Oxindole hydrazide modulators of protein tyrosine phosphatases (PTPs)

1. An oxindole hydrazide of formula (II)

wherein A is O or a bond;

B is independently optionally substituted phenyl, naphthyl, phenantrenyl, pyrrolyl, furyl, thienyl, imidazolyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, pyrazolyl, [1,3]thiazolo [3,2-b][1,2,4]triazolyl, carbazolyl, 1,2,3-triazolyl, 1,2,4-triazolyl, 1,2,3-oxadiazolyl, benzo (2, 1, 3) oxadiazolyl, benzo (1,2,5) oxadiazolyl, 1,2,4-oxadiazolyl, 1,2, 5-oxadiazolyl, 1,3,4-oxadiazolyl, tetrazolyl, 1,3,4-triazinyl, 1,2,3-triazinyl, benzofuryl, [2,3- dihydro]benzofuryl, isobenzofuryi, benzothienyl, benzotriazolyl, isobenzothienyl, indolyl, isoindolyl, 3H-indolyl, benzimidazolyl, benzothiazolyl, benzoxazolyl, pyridazinyl, pyrirnidyl, quinolizinyl, quinazolinyl, pthalazinyl, quinoxalinyl, cinnolinyl, napthyridinyl, quinolyl, isoquinolyl, tetrazolyl, 5,6,7,8-tetrahydroquinolyl, 5,6,7,8-tetrahydroisoquinolyl, purinyl, pteridinyl, carbazolyl, xanthenyl, benzoquinolyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclooctyl, oxolanyl, pyrolidinyl, pyrazolidinyl, piperidinyl, piperazinyl, pyridyl, imidazolidinyl, 1,2,4-oxadiazolidinyl, 1,2,5-oxadiazolidinyl, 1,3,4-oxadiazolidinyl, isoxazolidinyl or morpholinyl;

R 8 is selected in the group consisting of H, halogen, cyano, (C 1 -C 6 )alkyl, aryl, heteroaryl, —SO—R 9 , —SO 2 —R 9 ,(C 1 -C 6 )alkyl-SO 2 —R 9 , —NO 2 , —N(R 9 ) 2 , (C 1 -C 6 )-alkyl-O—R 9 , —SR 9 , —SO 2 —R 9 , —(C═O)O—R 9 , —(C═O)—R 9 , —(C═O)N(R 9 ) 2 , —(C═O)NH—R 9 , —(C═O)NR 9 —N(R 9 ) 2 , —NR 9 —(C═O)—N(R 9 ) 2 , —NR 9 —(SO 2 —R 9 ), —NH—(C═O)—R 9 , (C 1 -C 6 )-alkyl-NH—(C═O)—R 9 , —NR 9 —(C═O)—R 9

wherein R 9 is selected from the group consisting of H, C 3 -C 8 cycloalkyl, 3-8 membered heterocycloalkyl which may contain 1-2 further heteroatoms selected from O, N or S, (C 1 -C 6 )-alkyl-heterocycloalkyl wherein said heterocycloalkyl may contain 1-2further heteroatoms selected from O, N or S, aryl, (C 1 -C 6 )-alkyl-aryl, (C 1 -C 6 )-alkoxy-aryl, heteroaryl, (C 1 -C 6 )-alkyl-heteroaryl or (C 1 -C 6 )-alkoxy-heteroaryl, (C 1 -C 6 )-alkyl, (C 1 -C 6 )-alkyl-COOR 10 wherein R 10 is H or (C 1 -C 6 )alkyl or —NH 2

m′ is 0 or 1;

p is an integer from 1 to 3;

with the proviso that the following compounds are excluded:

2. An oxindole hydrazide according to claim 1 , wherein B is a phenyl group and m′ is 0.

3. An oxindole hydrazide according to claim 2 wherein m′ is 0, p is 0 or 1, A is a bond or O, B is a phenyl group and R 8 is selected in the group consisting of —O 2 , —CO 2 —R 9 and —NH—(C═O)—R 9 wherein R 9 is selected from the group consisting of H, C 3 -C 8 cycloalkyl, 3-8 membered heterocycloalkyl which may contain 1-2 further heteroatoms selected from O , N or S, (C 1 -C 6 )-alkyl-heterocycloalkyl wherein said heterocycloalkyl may contain 1-2 further heteroatoms selected from O, N or S, aryl, (C 1 -C 6 )-alkyl-aryl, (C 1 -C 6 )-alkoxy-aryl, heteroaryl, (C 1 -C 6 )-alkyl-heteroaryl or (C 1 -C 6 )-alkoxy-heteroaryl, (C 1 -C 6 )-alkyl, (C 1 -C 6 )-alkyl-COOR 10 wherein R 10 is H or (C 1 -C 6 )alkyl or —NH 2 .

