IP Library Granted Patent US 7,296,895
Granted Patent B2
US 7,296,895 · App. 10/498,455 · Granted Nov 20, 2007

Sequential scanning wavefront measurement and retinal topography

View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 7,296,895
App. No.
10/498,455
Granted
Nov 20, 2007
Kind
B2
Abstract

An improved sequential scanning method and apparatus for measuring wavefront aberration involves angularly displacing a measurement beam from a parallel beam striking the corneal surface at a desired location and using the displacement of an image on a detector between the angularly displaced beam and a reference beam to obtain a more accurate wavefront measurement than provided by the displacement between the parallel beam and a reference beam conventionally used for such wavefront aberration measurement. A method and related apparatus for determining a retinal topography relies on using the improved measurement method and apparatus in conjunction with other ocular data to determine changes in the bulbous length of the eye based upon retinal image displacement.

Claims (26)

1. In a method for measuring a wavefront aberration of an eye in which a first, reference, object beam projected parallel to a known reference axis is input to the eye at a first, reference location (P 1 ) on a cornea of the eye such that the first beam is scattered from a location ( 1 ) on the retinal surface and further imaged onto a detector at a reference position (x 1 , y 1 ), and at least a sequential, second object beam parallel to and displaced a known amount (d) from the reference beam is projected into the eye at a second location (P 2 ) on the cornea, is scattered from a location ( 2 ) on the retinal surface and further imaged onto the detector at a second position (x 2 , y 2 ), such that a displacement (Δx 2−1 , Δy 2−1 ) can be measured and from which wavefront aberration information can be calculated, the improvement characterized by:

inputting a third beam corresponding to each sequential second beam at an angle (α) to the reference axis that enters the cornea at the same location as each second beam (P 2 ) and is scattered from a location ( 3 ) on the retinal surface substantially corresponding to location ( 1 ) and further imaged onto the detector at a third position (x 3 , y 3 ), such that a displacement (Δx 3−1 , Δy 3−1 ) can be measured and the wavefront aberration calculated corresponding to location P 2 on the cornea,

whereby the wavefront aberration for cornea location P 2 from the third beam data is more accurate than the corresponding measurement from the second beam measurement.

2. The method of claim 1 , wherein the input beams each have a diameter between about 0.2 to 2 mm.

3. The method of claim 1 , wherein the input beams each have a diameter between about 0.4 to 0.5 mm.

4. The method of claim 1 , wherein the input beams have a wavelength between about 400 to 1200 nm.

5. The method of claim 1 , wherein the input beams have a wavelength between about 700 to 900 nm.

6. The method of claim 1 , wherein the reference axis is a fixating visual axis of the eye.

7. The method of claim 1 , wherein the reference axis is an optical axis of the eye.

8. The method of claim 1 , further comprising inputting a sufficient number of second and third input beams at different corneal locations (P n ) to wavefront map a desired surface area of the cornea.

9. In an improved sequential scanning device for making a wavefront measurement of an eye, wherein the device includes means for sequentially inputting a reference light beam into the eye at a selected location on a cornea of the eye having a propagation path coincident with a reference axis, and a plurality of measurement light beams into the eye at selected locations on the cornea having propagation paths that are mutually parallel and parallel to the reference axis; means for capturing light from each of the input beams scattered from different locations of a retinal surface of the eye and imaging said light at a desired external location; a detector for receiving said imaged light and detecting a displacement of the image from a reference image; and calculation means for calculating wavefront aberration information from the image displacement that corresponds to the input location on the cornea, the improvement comprising:

means for sequential inputting a plurality of additional measurement beams, each of which corresponds to a measurement beam, into the eye at locations on the cornea that correspond to the measurement beams and which strike the retinal surface at a location substantially where the reference beam strikes the retinal surface, such that each of the additional measurement beams are imaged on the detector at a displacement from the reference image, and wherein the calculation means calculates the wavefront aberration information from the additional image displacement corresponding to the input locations on the cornea.

