1,3-glyceride compound having two iodophenyl groups
View Patent ↗A compound represented by the following general formula (I) or a salt thereof: wherein Ar 1 and Ar 2 independently represent a substituted or unsubstituted aryl group having at least one iodine atom as a substituent; L 1 and L 2 independently represent a divalent bridging group of which main chain consists of 7 or more atoms at least one of which is a heteroatom; and X represents —CH(OH)— or —CO—, which is suitable for an iodine-containing contrast medium containing liposomes.
1. A compound represented by the following general formula (I) or a salt thereof:
wherein Ar 1 and Ar 2 independently represent a substituted or unsubstituted aryl group having at least one iodine atom as a substituent; L 1 and L 2 independently represent a divalent bridging group having a main chain with a carbon number of 7-30 and containg at least one heteroatom; and X represents —CH(OH)— or —CO—.
2. The compound or a salt thereof according to claim 1 , wherein X is —CH(OH)—.
3. The compound or a salt thereof according to claim 1 , wherein Ar 1 and Ar 2 independently represent a phenyl group having at least three iodine atoms as substituents.
4. A liposome containing the compound or a salt thereof according to claim 1 as a membrane component.
5. The liposome according to claim 4 , which contains a combination of a phosphatidylcholine and a phosphatidylserine as membrane components.
6. A contrast medium for X-ray radiography, which comprises the liposome according to claim 4 .
7. The contrast medium for X-ray radiography according to claim 6 , which is used for radiography of a vascular disease.
8. The contrast medium for X-ray radiography according to claim 6 , which is used for radiography of vascular smooth muscle cells which are abnormally proliferated under an influence of foam macrophages.
9. The contrast medium for X-ray radiography according to claim 6 , which is used for radiography of a tissue or a lesion where macrophages localize.
10. The contrast medium for X-ray radiography according to claim 9 , wherein the tissue where macrophages localize is selected from the group consisting of tissues of liver, spleen, air vesicle, lymph node, lymph vessel, and renal epithelium.
11. The contrast medium for X-ray radiography according to claim 9 , wherein the lesion where macrophages localize is selected from the group consisting of lesions of tumor, inflammation, and infection.
12. A liposome containing the compound or a salt thereof according to claim 1 as a membrane component, wherein at least one of the iodine atoms is a radioisotope.
13. A contrast medium for scintigraphy, which comprises the liposome according to claim 12 .
14. The contrast medium for scintigraphy according to claim 13 , which is used for scintigraphy of vascular smooth muscle cells which are abnormally proliferated under an influence of foam macrophages.
15. The contrast medium for scintigraphy according to claim 13 , which is used for scintigraphy of a tissue or lesion where macrophages localize.
16. The contrast medium for scintigraphy according to claim 13 , wherein an objective tissue of scintigraphy is selected from the group consisting of tissues of blood vessel, liver, spleen, air vesicle, lymph node, lymph vessel, and renal epithelium.
17. The contrast medium for scintigraphy according to claim 13 , which is used for scintigraphy of a lesion selected from the group consisting of lesions of tumor, arteriosclerosis, inflammation, and infection.