4. An oxindole hydrazide according to claim 1 , wherein said oxindole hydrazide is selected from the group consisting of:

N-(4-{[2-(5-Iodo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)hydrazino]carbonyl}phenyl) -3-phenylpropanamide;

3,5-Dichloro-N′-(5-iodo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)benzohydrazide;

N′-(5-Iodo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)benzohydrazide;

N′-(5-Iodo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-4-methylbenzohydrazide;

4-Hydroxy-N′-(5-iodo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)benzohydrazide;

3-Hydroxy-N′-(5-iodo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)benzohydrazide;

N′-(5-Iodo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-2-nitrobenzohydrazide;

N′-(5-Iodo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-4-phenoxybenzohydrazide;

N′-(5-Iodo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-4-(trifluoromethyl) benzohydrazide;

4-tert-Butyl-N′-(5-Iodo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)benzohydrazide;

N′-(5-Iodo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)[1,1′-biphenyl]-4-carbohydrazide;

4-Bromo-N′-(5-iodo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)benzohydrazide;

N′-(5-Iodo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-3-nitrobenzohydrazide;

N′-(5-Iodo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-4-methoxybenzohydrazide;

N′-(5-Iodo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-3-methoxybenzohydrazide;

4-Amino-N′-(5-iodo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)benzohydrazide;

4-(Dimethylamino)-N′-(5-iodo-2-oxo-1,2-dihydro-3H-indol-3-lidene)benzohydrazide;

N′-(5-Iodo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-2-(4-nitrophenoxy) acetohydrazide;

N′-(5-Iodo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-4-(trifluoromethoxy) benzohydrazide;

N′-(5-Iodo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-2,1,3-benzoxadiazole-5-carbohydrazide;

N′-(5-Iodo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-((5-nitro)-2-furohydrazide);

Methyl 4-{[2-(5-iodo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)hydrazino]carbonyl}benzoate;

Methyl 4-{2-[2-(5-iodo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)hydrazino]-2-oxoethoxy}benzoate;

4-{[2-(5-Iodo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)hydrazino]carbonyl}benzoic acid;

4-Iodo-N′-(5-Iodo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)benzohydrazide;

N′-(5-Iodo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-3-phenoxybenzohydrazide;

N′-(5-Iodo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-2-(4-iodophenoxy)acetohydrazide;

N′-(5-Iodo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-2-[(4-methylphenyl) sulfonyl]acetohydrazide;

2-{[(2-Furylmethyl)sulfonyl]methyl}-N′-(5-iodo-2-oxo-1,2-dihydro-3H-indol-3-ylidene) -1,3-thiazole-4-carbohydrazide;

2-Hydroxy-N′-(-5-iodo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)benzohydrazide;

N-(2-Furylmethyl)-N′-{2-[2-(5-iodo-2-oxo-1,2-dihydro-3H-indol-3-ylidene) hydrazino]-2-oxoethyl}urea;

N′-(5-Iodo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-4-(methylsulfanyl) benzohydrazide;

Methyl 6-{[2-(5-iodo-2-oxo-1,2-dihydro-3H-indol-3-ylidene) hydrazino]carbonyl}nicotinate;

Benzyl 4-{2-[2-(5-iodo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)hydrazine]-2-oxoethoxy}benzoate;

N-(4-{[2-(5-Iodo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)hydrazino]carbonyl}phenyl)-2-furamide;

N-(4-{[2-(5-Iodo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)hydrazino]carbonyl}phenyl)hexanamide;

4-Cyano-N-(4-{[2-(5-iodo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)hydrazino]carbonyl}phenyl)benzamide;

4-(Hexyloxy)-N-(4-{[2-(5-iodo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)hydrazino]carbonyl}phenyl)benzamide;

