2-heteroarylcarboxylic acid amides

1. A compound of the formula (I):

in which

R 1 represents 1-azabicyclo[2.2.2]oct-3-yl,

R 2 represents hydrogen or C 1 -C 6 -alkyl,

R 3 represents hydrogen, halogen or C 1 -C 6 -alkyl,

A represents oxygen or sulfur, and

the ring B represents benzo, pyrimido, pyrimidazo or pyridazino which is substituted by a radical selected from the group consisting of halogen, C 1 -C 6 -alkanoyl, carbamoyl, cyano, trifluoromethyl, trifluoromethoxy, nitro, amino, C 1 -C 6 -acylamino, C 1 -C 6 -alkyl, C 1 -C 6 -alkyoxy, C 1 -C 6 -alkylthio, C 1 -C 6 -alkylamino, heteroarylcarbonylamino, arylcarbonylamino, C 1 -C 6 -alkylsulfonyl-amino, di(C 1 -C 4 -alkylsulfonyl)amino, arylsulfonylamino, di(arylsulfonyl)amino, C 3 -C 6 -cycloalkylcarbonylmethyl, 1,3-dioxa-propane-1,3-diyl, amino(hydroxyimino)methyl and benzo,

or a salt, a hydrate or a hydrate of a salt thereof.

2. A compound of the formula (I) as claimed in claim 1 , in which

R 1 represents 1-azabicyclo[2.2.2]oct-3-yl,

R 2 represents hydrogen or C 1 -C 6 -alkyl,

R 3 represents hydrogen, halogen or C 1 -C 6 -alkyl,

A represents oxygen or sulfur, and

the ring B represents benzo, pyrimido, pyridazo or pyridazino which is substituted by a radical selected from the group consisting of halogen, formyl, carbamoyl, cyano, trifluoromethyl, trifluoromethoxy, nitro, amino, formamido, acetamido, (C 1 -C 6 -alkyl, (C 1 -C 6 )-alkoxy, (C 1 -C 6 )-alkylthio and benzo,

or a salt, a hydrate or a hydrate of a salt thereof.

3. A compound of the formula (I) as claimed in claim 1 , in which

R 1 represents 1-azabicyclo[2.2.2]oct-3-yl,

R 2 represents hydrogen,

R 3 represents hydrogen, chlorine, fluorine or methyl,

A represents oxygen or sulfur, and

the ring B represents benzo which is substituted by 1 to 3 radicals selected from the group consisting of halogen, formyl, carbamoyl, cyano, trifluoromethyl, trifluoromethoxy, nitro, amino, formamido, acetamido, C1-C4-alkyl, C1-C4-alkoxy, C1-C4-alkylthio, C1-C4-alkylamino, furylcarbonylamino, phenylcarbonylamino, methylsulfonylamino, di(phenylsulfonyl)amino, cyclopropylcarbonylmethyl, 1,3-dioxapropane-1,3-diyl, amino(hydroxyiminio)methyl and benzo,

or a salt, a hydrate or a hydrate of a salt thereof.

4. A compound as claimed in claim 1 of the formula (I), where

R 1 represents (3R)-1-azabicyclo[2.2.2]oct-3-yl, and

R 2 , R 3 , A and the ring B are as defined in claim 1 .

5. A compound as claimed in claim 1 of the formula (I), where

R 1 represents (3R)-1-azabicyclo[2.2.2]oct-3-yl, and

R 2 , and R 3 represent hydrogen,

A represents sulfur, and

the ring B represents benzo which is substituted by 1 to 3 radicals selected from the group consisting of halogen, cyano, trifluoromethyl, trifluoromethoxy, nitro, amino, formamido, acetamido and C 1 -C 4 -alkyl,

or a salt, a hydrate or a hydrate of a salt thereof.

