17α-hydroxy-14β-steroids with hormonal effect
View Patent ↗This invention relates to steroidal compounds having the formula I wherein: R 1 is O, (H,H), (H,OH), NOH, whereby OH is optionally etherified or esterified; R 2 and R 3 are independently hydrogen or (C 1-4 ) alkyl and at least one of R 2 and R 3 is (C 1-4 ) alkyl; R 4 is hydrogen, or (C 1-15 ) acyl for use in androgen-related treatments, such as androgen insufficiency and male or female contraception.
1. A steroidal compound having the formula I
wherein:
R 1 is O, (H,H), (H,OH), NOH, whereby OH is optionally etherified or esterified;
R 2 and R 3 are independently hydrogen or (C 1-4 ) alkyl and at least one of R 2 and R 3 is (C 1-4 ) alkyl;
R 4 is hydrogen, or (C 1-5 ) acyl.
2. The steroidal compound according to claim 1 , wherein R 1 is O and least one of R 2 and R 3 is methyl and the other is hydrogen or methyl.
3. The steroidal compound according to claim 2 , wherein the compound is (7α,14β,16β,17α)-17-hydroxy-7,16-dimethylestr-4-en-3-one.
4. A method of male contraception or male or female hormone replacement therapy, comprising:
administering an effective amount of the compound according to claim 1 .
5. A method of treatment of an animal or a human person in need of androgenic stimulation for an androgenic effect, comprising:
administering an effective dose of the steroidal compound according to claim 1 to the animal or human person.
6. A pharmaceutical composition, comprising:
the compound according to claim 1 , and
pharmaceutically acceptable auxiliaries.