Topical ivermectin composition
View Patent ↗A topical gel composition comprising between about 0.005 and 1.0% ivermectin, between about 30 and 40% of a pharmaceutically acceptable alcohol, between about 30 and 40% of a pharmaceutically acceptable glycol, and a pharmaceutically acceptable carrier, useful for treating Pediculosis capitis infestation in a human patient.
1. A topical gel composition comprising between about 0.005 and 1.0% ivermectin, between about 30 and 40% of a pharmaceutically acceptable alcohol, between about 30 and 40% of a pharmaceutically acceptable glycol, and a pharmaceutically acceptable carrier.
2. A composition of claim 1 wherein the pharmaceutically acceptable glycol is propylene glycol and the pharmaceutically acceptable alcohol is ethyl alcohol.
3. A composition of claim 2 which additionally comprises between 4 and 8% of a pharmaceutically acceptable nonionic surfactant, between about 1 and 2.5% d-limonene, and between about 0.1 and 1% of a pharmaceutically acceptable viscosifying agent.
4. A composition of claim 3 wherein the viscosifying agent is hydroxypropylcellulose.
5. A composition of claim 4 comprising about 0.009 to 0.011% ivermectin, about 32 to 34% propylene glycol, about 32 to 34% ethyl alcohol, about 5 to 7% sorbitan mono-9-octadecenoate poly(oxy-1,2-ethanediyl derivative, about 1.7 to 1.8% d-limonene, about 0.4 to 0.6% hydroxypropylcellulose, and a pharmaceutically acceptable carrier.
6. A method for treating Pediculosis capitis infestation in a human patient which comprises topically administering to the human a composition of claim 1 .
7. A method for treating Pediculosis capitis infestation in a human patient which comprises topically administering to the human a composition of claim 1 on one day and orally administering an oral composition comprising ivermectin on a second day.