6. A compound of the formula Ia:

in which

R 1 represents 1-azabicyclo[2.2.2]oct-3-yl,

R 2 represents hydrogen or C 1 -C 6 -alkyl,

R 3 represents hydrogen, halogen or C 1 -C 6 -alkyl,

A represents oxygen or sulfur,

and

Z represents halogen, formyl, carbamoyl, cyano, trifluoromethyl, trifluoromethoxy, nitro, amino, formamido, acetamido, C1-C6-alkyl, C1-C6-alkyoxy, C1-C6-alkylthio, C1-C6-alkylamino, heteroaryl-carbonylamino, arylcarbonylamino, C1-C4-alkylsulfonylamino, di(arylsulfonyl)amino, C3-C6-cycloalkylcarbonylmethyl or amino(hydroxyimino)methyl,

or a salt, a hydrate or a hydrate of a salt thereof.

7. A compound as claimed in claim 6 of the formula (Ia), in which

R 1 represents 1-azabicyclo[2.2.2]oct-3-yl,

R 2 represents hydrogen,

R 3 represents hydrogen, chlorine, fluorine or methyl,

A represents oxygen or sulfur, and

Z represents halogen, formyl, carbamoyl, cyano, trifluoromethyl, trifluoromethoxy, nitro, amino, formamido, acetamido, methyl, ethyl, methoxy, ethoxy, C1-C4-alkylamino, furylcarbonylamino, phenylcarbonylamino, methylsulfonylamino, di(phenyldulfonyl)amino, cyclopropylcarbonylmethyl or amino(hydroxyimino)methyl,

or a salt, a hydrate or a hydrate of a salt thereof.

8. A compound as claimed in claim 6 of the formula (Ia), in which

R 1 represents (3R)-1-azabicyclo[2.2.2]oct-3-yl,

R 2 represents hydrogen,

R 3 represents hydrogen, chlorine, fluorine or methyl,

A represents oxygen or sulfur, and

Z represents halogen, formyl, carbamoyl, cyano, trifluoromethyl, trifluoromethoxy, nitro, amino, formamido, acetamido, methyl, ethyl, methoxy, ethoxy, C1-C 4 -alkylamino, furylcarbonylamino, phenylcarbonylamino, methylsulfonylamino, di(phenyldulfonyl)amino, cyclopropylcarbonylmethyl or amino(hydroxyimino)methyl,

or a salt, a hydrate or a hydrate of a salt thereof.

9. A pharmaceutical composition comprising at least one of the compounds as claimed in any of claims 6 - 8 in a mixture with at least one pharmaceutically acceptable, essentially nontoxic carrier or excipient.

10. The compound of claim 6 wherein A represents oxygen.

11. The compound of claim 7 wherein A represents oxygen.

12. The compound of claim 8 wherein A represents oxygen.

13. The compound of claim 6 wherein A represents sulfur.

14. The compound of claim 7 wherein A represents sulfur.

15. The compound of claim 8 wherein A represents sulfur.

16. The compound of any of claims 6 - 8 and 10 - 15 wherein Z is selected from the group consisting of: halogen, cyano, trifluoromethyl, trifluoromethoxy, methyl, ethyl, methoxy, and ethoxy.

17. N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]-7-fluoro-1-benzofuran-2-carboxamide or a salt thereof.

18. N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]-5-fluoro-1-benzothiophene-2-carboxamideor or a salt thereof.

19. N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]-5,7-difluoro-1-benzothiophene-2-carboxamide or a salt thereof.

20. N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]-5-fluoro-1-benzofuran-2-carboxamide or a salt thereof.

21. N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]-5-chloro-1-benzofuran-2-carboxamide or a salt thereof.

22. N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]-5,7-difluoro-1-benzofuran-2-carboxamide or a salt thereof.

23. N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]-7-fluoro-1-benzothiophene-2-carboxamide or a salt thereof.

24. N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]-7-chloro-1-benzothiophene-2-carboxamide or a salt thereof.

25. N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]-7-cyano-1-benzothiophene-2-carboxamide or a salt thereof.

26. N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]-7-trifluoromethyl-1-benzothiophene-2-carboxamide or a salt thereof.

27. A pharmaceutical composition comprising N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]-7-fluoro-1-benzofuran-2-carboxamide or a salt thereof and a pharmaceutically acceptable carrier.

28. A pharmaceutical composition comprising N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]-5-fluoro-1-benzothiophene-2-carboxamide or a salt thereof and a pharmaceutically acceptable carrier.

29. A pharmaceutical composition comprising N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]-5,7-difluoro-1-benzothiophene-2-carboxamide or a salt thereof and a pharmaceutically acceptable carrier.