10. A method for determining a topographic variation of a retinal surface of an eye comprising:

inputting a first object beam projected parallel to a known reference axis to the eye at a first location (P 1 ) on a cornea of the eye such that the first beam is scattered from a location ( 1 ) on the retinal surface and further imaged onto a detector at a reference position (x 1 , y 1 );

inputting a second object beam parallel to and displaced a known amount (d) from the reference beam to the eye at a second location (P 2 ) on the cornea, wherein it is scattered from a location ( 2 ) on the retinal surface and further imaged onto a detector at a second position (x 2 , y 2 );

making a first spherical refractive error measurement corresponding to (Δx 2−1 , Δy 2−1 );

inputting a third beam to the eye at a selected angle (α) to the reference axis at the same location as the second beam (P 2 ) which is scattered from a location ( 3 ) on the retinal surface substantially corresponding to location ( 1 ) and further imaged onto the detector at a third position (x 3 , y 3 );

making a second spherical refractive error measurement corresponding to (Δx 3−1 , Δy 3−1 ); and

determining, for a ΔX 2−1 displacement on the retinal surface, a Δ1 change in the length of the eye.

11. The method of claim 10 , comprising sequentially inputting a plurality of second and third beams corresponding to a plurality of locations on the corneal surface.

12. A device that provides retinal topography information, comprising:

means for sequentially inputting a reference light beam into an eye at a selected location on a cornea of the eye having a propagation path coincident with a reference axis, and a plurality of measurement light beams into the eye at selected locations on the cornea having propagation paths that are mutually parallel and parallel to the reference axis;

means for capturing light from each of the input beams scattered from different locations of the retinal surface of the eye and imaging said light at a desired external location;

a detector for receiving said imaged light and detecting a displacement of the image from a reference image;

calculation means for calculating wavefront aberration information from the image displacement that corresponds to the input location on the cornea;

means for sequential inputting a plurality of additional measurement beams, each of which corresponds to a measurement beam, into the eye at locations on the cornea that correspond to the measurement beams and which strike the retinal surface at a location substantially where the reference beam strikes the retinal surface, such that each of the additional measurement beams are imaged on the detector at a displacement from the reference image, and wherein the calculation means calculates the wavefront aberration information from the additional image displacement corresponding to the input locations on the cornea, further wherein the calculation means uses the wavefront aberration information from the additional image displacement and ocular parametric information for mapping the retinal topography.

