Filter for selectively eliminating leukocytes
View Patent ↗It is intended to provide a filter for selectively removing leukocytes whereby leukocytes can be selectively and efficiently removed without worsening in the performance due to sterilization while causing little elution and minimizing loss in platelets. Namely, a filter for selectively removing leukocytes which is highly tolerant to sterilization and contains a polymer on the filter surface, characterized in that the polymer consists of a hydroxyalkyl (meth)acrylate unit having 3 or 4 carbon atoms in the alkyl moiety, a monomer unit having a basic nitrogen-containing functional group, and a monomer unit having an ethylene oxide chain with a repetition number of 2 to 9, the content of the monomer unit having the basic nitrogen-containing functional group ranges from 2% by mol to 9% by mol in the polymer, and the ethylene oxide chain content ranges from 1% by weight to 10% by weight in the polymer.
1. A filter material for selectively removing leukocytes with excellent sterilization resistance comprising a polymer on the surface of a filter base material, wherein the polymer is formed from a hydroxyalkyl (meth)acrylate unit with the alkyl moiety having 3 or 4 carbon atoms, a monomer unit having a basic nitrogen-containing functional group, and a monomer unit containing an ethylene oxide chain with 2-9 ethylene oxide repetitions, wherein the content of the monomer unit having a basic nitrogen-containing functional group in the polymer is 2-9 mol % and the content of the ethylene oxide chain in the polymer is 1-10 wt %.
2. The filter material according to claim 1 , wherein the polymer is a vinyl-type polymer.
3. The filter material according to claim 1 , wherein the hydroxyalkyl (meth)acrylate unit is hydroxypropyl methacrylate.
4. The filter material according to claim 1 , wherein the number of ethylene oxide repetitions in the ethylene oxide chain is 2.
5. The filter material according to claim 1 , wherein the weight average molecular weight of the polymer is 100,000-500,000 and the content of the polymer having a weight average molecular weight of 10,000 or less is less than 10 wt %.
6. The filter material according to claim 1 , wherein the ratio of the content of the ethylene oxide chain in the polymer to the weight average molecular weight of the polymer is from 3.5×10 −6 to 40×10 −6 .
7. The filter material according to claim 1 , wherein the amount of the polymer introduced per unit surface area of the filter base material is 90-300 mg/m 2 .
8. The filter material according to claim 1 , which is used for selectively removing leukocytes from human whole blood.
9. The filter material according to claim 2 , wherein the hydroxyalkyl (meth)acrylate unit is hydroxypropyl methacrylate.
10. A filter material for selectively removing leukocytes with excellent sterilization resistance, comprising:
a polymer on the surface of a filter base material, wherein the polymer is formed from a hydroxyalkyl (meth)acrylate unit with the alkyl moiety having 3 or 4 carbon atoms, a monomer unit having a basic nitrogen-containing functional group, and a monomer unit containing an ethylene oxide chain with 2-9 ethylene oxide repetitions;
wherein the content of the monomer unit having a basic nitrogen-containing functional group in the polymer is 2-9 mol % and the content of the ethylene oxide chain in the polymer is 1-10 wt %;
wherein the weight average molecular weight of the polymer is 100,000-500,000 and the content of the polymer having a weight average molecular weight of 10,000 or less is less than 10 wt %; and
wherein the amount of the polymer introduced per unit surface area of the filter base material is 90-300 mg/m 2 .
11. The filter material according to claim 10 , wherein the polymer is a vinyl-type polymer.
12. The filter material according to claim 10 , wherein the hydroxyalkyl (meth)acrylate unit is hydroxypropyl methacrylate.
13. The filter material according to claim 11 , wherein the hydroxyalkyl (meth)acrylate unit is hydroxypropyl methacrylate.
14. The filter material according to claim 10 , wherein the number of ethylene oxide repetitions in the ethylene oxide chain is 2.
15. The filter material according to claim 11 , wherein the number of ethylene oxide repetitions in the ethylene oxide chain is 2.