30. A pharmaceutical composition comprising N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]-5-fluoro-1-benzofuran-2-carboxamide or a salt thereof and a pharmaceutically acceptable carrier.

31. A pharmaceutical composition comprising N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]-5-chloro-1-benzofuran-2-carboxamide or a salt thereof and a pharmaceutically acceptable carrier.

32. A pharmaceutical composition comprising N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]-5,7-difluoro-1-benzofuran-2-carboxamide or a salt thereof and a pharmaceutically acceptable carrier.

33. A pharmaceutical composition comprising N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]-7-fluoro-1-benzothiophene-2-carboxamide or a salt thereof and a pharmaceutically acceptable carrier.

34. A pharmaceutical composition comprising N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]-7-chloro-1-benzothiophene-2-carboxamide or a salt thereof and a pharmaceutically acceptable carrier.

35. A pharmaceutical composition comprising N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]-7-cyano-1-benzothiophene-2-carboxamide or a salt thereof and a pharmaceutically acceptable carrier.

36. A pharmaceutical composition comprising N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]-7-trifluoromethyl-1-benzothiophene-2-carboxamide or a salt thereof and a pharmaceutically acceptable carrier.

37. A hydrate of N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]-7-fluoro-1-benzofuran-2-carboxamide or a salt thereof.

38. A hydrate of N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]-5-fluoro-1-benzothiophene-2-carboxamide or a salt thereof.

39. A hydrate of N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]-5,7-difluoro-1-benzothiophene-2-carboxamide or a salt thereof.

40. A hydrate of N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]-5-fluoro-1-benzofuran-2-carboxamide or a salt thereof.

41. A hydrate of N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]-chloro-1-benzofuran-2-carboxamide or a salt thereof.

42. A hydrate of N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]-5,7-difluoro-1-benzofuran-2-carboxamide or a salt thereof.

43. A hydrate of N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]-7-fluoro-1-benzothiophene-2-carboxamide or a salt thereof.

44. A hydrate of N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]-7-chloro-1-benzothiophene-2-carboxamide or a salt thereof.

45. A hydrate of N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]-7-cyano-1-benzothiophene-2-carboxamide or a salt thereof.

46. A hydrate of N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]-7-trifluoromethyl-1-benzothiophene-2-carboxamide or a salt thereof.

47. A pharmaceutical composition comprising a hydrate of N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]-7-fluoro-1-benzofuran-2-carboxamide or a salt thereof and a pharmaceutically acceptable carrier.

48. A pharmaceutical composition comprising a hydrate of N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]-5-fluoro-1-benzothiophene-2-carboxamide or a salt thereof and a pharmaceutically acceptable carrier.

49. A pharmaceutical composition comprising a hydrate of N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]-5,7-difluoro-1-benzothiophene-2-carboxamide or a salt thereof and a pharmaceutically acceptable carrier.

50. A pharmaceutical composition comprising a hydrate of N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]-5-fluoro-1-benzofuran-2-carboxamide or a salt thereof and a pharmaceutically acceptable carrier.

51. A pharmaceutical composition comprising a hydrate of N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]-5-chloro-1-benzofuran-2-carboxamide or a salt thereof and a pharmaceutically acceptable carrier.

52. A pharmaceutical composition comprising a hydrate of N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]-5,7-difluoro-1-benzofuran-2-carboxamide or a salt thereof and a pharmaceutically acceptable carrier.

53. A pharmaceutical composition comprising a hydrate of N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]-7-fluoro-1-benzothiophene-2-carboxamide or a salt thereof and a pharmaceutically acceptable carrier.

54. A pharmaceutical composition comprising a hydrate of N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]-7-chloro-1-benzothiophene-2-carboxamide or a salt thereof and a pharmaceutically acceptable carrier.

55. A pharmaceutical composition comprising a hydrate of N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]-7-cyano-1-benzothiophene-2-carboxamide or a salt thereof and a pharmaceutically acceptable carrier.

56. A pharmaceutical composition comprising a hydrate of N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]-7-trifluoromethyl-1-benzothiophene-2-carboxamide or a salt thereof and a pharmaceutically acceptable carrier.