IP Library › Granted Patent US 7,354,760
Granted Patent B2
US 7,354,760 · App. 10/500,351 · Granted Apr 8, 2008

Expression of protective antigens in transgenic chloroplasts

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Quick Facts
Patent No.
US 7,354,760
App. No.
10/500,351
Granted
Apr 8, 2008
Kind
B2
Abstract

Vectors and methods for plastid transformation of plants to produce protective antigens and vaccines for oral delivery are provided. The invention provides edible vaccines for conferring immunity to a mammal against Bacillus anthracis , as well as Yersina pestis.

Claims (2)

1. A plastid transformation vector for stably transforming a plastid, said plastid vector comprising, as operably linked components, a first flanking sequence, at least one regulatory sequence operable in a plastid, a DNA sequence coding for a protective antigen, a DNA sequence coding for a chaperonin, and a second flanking sequence.

2. A plastid transformation vector for stably transforming a plastid, said plastid vector comprising, as operably linked components, a first flanking sequence, at least one regulatory sequence operable in a plaslid, a DNA sequence coding for a protective antigen, a DNA sequence coding for a chaperonin, and a second flanking sequence, wherein said protective antigen is a bacterial antigen.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 23, 2015
From: UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC.
To: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
Reel/Frame 035226/0274 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 18, 2007
From: DANIELL, HENRY
To: UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC.
Reel/Frame 020263/0818 →