Silver salts of sucrose-octasulphate
View Patent ↗The described invention relates to the new compound “sucrose-octasulphate salified with silver” usefully applicable in the prevention and cure of infections by micro-organisms of bacterial, fungal, viral and/or yeast origins and in the promotion of tissue repair. The silver salts of sucrose octasulphate, subject of the invention have in fact been shown to possess antimicrobial activities even higher than that of known silver compounds. These properties therefore make them particularly suitable for use in different pathological or paraphysiological conditions of the skin, of the epithelia and of the mucosa both intact and lesioned.
1. Compound of formula (I)
wherein R is SO 3 − Ag + .
2. A topical parapharmaceutical cosmeceutical or cosmetic composition comprising the compound of formula (I)
wherein R is SO 3 − Ag + .
3. Compositions comprising, as principal active ingredient, the compound of formula (I)
wherein R is SO 3 − Ag +
in combination with excipients and/or diluents suitable for topical cutaneous, epithelial and mucosal administration.
4. The compositions according to claim 3 , in which the compound is combined with excipients and/or diluents suitable for topical cutaneous, epithelial and mucosal administration as it is or encapsulated in nanospheres and/or microspheres.
5. The compositions according to claim 3 in which the compositions are solutions or aqueous, non aqueous, hydroalcoholic suspensiions, drops, gels, emulsions, creams, ointments, ovules, powder sprays, sprays with or without propellants, and foams.
6. The compositions according to claim 3 in which the compound is supported on inert biocompatible systems selected from the group consisting of: films, membranes, patches and dressings, also with slow release.
7. Compositions according to claims 3 or 4 in which the compound is incorporated into biomaterials selected from the group constituted by hydrogels, membranes, sponges, or into materials dissolving rapidly in aqueous environments.
8. A method for prevention and/or cure of infections of bacterial, fungal, viral or yeast origin and in the promotion/acceleration of tissue repair in pathologies of the skin, mucosa and/or oral cavity, and external and internal genitalia and ocular epithelia both intact and lesioned comprising the application of a pharmaceutical composition comprising a compound of formula (I) to the infected area, wherein said compound of formula (I) is:
wherein R is SO 3 − Ag + .
9. The method according to claim 8 , wherein the pathologies are selected from the group consisting of: candidiasis, acne, herpes, papilloma virus diseases; superficial and deep wounds, internal and external, grazes and abrasions, lacerated/contused wounds, wounds with soft tissue loss, strongly exudating wounds, both chronic and acute, surgical wounds, traumas; superficial and deep burns; vascular trophic lesions, ischemic ulcers, vascular ulcers, diabetic ulcers, stasis ulcers, corneal ulcers; bedsores; athletes foot; and abscesses.
10. Process for the preparation of compound of formula (I)
wherein R is SO 3 − Ag+
characterised by the fact of comprising at least two distinct steps which consist of: a) preparation of sucrose-octosulphate acid starting from a salt of sucrose-octosulphate; b) neutralisation, under controlled conditions up to pH 7,2, of the sucrose-octosulphate acid with Ag ion bases.
11. Process for the preparation of the compound of formula (I)
wherein R is SO 3 − Ag +
characterised by the fact of comprising at least three distinct steps which consist of: a) preparation of sucrose-octosulphate acid starting from a salt of sucrose-octosulphate; b) preparation of a resin derivatised with Ag ions and c) passing the sucrose-octosulphate acid obtained in step a) through the column obtained in step b).
12. Process for the preparation of the compound of formula (I)
wherein R is SO 3 − Ag +
characterised by the fact of comprising of a single step of direct exchange between monovalent salts of sucrose-octosulphate and salts of Ag with anions selected from the group constituted by tetrafluoroborate, nitrate, perchlorate and carbonate.
13. The process according to claim 12 in which the anion selected is tetrafluoroborate.