukocytes and platelets. The above objects can be achieved by using a polymer for coating a leukocyte removal filter material which comprises a unit originating in a hydrophobic polymerizable monomer, a unit originating in a polymerizable monomer containing a basic nitrogen-containing part, and a unit originating in a polymerizable monomer containing a protonic neutral hydrophilic part.
1. A filter for removing leukocytes and platelets, said filter having a polymer consisting of:
5-45 mol % of a unit originating from a hydrophobic polymerizable monomer selected from the group consisting of: methyl acrylate, methyl methacrylate, ethyl acrylate, ethyl methacrylate, butyl acrylate, butyl methacrylate, phenyl acrylate, phenyl methacrylate, ethylhexyl acrylate, ethylhexyl methacrylate, trichloroethyl acrylate, and trichloroethyl methacrylate;
1-15 mol % of a unit originating from a polymerizable monomer containing a basic nitrogen-containing part, wherein said polymerizable monomer is selected from the group consisting of: dimethylaminoethyl acrylate, dimethylaminoethyl methacrylate, diethylaminoethyl acrylate, diethylaminoethyl methacrylate, 3-dimethylamino-2-hydroxypropyl acrylate, and 3-dimethylamino-2-hydroxy propyl methacrylate; and
the balance of a unit originating from a polymerizable monomer containing a protonic neutral hydrophilic part, wherein said polymerizable monomer is 2-hydroxyethyl methacrylate or hydroxypropyl methacrylate,
wherein the filter has an average pore diameter of 1-60 μm, and
said polymer is present on the entire surface of the filter in an amount of 5-50 mg/m 2 per unit area of the filter surface.
2. The filter for removing leukocytes and platelets according to claim 1 , wherein the polymer is a vinyl polymer.
3. The filter for removing leukocytes and platelets according to claim 1 , wherein the basic nitrogen-containing part is a tertiary amino group.
4. The filter for removing leukocytes and platelets according to claim 1 , wherein the protonic neutral hydrophilic part is a hydroxyl group.
5. The filter for removing leukocytes and platelets according to claim 1 , wherein the filter material is a fibrous medium or a sponge-like structural material.
6. The filter for removing leukocytes and platelets according to claim 5 , wherein the filter material is a nonwoven fabric.
7. The filter for removing leukocytes and platelets according to claim 5 , wherein,
the filter material has a specific surface area of 1.0 m 2 /g or more and a void ratio of 70% or more,
the average fiber diameter is 0.3-3.0 μm, and
the filling density is 0.1-0.5 g/cm 3 .