Solid compositions containing compounds unstable to oxygen and method for stabilization thereof
The present invention aims at stabilizing a solid composition containing a nitrogenous fused-heterocycle compound unstable to oxygen to provide a stable pharmaceutical preparation. The stabilization can be attained by keeping the equilibrium moisture content at 10% or above and/or adding ascorbic acid or a salt thereof, by preliminarily applying a film coating free from light blocking agents, or by applying one or more packaging selected from among oxygen-barrier packaging, inert gas replacement packaging, vacuum packaging and sealing packaging with an oxygen absorber.
1 . A solid composition containing a fused nitrogen-containing heterocyclic compound unstable to oxygen, which is stabilized by
[1] maintaining an equilibrium moisture content of 10% or above in the solid composition and/or
[2] incorporating ascorbic acid or a salt thereof in the solid composition.
2 . The solid composition according to claim 1 , wherein the fused nitrogen-containing heterocyclic compound is a compound represented by the formula:
wherein, ring A is an optionally substituted benzene ring; ring B is a 4 to 7-membered nitrogen-containing heterocyclic ring which may be optionally substituted with halogen, an optionally substituted heterocyclic ring or an optionally substituted hydrocarbon group in addition to D; and D is a hydrogen atom, a heterocyclic group which may be optionally substituted and may optionally have a fused ring, or an optionally substituted hydrocarbon group, or a salt thereof.
3 . The solid composition according to claim 1 , wherein the fused nitrogen-containing heterocyclic compound is an isoindoline compound.
4 . The solid composition according to claim 3 , wherein the fused nitrogen-containing heterocyclic compound is (R)-(+)-5,6-dimethoxy-2-[2,2,4,6,7-pentamethyl-3-(4-methylphenyl)-2,3-dihydro-1-benzofuran-5-yl]isoindoline, (R)-(+)-5,6-dimethoxy-2-[2,2,4,6,7-pentamethyl-3-(1-methylethylphenyl)-2,3-dihydro-1-benzofuran-5-yl]isoindoline, (R)-(+)-5,6-dimethoxy-2-[2,2,4,6,7-pentamethyl-3-(4-bromophenyl)-2,3-dihydro-1-benzofuran-5-yl]isoindoline, or a salt thereof.
5 . The solid composition according to claim 2 , which is coated with a film for protection from light.
6 . The solid composition according to claim 5 , which is precoated with a film that does not contain a light blocking agent.
7 . A packed product obtained by packing the solid composition according to any one of claims 1 to 6 in one or more packaging forms selected from oxygen permeation-suppressing package, gas-replacement package, vacuum package and sealing package with an oxygen scavenger.
8 . A packed product obtained by packing a solid composition in nitrogen-replacement package, wherein the solid composition comprises a compound represented by the formula:
wherein, ring A is an optionally substituted benzene ring; ring B is a 4 to 7-membered nitrogen-containing heterocyclic ring which may be optionally substituted with halogen, an optionally substituted heterocyclic ring or an optionally substituted hydrocarbon group in addition to D; and D is a hydrogen atom, a heterocyclic group which may be optionally substituted and may optionally have a fused ring, or an optionally substituted hydrocarbon group, or a salt thereof, and ascorbic acid or a salt thereof; is coated with a film for protection from light without being precoated with a film; and has an equilibrium moisture content of 10% or above.
9 . A method for stabilizing a solid composition containing a fused nitrogen-containing heterocyclic compound unstable to oxygen, which comprises
[1] maintaining an equilibrium moisture content of 10% or above in the solid composition,
[2] incorporating ascorbic acid or a salt thereof in the solid composition, and/or
[3] packing the solid composition in one or more packaging forms selected from oxygen permeation-suppressing package, gas-replacement package, vacuum package and sealing package with an oxygen scavenger.
10 . The method according to claim 9 , wherein the fused nitrogen-containing heterocyclic compound is a compound represented by the formula:
wherein, ring A is an optionally substituted-benzene ring; ring B is a 4 to 7-membered nitrogen-containing heterocyclic ring which may be optionally substituted with halogen, an optionally substituted heterocyclic ring or an optionally substituted hydrocarbon group in addition to D; and D is a hydrogen atom, a heterocyclic group which may be optionally substituted and may optionally have a fused ring, or an optionally substituted hydrocarbon group, or a salt thereof.
11 . The method according to claim 9 , wherein the fused nitrogen-containing heterocyclic compound is an isoindoline compound.
12 . The stabilization method according to claim 9 , wherein the fused nitrogen-containing heterocyclic compound is (R)--(+)-5,6-dimethoxy-2-[2,2,4,6,7-pentamethyl-3-(4-methylphenyl)-2,3-dihydro-1-benzofuran-5-yl]isoindoline, (R)-(+)-5,6-dimethoxy-2-[2,2,4,6,7-pentamethyl-3-(1-methylethylphenyl)-2,3-dihydro-1-benzofuran-5-yl]isoindoline, (R)-(+)-5,6-dimethoxy-2-[2,2,4,6,7-pentamethyl-3-(4-bromophenyl)-2,3-dihydro-1-benzofuran-5-yl]isoindoline or a salt thereof.
13 . A stabilized solid composition which comprises [1] a compound unstable to oxygen and [2] an antioxidant that is less oxidizable than said compound and wherein an equilibrium moisture content of 10% or above is maintained.
14 . A packed product obtained by packing the composition according to claim 13 in one or more packaging forms selected from oxygen permeation-suppressing package, gas-replacement package, vacuum package, and sealing package with an oxygen scavenger.
15 . A method for stabilizing a solid composition containing a compound unstable to oxygen, which comprises
[1] maintaining an equilibrium moisture content of 10% or above in the solid composition,
[2] incorporating an antioxidant that is less oxidizable than the compound in the solid composition, and/or
[3] packing the solid composition in one or more packaging forms selected from oxygen permeation-suppressing package, gas-replacement package, vacuum package, and oxygen scavenger-enclosed package.