4-Heptyl-N-(4-{[2-(5-iodo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)hydrazino]carbonyl}phenyl)benzamide;

2-{2-Nitro-4,5-dimethoxyphenyl}-N′-[5-iodo-2-oxo-1,2-dihydro-3H-indol-3-yliden)acetohydrazide;

N′-(5-Iodo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-1-(3-pyridinylmethyl)-4-piperidinecarbohydrazide;

2-Amino-5-nitro-N′-(5-iodo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)benzohydrazide;

2-[5-(3-Nitrophenyl)-2H-tetrazo1-2-yl]-N′-(5-iodo-2-oxo 1,2-dihydro-3H-indol-3-ylidene)acetohydrazide;

N′-(5-Iodo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-2-[5-( 1-pyrrolidinyl)-2H-tetrazol-2-yl]acetohydrazide;

N′-(5-Iodo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-2-[5-(4-morpholinyl)-2H-tetrazol-2-yl]acetohydrazide;

4-{2-[2-(5-Iodo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)hydrazino]-2-oxoethoxy}benzoic acid;

4-{[2-(5-Iodo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)hydrazino]carbonyl}-N-phenylbenzamide;

4-Cyano-N-(3-{[2-(5-iodo-2-oxo-1,2-dihydro-3H-indol-3-ylidene) hydrazino]carbonyl}phenyl)benzamide;

N′-[5-Iodo-2-oxo-1,2-dihydro-3H-indol-3-ylidene]-4-[4-(4-morpholinylmethyl) phenoxy]benzohydrazide;

N-(4-{[2-(5-Iodo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)hydrazino]carbonyl}phenyl) benzamide;

4-(Benzyloxy)-N′-(5-iodo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)benzohydrazide;

N-(3-{[2-(5-Iodo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)hydrazino]carbonyl}phenyl)-3-phenyipropanamide;

4-{[2-(5-Iodo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)hydrazino]carbonyl}-N-{3-[(trifluoromethyl)sulfonyl]phenyl}benzamide;

4-Chloro-N-(4-{[2-(5-iodo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)hydrazino]-carbonyl }benzyl)benzamide;

Methyl 4-{3-[2-(5-iodo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)hydrazino]-3-oxopropyl }benzoate;

2-[(2-Chlorophenoxy)methyl]-N′-(5-iodo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-1,3-thiazole-4-carbohydrazide;

N′-(5-Iodo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-2-(2-phenyl[1,3]thiazolo[3 ,2-b][1,2,4]triazol-6-yl)acetohydrazide;

4-{[3-Chloro-5-(trifluoromethyl)-2-pyridinyl]amino}-N′-[5-iodo-2-oxo-1,2-dihydro-3H-indol-3-ylidene]butanohydrazide;

2-{[3-Chloro-5-(trifluoromethyl)-2-pyridinyl]amino}-N′-(5-iodo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)acetohydrazide;

1-Benzoyl-N′-(5-iodo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-4-piperidinecarbohydrazide;

N-(4-{[2-(5-Iodo-2-oxo-1,2-dihydro-3H-indol-3- ylidene) hydrazino]carbonyl}phenyl)-2-phenoxyacetamide;

N-(4-{[2-(5-Iodo-2-oxo-1,2-dihydro-3H-indol-3- ylidene)hydrazino]carbonyl}phenyl)-nicotinamide;

3-Nitro-N-(4-{[2-(5-iodo-2-oxo-1,2-dihydro-3H-indol-3-ylidene) hydrazino]carbonyl}-benzyl)benzamide;

N-(4-{[2-(5-Iodo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)hydrazino]carbonyl}-phenyl)[1,1′-biphenyl]-4-carboxamide;

Methyl-3-{2-[2-(5-iodo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)hydrazino]-2-oxoethoxy }benzoate;

Methyl-4-{[[2-(5-iodo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)hydrazino](oxo)acetyl]-amino }benzoate;

3-(1,3-Benzodioxol-5-yl)-N-(4-{[2-(5-iodo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-hydrazine ]carbonyl}phenyl)propanamide;

4-[(4-{[2-(5-Iodo-2-oxo-1,2-dihydro-3H-indol-3-ylidene) hydrazino]carbonyl}benzoyl)-amino]benzoic acid;

