Dry powder medicament formulations
A dry powder pharmaceutical composition comprising (i) a medicament particle fraction comprising medicament particles with an aerodynamic diameter no greater than 10 μm; and (ii) at least 50% of a non-respirable excipient fraction comprising low density excipient particles with an aerodynamic diameter greater than 10 μm and a geometric diameter greater than 30 μm. In additional embodiments of the invention, the pharmaceutical composition includes a respirable excipient fraction comprising excipient particles with an aerodynamic diameter no greater than 10 μm. In a preferred embodiment of the invention, the non-respirable excipient particles include pores adapted to receive a portion of the respirable excipient fraction and/or the medicament fraction.
1. A pharmaceutical composition obtained by providing medicament particles having an aerodynamic diameter no greater than 10 μm,
providing first excipient particles having an aerodynamic diameter no greater than 10 μm,
providing second excipient particles and having an aerodynamic diameter greater than 10 μm and a geometric diameter from 90 μm to 150 μm,
preblending said medicament particles and said first excipient particles to form a medicament/excipient composition, and wherein a portion of said first excipient particles are disposed in said defining said pores during said pre-blending step, and
blending said second excipient particles and said medicament/excipient composition;
wherein said pharmaceutical composition is present in the form of a dry powder.
2. The pharmaceutical composition according to claim 1 , wherein the medicament particles comprise a medicament selected from the group consisting of an analgesic, anginal preparation, antiallergic, antibiotic, antiinfective, antihistamine, anti-inflammatory, antitussive, bronchodilator, α 4 integrin inhibitor, diuretic, anticholinergic, adenosine 2a agonists, hormones, xanthine, vaccine, therapeutic protein, peptide, and combinations thereof.
3. The pharmaceutical composition according to claim 1 , wherein the first excipient particles comprise at least one excipient selected from the group consisting of sugars, lubricants, fatty acids, amino acids, stearates and their salts or esters, calcium salts, derivatives thereof, and biocompatible polymers.
4. The pharmaceutical composition according to claim 1 , wherein the first excipient particles comprise at least one excipient selected from the group consisting of mannitol, lactose, phenylalanine, glycine, leucine, dibasic calcium phosphate, tribasic calcium phosphate, polylactic acid (PLA), polylactic-coglycolic acid (PLGA), diketopiperazine, calcium stearate, sodium stearyl fumarate, and magnesium stearate.
5. The pharmaceutical composition according to claim 1 , wherein the second excipient particles comprise at least one excipient selected from the group consisting of carbohydrates, amino acids, fatty acids, bio-compatible polymers, and inorganic salts.
6. The pharmaceutical composition according to claim 1 , wherein the second excipient particles comprise at least one excipient selected from the group consisting of lactose, mannitol, maltose, maltodextrins, dextrose, phenylalanine, leucine, glycine, diketopiperazine, calcium stearate, sodium stearyl fumarate, polylactic acid (PLA), polylactic-coglycolic acid (PLGA), and a calcium salt.
7. A process for producing a pharmaceutical composition, comprising the steps of:
providing medicament particles having an aerodynamic diameter no greater than 10 μm;
providing first excipient particles having an aerodynamic diameter no greater than 10 μm;
providing second excipient particles including defining pores and having an aerodynamic diameter greater than 10 μm and a geometric diameter from 90 μm to 150 μm;
preblending said first and second excipient particles to form an excipient composition, wherein a portion of said first excipient particles are disposed in said pores; and
blending said medicament particles and said excipient composition to form a pharmaceutical composition present in the form of a dry powder.