Assignments (16)
RELEASE OF SECURITY INTEREST Recorded Nov 20, 2025
From: THE BANK OF NEW YORK MELLON, AS NOTES COLLATERAL AGENT
To: ATON PHARMA, INC.; BAUSCH & LOMB INCORPORATED; BAUSCH & LOMB PHARMA HOLDINGS CORP.; COMMONWEALTH LABORATORIES, LLC; DOW PHARMACEUTICAL SCIENCES, INC.; ECR PHARMACEUTICALS CO., INC.; LABORATOIRE CHAUVIN S.A.S.; MEDICIS PHARMACEUTICAL CORPORATION; ONPHARMA INC.; ORAPHARMA, INC.; PRECISION DERMATOLOGY, INC.; SALIX PHARMACEUTICALS, LTD.; SALIX PHARMACEUTICALS, INC.; SANTARUS, INC.; SOLTA MEDICAL, INC.; SYNERGETICS USA, INC.; TECHNOLAS PERFECT VISION GMBH; VALEANT CANADA LP; VALEANT PHARMACEUTICALS INTERNATIONAL; VALEANT PHARMACEUTICALS INTERNATIONAL, INC.; VALEANT PHARMACEUTICALS NORTH AMERICA LLC; WIRRA IP PTY LIMITED; VALEANT PHARMA POLAND SP. Z O.O.; VALEANT PHARMACEUTICALS LUXEMBOURG S.A R.L.; VALEANT PHARMACEUTICALS IRELAND LIMITED
Reel/Frame 073637/0001 →
RELEASE OF SECURITY INTEREST Recorded Apr 8, 2025
From: BARCLAYS BANK PLC, AS COLLATERAL AGENT
To: SOLTA MEDICAL, INC.; PRECISION DERMATOLOGY, INC.; BAUSCH HEALTH IRELAND LIMITED (F/K/A/ VALEANT PHARMACEUTICALS IRELAND LIMITED); SALIX PHARMACEUTICALS, INC.; SALIX PHARMACEUTICALS, LTD; SANTARUS, INC.; MEDICIS PHARMACEUTICAL CORPORATION; HUMAX PHARMACEUTICAL S.A.; SOLTA MEDICAL IRELAND LIMITED; BAUSCH & LOMB MEXICO, S.A. DE C.V.; BAUSCH+LOMB OPS B.V.; BAUSCH HEALTH AMERICAS, INC.; BAUSCH HEALTH COMPANIES INC.; BAUSCH HEALTH HOLDCO LIMITED; BAUSCH HEALTH MAGYARORSZAG KFT (A/K/A BAUSCH HEALTH HUNGARY LLC); BAUSCH HEALTH POLAND SPOLKA Z OGRANICZONA ODPOWIEDZIALNOSCIA (F/K/A VALEANT PHARMA POLAND SPOLKA Z OGRANICZONA ODPOWIEDZIALNOSCIA); BAUSCH HEALTH US, LLC; BAUSCH HEALTH, CANADA INC. / SANTE BAUSCH, CANADA INC.; ICN POLFA RZESZOW SPOLKA AKCYJNA (A/K/A ICN POLFA RZESZOW S.A.); ORAPHARMA, INC.; PRZEDSIEBIORSTWO FARMACEUTYCZNE JELFA SPOLKA AKCYJNA (A/K/A PRZEDSIEBIORSTWO FARMACEUTYCZNE JELFA S.A.); SOLTA MEDICAL DUTCH HOLDINGS B.V.; V-BAC HOLDING CORP.; VRX HOLDCO LLC; 1261229 B.C. LTD.; 1530065 B.C. LTD.
Reel/Frame 070778/0199 →
OMNIBUS PATENT SECURITY RELEASE AGREEMENT (REEL/FRAME 045444/0634) Recorded Nov 2, 2022
From: THE BANK OF NEW YORK MELLON
To: BAUSCH & LOMB INCORPORATED; LABORATOIRE CHAUVIN S.A.S.; TECHNOLAS PERFECT VISION GMBH; THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
Reel/Frame 061872/0295 →
RELEASE OF SECURITY INTEREST IN SPECIFIED PATENTS (REEL/FRAME 045444/0299) Recorded Oct 26, 2022
From: BARCLAYS BANK PLC
To: BAUSCH & LOMB INCORPORATED; TECHNOLAS PERFECT VISION GMBH; THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES; PF CONSUMER HEALTHCARE 1 LLC; LABORATOIRE CHAUVIN S.A.S.
Reel/Frame 061779/0001 →
SECURITY INTEREST Recorded Feb 26, 2018
From: ATON PHARMA, INC.; BAUSCH & LOMB INCORPORATED; BAUSCH & LOMB PHARMA HOLDINGS CORP.; COMMONWEALTH LABORATORIES, LLC; DOW PHARMACEUTICAL SCIENCES, INC.; ECR PHARMACEUTICALS CO., INC.; LABORATOIRE CHAUVIN S.A.S.; MEDICIS PHARMACEUTICAL CORPORATION; ONPHARMA INC.; ORAPHARMA, INC.; PRECISION DERMATOLOGY, INC.; SALIX PHARMACEUTICALS, LTD.; SALIX PHARMACEUTICALS, INC.; SANTARUS, INC.; SOLTA MEDICAL, INC.; SYNERGETICS USA, INC.; TECHNOLAS PERFECT VISION GMBH; VALEANT CANADA LP; VALEANT PHARMACEUTICALS INTERNATIONAL; VALEANT PHARMACEUTICALS INTERNATIONAL, INC.; VALEANT PHARMACEUTICALS NORTH AMERICA LLC; WIRRA IP PTY LIMITED; VALEANT PHARMA POLAND SP. Z O.O.; VALEANT PHARMACEUTICALS LUXEMBOURG S.A R.L.; VALEANT PHARMACEUTICALS IRELAND LIMITED