3-(3,4-Dihydroxyphenyl)-N-(4-{[2-(5-iodo-2-oxo-1,2-dihydro-3H-indol-3-ylidene) hydrazino]carbonyl}phenyl)propanamide;

3-(3-Hydroxyphenyl)-N-(4-{[2-(5-iodo-2-oxo-1,2-dihydro-3H-indol-3-ylidene) hydrazino]-carbonyl}phenyl)propanamide;

N′-(5-Iodo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-6-methoxy-5-nitronicotinohydrazide;

3-{[2-(5-Iodo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)hydrazino]sulfonyl}benzoic acid;

2-Hydroxy-5-{[2-(5-iodo-2-oxo-1,2-dihydro-3H-indol-3-ylidene) hydrazino]sulfonyl}-benzoic acid;

N′-(5-Iodo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-5-(2-pyridinyl)-2-thiophenesulfono-hydrazide;

4-Chloro-N′-(5-iodo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-3-nitrobenzenesulfono-hydrazide;

Methyl-{3-[(4-hydroxybenzoyl)hydrazono]-5-iodo-2-oxo-2,3-dihydro-1H-indol-1-yl }acetate;

N-Dodecyl-3-[(4-hydroxybenzoyl)hydrazono]-5-iodo-2-oxo-2,3-dihydro-1H-indole-1-carboxamide;

Methyl-(3-{[4-(hexanoylamino)benzoyl]hydrazono}-5-iodo-2-oxo-2,3-dihydro-1H-indol-1-yl)acetate;

(3-{[4-(hexanoylamino)benzoyl]hydrazono}-5-iodo-2-oxo-2,3-dihydro-1H-indol-1-yl) acetic acid;

(3-{[4-(hexanoylamino)benzoyl]hydrazono}-5-iodo-2-oxo-2,3-dihydro-1H-indol-1-yl) acetic acid, tromethanine (2-amino-2-hydroxymethyl-1,3-propanediol) salt;

(3-{[4-(hexanoylamino)benzoyl]hydrazono}-5-iodo-2-oxo-2,3-dihydro-1H-indol-1-yl) acetic acid, N-methyl-D-glucamine (1-deoxy-1-(methylamino)glucitol) salt;

2-(4-cyanophenoxy)-N′-(5-iodo-2-oxo-1,2-dihydro-3H-indol-3-ylidene) acetohydrazide;

4-({2-[2-(5-iodo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)hydrazino]-2-oxoethyl}thio)-3-nitrobenzenesulfonamide;

N-(4-{[2-(5-iodo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)hydrazino]carbonyl}phenyl)-N-methyl-3-phenyipropanamide;

methyl-{3-[(4-{[3-(1,3-benzodioxol-5-yl)propanoyl]amino}benzoyl)hydrazono]-5-iodo-2-oxo-2,3-dihydro-1H-indol-1-yl}acetate;

methyl-4-[(4-{[2-(5-iodo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)hydrazino]carbonyl}-phenyl)amino]-4-oxobutanoate;

3-(1,3-benzodioxol-5-yl)-N-(4-{[2-(5-bromo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-hydrazine ]carbonyl}phenyl)propanamide;

{3-[(4-{[3-(1,3-benzodioxol-5-yl)propanoyl]amino}benzoyl)hydrazono]-5-iodo-2-oxo-2,3-dihydro-1H-indol-1-yl}acetic acid;

{3-[(4-{[3-(1,3-benzodioxol-5-yl)propanoyl]amino}benzoyl)hydrazono]-5-iodo-2-oxo-2,3-dihydro-1H-indol-1-yl}acetic acid, N-methyl-D-glucamine (1-deoxy-1-(methylamino) glucitol)salt;

methyl-6-[(4-{[2-(5-iodo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)hydrazino]carbonyl}-phenyl)amino]-6-oxohexanoate;

methyl-4-{[(4-{[2-(5-iodo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)hydrazino]carbonyl}-phenyl)amino]carbonyl}benzoate;

methyl-8-[(4-{[2-(5-iodo-2-oxo-1,2-dihydro-3H-indol-3-ylidene) hydrazino]carbonyl}-phenyl)amino]-8-oxooctanoate;

methyl-5-[(4-{[2-(5-iodo-2-oxo-1,2-dihydro-3H-indol-3-ylidene) hydrazino]carbonyl}-phenyl)amino]-5-oxopentanoate;

