IP Library › Granted Patent US 7,375,134

Granted Patent B2

US 7,375,134 · App. 10/505,796 · Granted May 20, 2008

Cathepsin cysteine protease inhibitors

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Patent No.: US 7,375,134
App. No.: 10/505,796
Granted: May 20, 2008
Kind: B2

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Abstract

This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis.

Claims (131)

1. The present invention relates to compounds of the following chemical formula:

wherein R 1 is hydrogen, C 1-6 alkyl or C 2-6 alkenyl wherein said alkyl and alkenyl groups are optionally substituted with one to six halo, C 3-6 cycloalkyl, —SR 9 , —SR 12 , —SOR 9 , —SOR 12 , —SO 2 R 9 , —SO 2 R 12 , —SO 2 CH(R 12 )(R 11 ), —OR 12 , —OR 9 , or —N(R 12 ) 2 ;

R 2 is hydrogen, C 1-6 alkyl or C 2-6 alkenyl wherein said alkyl and alkenyl groups are optionally substituted with one to six halo, C 3-6 cycloalkyl, —SR 9 , —SR 12 , —SOR 9 , —SOR 12 , —SO 2 R 9 , —SO 2 R 12 , —SO 2 CH(R 12 )(R 11 ), —OR 12 , —OR 9 , or —N(R 12 ) 2 ;

or R 1 and R 2 can be taken together with the carbon atom to which they are attached to form a C 3-8 cycloalkyl or heterocyclyl ring wherein said ring system is optionally substituted with one or two substituents independently selected from C 1-6 alkyl, hydroxyalkyl, haloalkyl, or halo;

R 3 is hydrogen, C 1-6 alkyl or C 2-6 alkenyl wherein said alkyl and alkenyl groups are optionally substituted with C 3-6 cycloalkyl or one to six halo;

R 4 is hydrogen, C 1-6 alkyl or C 2-6 alkenyl wherein said alkyl and alkenyl groups are optionally substituted with C 3-6 cycloalkyl or one to six halo;

R 5 is hydrogen;

R 6 is C 1-6 haloalkyl;

D is biphenyl which is optionally substituted with one to five substituents independently selected from C 1-6 alkyl, halo, —SO 2 R 9 , or —SO 2 R 10 ;

R 7 is hydrogen;

R 8 is hydrogen or C 1-6 alkyl;

R 9 is selected from the group consisting of hydrogen, aryl, aryl(C 1-4 )alkyl, heteroaryl, heteroaryl(C 1-4 )alkyl, C 3-8 cycloalkyl, C 3-8 cycloalkyl(C 1-4 )alkyl, and heterocyclyl(C 1-4 )alkyl wherein said groups can be optionally substituted with one, two, or three substituents independently selected from halo, alkoxy or —SO 2 R 12 ;

R 10 is hydrogen or C 1-6 alkyl

R 11 is hydrogen or C 1-6 alkyl;

R 12 is hydrogen or C 1-6 alkyl which is optionally substituted with one, two, or three substituents independently selected from halo, alkoxy, cyano, —NR 10 or —SR 10 ;

n is one;

and the pharmaceutically acceptable salts, stereoisomers and N-oxide derivatives thereof.

2. The compound of claim 1 wherein R 1 is hydrogen and R 2 is hydrogen, or R 1 and R 2 can be taken together with the carbon atom to which they are attached to form a C 3-8 cycloalkyl ring wherein said ring system is optionally substituted with one or two substituents selected from C 1-6 alkyl or halo, and the pharmaceutically acceptable salts, stereoisomers and N-oxide derivatives thereof.

3. The compound of claim 2 wherein R 3 is C 1-6 alkyl which is optionally substituted with one to six halo and R 4 is hydrogen, and the pharmaceutically acceptable salts, stereoisomers and N-oxide derivatives thereof.

4. The compound of claim 3 wherein R 3 is n-propyl, isobutyl, 2-fluoro-2-methylpropyl, 2-trifluoromethylpropyl, 3-fluoro-2-(2-fluoromethyl)propyl, 2,2-difluoroethyl, 2,2-difluoropropyl, 3,3,3-trifluoropropyl, or 2,2-dichloroethyl and R 4 is hydrogen; and the pharmaceutically acceptable salts, stereoisomers and N-oxide derivatives thereof.

5. The compound of claim 4 wherein R 5 is hydrogen and R 6 is trifluoromethyl or 3,3,3,2,2-pentafluoroethyl; and the pharmaceutically acceptable salts, stereoisomers and N-oxide derivatives thereof.

