Method for improving dissolution of poorly dispersible medicaments
The present invention is to provide a method for improving the dissolution of a poorly dispersible medicament and that is achieved by preparing a granulated product where a floating agent is added to the poorly dispersible medicament.
1 - 18 . (Canceled).
19 . A granulated product where dissolution of a poorly dispersible medicament is improved, which comprises the poorly dispersible medicament and a floating agent, wherein the dissolution of the poorly dispersible medicament is improved by the floating agent.
20 . The granulated product according to claim 19 , which further comprises a surfactant.
21 . The granulated product according to claim 20 , wherein the granulated product is manufactured by an extrusion granulation.
22 . The granulated product according to claim 20 , wherein the granulated product is in a form of fine granules.
23 . A capsule which comprises the granulated product described in claim 20 .
24 . A tablet which comprises the granulated product described in claim 20 .
25 . The granulated product according to claim 20 , wherein the floating agent is non-water-soluble cellulose, sodium alginate, propylene glycol alginate, tragacanth powder or xanthan gum.
26 . The granulated product according to claim 20 , wherein the surfactant is sodium lauryl sulfate, polyoxyl 40 stearate, sucrose fatty acid ester, polyoxyethylene hydrogenated castor oil, polyoxyethylene polyoxypropylene glycol or polyoxyethylene sorbitan fatty acid ester.
27 . The granulated product according to claim 20 , wherein the poorly dispersible medicament is 11-[4-[2-(2-hydroxyethoxy)ethyl]-1-piperazinyl]-dibenzo[b,f][1,4]thiazepine or a salt thereof.
28 . The granulated product according to claim 27 , wherein the floating agent is crystalline cellulose and the surfactant is sodium lauryl sulfate.
29 . The granulated product according to claim 28 , wherein the granulated product is manufactured by an extrusion granulation.
30 . The granulated product according to claim 28 , wherein the granulated product is in a form of fine granules.