8-[(4-{[2-(5-iodo-2-oxo-1,2-dihydro-3H-indol-3-ylidene) hydrazino]carbonyl}phenyl)-amino]-8-oxooctanoic acid;

8-[(4-{[2-(5-iodo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)hydrazino]carbonyl}phenyl)-amino]-8-oxooctanoic acid, N-methyl-D-glucamine (1-deoxy-1-(methylamino)glucitol) salt;

6-[(4-{[2-(5-iodo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)hydrazino]carbonyl}phenyl)-amino]-6-oxohexanoic acid;

6-[(4-{[2-(5-iodo-2-oxo-1,2-dihydro-3H-indol-3-ylidene) hydrazino]carbonyl}phenyl)-amino]-6-oxohexanoic acid, N-methyl-D-glucamine (1- deoxy-1-(methylamino)glucitol) salt;

4-[(4-{[2-(5-iodo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)hydrazino]carbonyl}phenyl)-amino]-4oxobutanoic acid;

4-{[(4-{[2-(5-iodo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)hydrazine]carbonyl}benzyl)-amino]carbonyl}benzoic acid, N-methyl-D-glucamine (1-deoxy-1-(methylamino)-glucitol) salt;

5-[(4-{[(2-(5-iodo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)hydrazino]carbonyl}phenyl)-amino]-5-oxopentanoic acid;

5-[(4-{[(2-(5-iodo-2-oxo-1,2-dihydro-3H-indol-3-ylidene) hydrazino]carbonyl}phenyl)-amino]-5-oxopentanoic acid, N-methyl-D-glucamine (1-deoxy-1-(methylamino)glucitol) salt;

4-{[(4-{[2-(5-iodo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)hydrazino]carbonyl}phenyl)-amino]carbonyl}benzoic acid;

4-{[(4-{[2-(5-iodo-2-oxo-1,2-dihydro-3H-indol-3-ylidene) hydrazino]carbonyl}phenyl)-amino]carbonyl}benzoic acid, N-methyl-D-giucamine (1-deoxy-1-(methylamino)-glucitol) salt;

methyl-4-{[(4-{[2-(5-iodo-2-oxo-1,2-dihydro-3H-indol-3-ylidene) hydrazino]carbonyl}-benzyl)amino]carbonyl}benzoate;

4-{[(4-{[2-(5-iodo-2-oxo-1,2-dihydro-3H-indol-3-ylidene) hydrazino]carbonyl}benzyl)-amino]carbonyl}benzoic acid;

4-{[(4-{[2-(5-iodo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)hydrazine]carbonyl}benzyl)-amino]carbonyl}benzoic acid, N-methyl-D-glucamine (1-deoxy-1-(methylamino)-glucitol) salt;

benzyl-(2S)-2-(4-{[2-(5-iodo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)hydrazino]-carbonyl}phenoxy)-3-phenylpropanoate;

(2S)-2-(4-{[2-(5-iodo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)hydrazino]carbonyl}-phenoxy)-3-phenyipropanoic acid;

(2S)-2-(4-{[2-(5-iodo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)hydrazino]carbonyl}-phenoxy)-3-phenyipropanoic acid, N-methyl-D-glucamine (1-deoxy-1-(methylamino) glucitol) salt;

methyl-4-{3-[(4-{[3-(1,3-benzodioxol-5-yl)propanoyl]amino }benzoyl)hydrazonoll-5-iodo-2-oxo-2,3-dihydro-1H-indol-1-yl}butanoate;

4-{3-[(4-{[3-(1,3-benzodioxol-5-yl)propanoyl]amino }benzoyl)hydrazono]-5-odo-2-oxo-2,3-dihydro-1H-indol-1-yl}butanoic acid;

4-{3-[(4-{[3-(1,3-benzodioxol-5-yl)propanoyl]amino }benzoyl)hydrazono]-5-iodo-2-oxo-2,3-dihydro-1H-indol-1-yl}butanoic acid, N-methyl-D-glucamine (1-deoxy-1-(methylamino)glucitol) salt;

methyl-3-(4-{[(4-{[2-(5-iodo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)hydrazino]-carbonyl}phenyl)amino]sulfonyl}phenyl)propanoate;

3-(4-{[(4-{[2-(5-iodo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)hydrazino]carbonyl}-phenyl)amino]sulfonyl}phenyl) propanoic acid; and

3-(4-{[(4-{[2-(5-iodo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)hydrazino]carbonyl }-phenyl)amino]sulfonyl}phenyl) propanoic acid, N-methyl-D-glucamine (1-deoxy-1-(methylamino) glucitol) salt.