6. The compound of claim 1 selected from:

N 1 -(1-cyanocyclopropyl)-4-fluoro-N 2 -{(1S)-2,2,2-trifluoro-1-[4′-(methylsulfonyl)-1,1′-biphenyl-4-yl]ethyl}-L-leucinamide;

N 1 -(cyanomethyl)-N 2 -[(1S)-2,2,2-trifluoro-1-(4′-fluoro-1,1′-biphenyl-4-yl)ethyl]-L-leucinamide;

N 1 -(cyanomethyl)-N 2 -{(1S)-2,2,3,3,3-pentafluoro-1-[4′-(methylsulfonyl)-1,1′-biphenyl-4-yl]propyl}-L-leucinamide;

N 1 -(cyanomethyl)-N 2 -[(1S)-2,2,2-trifluoro-1-(2′-fluoro-1,1′-biphenyl-4-yl)ethyl]-L-leucinamide;

N 1 -(cyanomethyl)-N 2 -[(1S)-1-(3′,4′-difluoro-1,1′-biphenyl-4-yl)-2,2,2-trifluoroethyl]-L-leucinamide;

N 1 -(cyanomethyl)-N 2 -{(1S)-2,2,2-trifluoro-1-[2′-(trifluoromethyl)-1,1′-biphenyl-4-yl]ethyl}-L-leucinamide;

N 1 -(cyanomethyl)-N 2 -[(1S)-1-(3′,4′-dichloro-1,1′-biphenyl-4-yl)-2,2,2-trifluoroethyl]-L-leucinamide;

N 2 -{(1S)-1-[4′-(acetylamino)-3′-fluoro-1,1′-biphenyl-4-yl]-2,2,2-trifluoroethyl}-N 1 -(cyanomethyl)-L-leucinamide;

N 1 -(cyanomethyl)-N 2 -[(1S)-2,2,2-trifluoro-1-(3′-fluoro-1,1′-biphenyl-4-yl)ethyl]-L-leucinamide;

N 1 -(cyanomethyl)-N 2 -[(1S)-1-(3′,5′-difluoro-1,1′-biphenyl-4-yl)-2,2,2-trifluoroethyl]-L-leucinamide;

N 1 -(cyanomethyl)-N 2 -[(1S)-2,2,2-trifluoro-1-(2′,3′,5′-trifluoro-1,1′-biphenyl-4-yl)ethyl]-L-leucinamide;

N 1 -(cyanomethyl)-N 2 -{2,2,2-trifluoro-1-[4′-(methylsulfonyl)-1,1′-biphenyl-4-yl]ethyl}-L-leucinamide;

N 1 -(cyanomethyl)-N 2 -{(1S)-2,2,2-trifluoro-1-[4′-(methylsulfonyl)-1,1′-biphenyl-4-yl]ethyl}-L-leucinamide;

N 1 -(cyanomethyl)-N 2 -{(1R)-2,2,2-trifluoro-1-[4′-(methylsulfonyl)-1,1′-biphenyl-4-yl]ethyl}-L-leucinamide;

N 1 -(cyanomethyl)-N 2 -{(1S)-2,2,2-trifluoro-1-[4′-(isopropylsulfonyl)-1,1′-biphenyl-4-yl]ethyl}-L-leucinamide;

N 1 -(cyanomethyl)-N 2 -{(1S)-2,2,2-trifluoro-1-[2′-methyl-4′-(methylsulfonyl)-1,1′-biphenyl-4-yl]ethyl}-L-leucinamide;

N 1 -(cyanomethyl)-N 2 -{2,2,2-trifluoro-1-[4′-(methylsulfonyl)-1,1′-biphenyl-3-yl]ethyl}-L-leucinamide;

N 2 -[(1S)-1-(4′-bromo-1,1′-biphenyl-4-yl)-2,2,2-trifluoroethyl]-N 1 -(cyanomethyl)-L-leucinamide;

N 2 -[(1S)-1-(1,1′-biphenyl-4-yl)-2,2,2-trifluoroethyl]-N 1 -(cyanomethyl)-L-leucinamide;

N 1 -(cyanomethyl)-3-(1-methylcyclopropyl)-N 2 -{(1S)-2,2,2-trifluoro-1-[4′-(methylsulfonyl)-1,1′-biphenyl-4-yl]ethyl}-L-alaninamide;

N 1 -(cyanomethyl)-N 2 -[(1S)-2,2,2-trifluoro-1-(4′-methyl-1,1′-biphenyl-4-yl)ethyl]-L-leucinamide;

N 1 -(cyanomethyl)-N 2 -{2,2,2-trifluoro-1-[4′-(methylsulfonyl)-1,1′-biphenyl-4-yl]ethyl}-D-leucinamide;

N 1 -(cyanomethyl)-N 2 -[(1S)-2,2,2-trifluoro-1-(2′-fluoro-1,1′-biphenyl-4-yl)ethyl]-L-leucinamide;

