Estrogenic compounds in combination with progestogenic compounds in hormone-replacement therapy
One aspect of the present invention relates to a method of hormone replacement in mammals, which method comprises the oral administration of an estrogenic component and a progestogenic component to a mammal in an effective amount to prevent or treat symptoms of hypoestrogenism, wherein the estrogenic component is selected from the group consisting of substances represented by the above formula in which formula R 1 , R 2 , R 3 , R 4 independently are a hydrogen atom, a hydroxyl group or an alkoxy group with 1-5 carbon atoms; each of R 5 , R 6 , R 7 is a hydroxyl group; and no more than 3 of R 1 , R 2 , R 3 , R 4 are hydrogen atoms; precursors capable of liberating a substance according to the aforementioned formula when used in the present method; and mixtures of one or more of the aforementioned substances and/or precursors. Another aspect of the invention concerns a pharmaceutical kit comprising oral dosage units that contain the aforementioned estrogenic component and a progestogenic component as well as an androgenic component.
1. A method of hormone replacement in mammals comprising orally administering an estrogenic component and a progestogenic component to a mammal in an effective amount to treat symptoms of hypoestrogenism, the estrogenic component being selected from the group consisting of estetrol;
precursors capable of liberating estetrol when used in the present method, which precursors are derivatives of estetrol, wherein the hydrogen atom of at least one of the hydroxyl groups has been substituted by an acyl radical of a hydrocarbon carboxylic, sulfonic or sulfamic acid of 1-25 carbon atoms; tetrahydrofuranyl; tetrahydropyranal; or a straight or branched chain glycosidic residue containing 1-20 glycosidic units per residue; and
mixtures of estetrol and the precursors.
2. The method according to claim 1 , wherein the symptoms of hypoestrogenism are selected from the group consisting of osteoporosis, arteriosclerosis, climacteric symptoms, cognitive disturbances and Alzheimer's disease.
3. The method according to claim 1 , wherein the method comprises the daily oral administration of the estrogenic component during a period of at least 10 days.
4. The method according to claim 3 , wherein the method comprises the daily oral administration, during a period of at least 10 days, of a combination of the estrogenic component and a progestogenic component.
5. The method according to claim 4 , wherein the method comprises the daily oral administration of the combination of the estrogenic component and the progestogenic component during a period of at least 28 days.
6. The method according to claim 4 , wherein the method further comprises an interval of at least 2 days during which no progestogenic component and no estrogenic component is administered and wherein the resulting decrease in serum concentration of the progestogenic component and the estrogenic component induces menses.
7. The method according to claim 4 , wherein the method comprises the daily oral administration of the estrogenic component during a period of at least 28 days and wherein, following the combined administration of the estrogenic component and the progestogenic component, the estrogenic component and no progestogenic component are administered during 3-18 consecutive days and the resulting decrease in serum concentration of the progestogenic component induces menses.
8. The method according to claim 1 , wherein the method comprises the at least once daily oral administration of the estrogenic component and the progestogenic component during a period of at least 10 days.
9. The method according to claim 1 , wherein the estrogenic component is orally administered in an amount of less than 1 mg per kg of bodyweight per day.
10. The method according to claim 1 , wherein the estrogenic component is orally administered in an amount of at least 1 μg per kg of bodyweight per day.
11. The method according to claim 1 , wherein the progestogenic component is administered in an amount which is equivalent to a daily oral dosage of 0.3 to 20 μg levonorgestrel per kg of bodyweight.
12. A pharmaceutical kit comprising at least 20 oral dosage units that contain the estrogenic component as defined in claim 1 and/or the progestogenic component as defined in claim 1 and/or an androgenic component, wherein at least 10 units contain between 0.01 and 20 mg of the estrogenic component, at least 10 units contain the progestogenic component in an amount equivalent to 30-750 μg levonorgestrel and at least 10 dosage units contain the androgenic component in an amount equivalent to 5-250 mg dehydroepiandrosterone.
13. The pharmaceutical kit according to claim 12 , comprising at least 10 oral dosage units that contain between 0.01 and 20 mg of the estrogenic component, the progestogenic component in an amount equivalent to 30-750 μg levonorgestrel and the androgenic component in an amount equivalent to 5-250 mg dehydroepiandrosterone.
14. The pharmaceutical kit according to claim 12 , wherein the androgenic component is selected from the group consisting of dehydroepiandrosterone (DHEA), danazol, gestrinone, testosterone esters, precursors capable of liberating these androgens when used in the present method and mixtures thereof.