To: BARCLAYS BANK PLC, AS COLLATERAL AGENT
Reel/Frame 045444/0299 →
SECURITY INTEREST Recorded Feb 26, 2018
From: ATON PHARMA, INC.; BAUSCH & LOMB INCORPORATED; BAUSCH & LOMB PHARMA HOLDINGS CORP.; COMMONWEALTH LABORATORIES, LLC; DOW PHARMACEUTICAL SCIENCES, INC.; ECR PHARMACEUTICALS CO., INC.; LABORATOIRE CHAUVIN S.A.S.; MEDICIS PHARMACEUTICAL CORPORATION; ONPHARMA INC.; ORAPHARMA, INC.; PRECISION DERMATOLOGY, INC.; SALIX PHARMACEUTICALS, LTD.; SALIX PHARMACEUTICALS, INC.; SANTARUS, INC.; SOLTA MEDICAL, INC.; SYNERGETICS USA, INC.; TECHNOLAS PERFECT VISION GMBH; VALEANT CANADA LP; VALEANT PHARMACEUTICALS INTERNATIONAL; VALEANT PHARMACEUTICALS INTERNATIONAL, INC.; VALEANT PHARMACEUTICALS NORTH AMERICA LLC; WIRRA IP PTY LIMITED; VALEANT PHARMA POLAND SP. Z O.O.; VALEANT PHARMACEUTICALS LUXEMBOURG S.A R.L.; VALEANT PHARMACEUTICALS IRELAND LIMITED
To: THE BANK OF NEW YORK MELLON, AS COLLATERAL AGENT
Reel/Frame 045444/0634 →
SECURITY INTEREST Recorded Jul 19, 2017
From: BAUSCH & LOMB INCORPORATED
To: THE BANK OF NEW YORK MELLON
Reel/Frame 043251/0932 →
NOTICE OF SUCCESSION OF AGENCY Recorded Jan 9, 2015
From: GOLDMAN SACHS LENDING PARTNERS, LLC
To: BARCLAYS BANK PLC, AS SUCCESSOR AGENT
Reel/Frame 034749/0689 →
SECURITY AGREEMENT Recorded Sep 4, 2013
From: BAUSCH & LOMB INCORPORATED
To: GOLDMAN SACHS LENDING PARTNERS LLC, AS COLLATERAL AGENT
Reel/Frame 031156/0508 →
RELEASE OF SECURITY INTEREST Recorded Aug 13, 2013
From: CITIBANK N.A., AS ADMINISTRATIVE AGENT
To: WP PRISM INC. (N/K/A BAUSCH & LOMB HOLDINGS INC.); BAUSCH & LOMB INCORPORATED; ISTA PHARMACEUTICALS
Reel/Frame 030995/0444 →
SECURITY AGREEMENT Recorded Aug 6, 2012
From: BAUSCH & LOMB INCORPORATED; EYEONICS, INC.
To: CITIBANK N.A., AS ADMINISTRATIVE AGENT
Reel/Frame 028728/0645 →
RELEASE OF SECURITY INTEREST Recorded Aug 5, 2012
From: CREDIT SUISSE AG, CAYMAN ISLANDS BRANCH
To: BAUSCH & LOMB INCORPORATED
Reel/Frame 028726/0142 →
SECURITY AGREEMENT Recorded Mar 26, 2008
From: BAUSCH & LOMB INCORPORATED; WP PRISM INC.; B&L CRL INC.; B&L CRL PARTNERS L.P.; B & L DOMESTIC HOLDINGS CORP.; B&L FINANCIAL HOLDINGS CORP.; B&L SPAF INC.; B&L VPLEX HOLDINGS, INC.; BAUSCH & LOMB CHINA, INC.; BAUSCH & LOMB INTERNATIONAL INC.; BAUSCH & LOMB REALTY CORPORATION; BAUSCH & LOMB SOUTH ASIA, INC.; BAUSCH & LOMB TECHNOLOGY CORPORATION; IOLAB CORPORATION; RHC HOLDINGS, INC.; SIGHT SAVERS, INC.; WILMINGTON MANAGEMENT CORP.; WILMINGTON PARTNERS L.P.; B&L MINORITY DUTCH HOLDINGS LLC
To: CREDIT SUISSE
Reel/Frame 020733/0765 →
SECURITY AGREEMENT Recorded Nov 16, 2007
From: BAUSCH & LOMB INCORPORATED; B&L CRL INC.; B&L CRL PARTNERS L.P.; B & L DOMESTIC HOLDINGS CORP.; B&L FINANCIAL HOLDINGS CORP.; B&L SPAF INC.; B&L VPLEX HOLDINGS, INC.; BAUSCH & LOMB CHINA, INC.; BAUSCH & LOMB INTERNATIONAL INC.; BAUSCH & LOMB TECHNOLOGY CORPORATION; BAUSCH & LOMB REALTY CORPORATION; BAUSCH & LOMB SOUTH ASIA, INC.; SIGHT SAVERS, INC.; WILMINGTON MANAGEMENT CORP.; WILMINGTON PARTNERS L.P.; B&L MINORITY DUTCH HOLDINGS LLC; IOLAB CORPORATION; RHC HOLDINGS, INC.; WP PRISM, INC.
To: CREDIT SUISSE
Reel/Frame 020122/0722 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 26, 2007
From: TECHNOVISION GMBH GESELLSCHAFT FUR DIE ENTWICKLUNG MEDIZINISCHER TECHNOLOGIE I.L.
To: BAUSCH & LOMB INCORPORATED
Reel/Frame 019878/0358 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 15, 2004
From: POLLAND, HANS JOACHIM
To: TECHNO VISION GMBH
Reel/Frame 015981/0832 →