5. An oxindole hydrazide selected from the group consisting of:

4-Nitro-N′-(5-bromo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)benzohydrazide;

Methyl-4-{2-[2-(5-bromo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)hydrazino]-2-oxoethoxy}benzoate;

4-Methoxy-N′-(5-bromo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)benzohydrazide;

N-(4-{[2-(5-Bromo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)hydrazino]carbonyl }phenyl)-3-phenylpropanamide;

N′-(5-Bromo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-4-{3-[2-(5-bromo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)hydrazino]-3-oxopropyl }benzohydrazide;

N-(4-{[2-(5-Bromo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)hydrazino]carbonyl }-phenyl)-2-phenoxyacetamide;

N-(4-{[2-(5-Bromo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)hydrazino]carbonyl}-benzyl)-3-nitrobenzamide;

Methyl 3-{2-[2-(5-bromo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)hydrazino]-2-oxoethoxy}benzoate;

N′-(5-Bromo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-2-[4-( 1H-tetrazol-5-yl)phenoxy]acetohydrazide; and

N′-(5-Bromo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-4-(1H-tetrazol-5-yl)benzohydrazide.

6. An oxindole hydrazide of formula (II):

wherein A is O or a bond;

wherein B is selected from the group consisting of phenyl, biphenyl, benzo (1,2,5) oxadiazolyl, furyl, thiadiazolyl, thienyl, thiazolyl, indolyl, piperidinyl, tetrazolyl, 1,2,3-triazolyl, 1,2,4-triazolyl and pyridyl;

R 8 is selected in the group consisting of H, halogen, cyano, (C 1 -C 6 )alkyl, aryl, heteroaryl, —SO—R 9 , —SO 2 , —R 9 , (C 1 -C 6 )alkyl-SO 2 —R 9 , —NO 2 , —N(R 9 ) 2 , (C 1 -C 6 )-alkyl-O—R 9 , —SR 9 , —SO 2 —R 9 , —(C═O)O—R 9 , —(C═O)—R 9 , —(C═O)N(R 9 ) 2 , —(C═O)NH—R 2 , —(C═O)NR 9 —N(R 9 ) 2 , —NR 9 —(C═O)—N(R 9 ) 2 , —NR 9 —(SO 2 —R 9 ), —NH—(C═O)—R 9 , (C 1 -C 6 )-alkyl-NH—(C═O)-R 9 , —NR 9 —(C═O)—R 9

wherein R 9 is selected from the group consisting of H, C 3 -C 8 cycloalkyl, 3-8 membered heterocycloalkyl which may contain 1-2 further heteroatoms selected from O, N or S, (C 1 -C 6 )-alkyl-heterocycloalkyl wherein said heterocycloalkyl may contain 1-2 further heteroatoms selected from O, N or S, aryl, (C 1 -C 6 )-alkyl-aryl, (C 1 -C 6 )-alkoxy-aryl, heteroaryl, (C 1 -C 6 )-alkyl-heteroaryl or (C 1 -C 6 )-alkoxy-heteroaryl, (C 1 -C 6 )-alkyl, (C 1 -C 6 )-alkyl-COOR 10 wherein R 10 is H or (C 1 -C 6 )alkyl or —NH 2

m′ is 0 or 1;

p is an integer from 1 to 3;

with the proviso that the following compounds are excluded:

7. A pharmaceutical composition comprising at least one oxindole hydrazide according to claim 1 , and a pharmaceutically acceptable carrier, diluent or excipient thereof.

8. A method of preparing an oxindole of formula (I) according to claim 1 ,

which comprises:

reacting A and B as follows:

9. A method according to claim 8 , wherein compound B is prepared by a process, which comprises:

reacting (C) with PG-NH—NH—R 3 as follows:

wherein R is C 1 -C 6 alkyl group and PG, R, A, B, R 8 m, n and p are as above defined.