Crystalline tricyclic triazolobenzazepine derivative
View Patent ↗Disclosed are novel crystalline 2-(1-isopropoxycarbonyloxy-2-methylpropyl)-7,8-dimethoxy-4(5H),10-dioxo-2H-1,2,3-triazolo[4,5-c][1]benzazepine and a pharmaceutical composition comprising the same.
1. Crystalline compound of 2-(1-isopropoxycarbonyloxy-2-methylpropyl)-7,8-dimethoxy-4(5H)10-dioxo-2H-1,2,3-triazolo[4,5-c][1]benzazepine which has diffraction peaks at diffraction angles (2θ): 11.2±0.1°, 14.4±0.1°, 15.5±0.1°, and 25.3±0.1° in a powder X-ray diffraction pattern.
2. The crystalline compound according to claim 1 , which has a purity of not less than 99% as determined based on percentage area obtained by HPLC (high-performance liquid chromatography).
3. The crystalline compound according to claim 1 or 2 , which has a melting point in the temperature range of 240 to 246° C. (with decomposition) as determined from an endothermic peak in a DSC (differential scanning calorimetry) chart obtained by DSC.