N 1 -(cyanomethyl)-N 2 -{2,2,2-trifluoro-1-[3′-(methylsulfonyl)-1,1′-biphenyl-4-yl]ethyl}-L-leucinamide;

N 2 -{(1S)-1-[4′-bromo-3′-(methylsulfonyl)-1,1′-biphenyl-4-yl]-2,2,2-trifluoroethyl}-N 1 -(cyanomethyl)-L-leucinamide;

N 1 -(cyanomethyl)-N 2 -((1S)-2,2,2-trifluoro-1-{4′-[(trifluoromethyl)sulfonyl]-1,1′-biphenyl-4-yl}ethyl)-L-leucinamide;

N 1 -(1-cyanocyclopropyl)-N 2 -{(1S)-2,2,2-trifluoro-1-[4′-(methylsulfonyl)-1,1′-biphenyl-4-yl]ethyl}-L-leucinamide;

N 1 -(cyanomethyl)-N 2 -{(1S)-1-[4′-(ethylsulfonyl)-1,1′-biphenyl-4-yl]-2,2,2-trifluoroethyl}-L-leucinamide;

N 2 -{(1S)-1-[2′-chloro-4′-(methylsulfonyl)-1,1′-biphenyl-4-yl]-2,2,2-trifluoroethyl}-N 1 -(cyanomethyl)-L-leucinamide;

N 1 -(cyanomethyl)-N 2 -{(1S)-2,2,2-trifluoro-1-[3′-fluoro-4′-(methylsulfonyl)-1,1′-biphenyl-4-yl]ethyl}-L-leucinamide;

N 1 -(cyanomethyl)-N 2 -{(1S)-2,2,2-trifluoro-1-[3′-(methylsulfonyl)-1,1′-biphenyl-4-yl]ethyl}-L-leucinamide;

N 1 -(1-cyanocyclopropyl)-N 2 -[(1S)-2,2,2-trifluoro-1-(3′-fluoro-4′-methyl-1,1′-biphenyl-4-yl)ethyl]-L-leucinamide;

N 1 -(1-cyanocyclopropyl)-N 2 -[(1S)-2,2,3,3,3-pentafluoro-1-(4′-methyl-1,1′-biphenyl-4-yl)propyl]-L-leucinamide;

N 1 -(cyanomethyl)-N 2 -[(1S)-2,2,3,3,3-pentafluoro-1-(2′-fluoro-1,1′-biphenyl-4-yl)propyl]-L-leucinamide;

N 1 -(cyanomethyl)-4-fluoro-N 2 -{(1S)-2,2,2-trifluoro-1-[4′-(methylsulfonyl)-1,1′-biphenyl-4-yl]ethyl}-L-leucinamide;

N 1 -(1-cyanocyclopropyl)-4-fluoro-N 2 -{(1S)-2,2,2-trifluoro-1-[2′-methyl-4′-(methylsulfonyl)-1,1′-biphenyl-4-yl]ethyl}-L-leucinamide;

N 1 -(1-cyanocyclopropyl)-N 2 -{(1S)-2,2-difluoro-1-[4′-(methylsulfonyl)-1,1′-biphenyl-4-yl]ethyl}-L-leucinamide;

N 2 -[(1S)-1-(1,1′-biphenyl-4-yl)-2,2,2-trifluoroethyl]-N 1 -(1-cyanocyclopropyl)-L-leucinamide;

N 1 -(1-cyanocyclopropyl)-N 2 -[(1S)-2,2,2-trifluoro-1-(2′,4′,6′-trimethyl-1,1′-biphenyl-4-yl)ethyl]-L-leucinamide;

N 2 -[(1S)-1-(1,1′-biphenyl-4-yl)-2,2,3,3,3-pentafluoropropyl]-N 1 -(cyanomethyl)-L-leucinamide;

N 2 -[(1S)-1-(1,1′-biphenyl-4-yl)-2,2,3,3,3-pentafluoropropyl]-N 1 -(1-cyanocyclopropyl)-L-leucinamide;

N 1 -[(1S)-1-cyanoethyl]-N 2 -{(1S)-2,2,2-trifluoro-1-[4′-(methylsulfonyl)-1,1′-biphenyl-4-yl]ethyl}-L-leucinamide;

N 1 -[(1S)-1-cyano-3-(methylthio)propyl]-N 2 -{(1S)-2,2,2-trifluoro-1-[4′-(methylsulfonyl)-1,1′-biphenyl-4-yl]ethyl}-L-leucinamide;

N 1 -[(1S)-1-cyano-3-(methylsulfonyl)propyl]-N 2 -{(1S)-2,2,2-trifluoro-1-[4′-(methylsulfonyl)-1,1′-biphenyl-4-yl]ethyl}-L-leucinamide;

(4S)-N 1 -(cyanomethyl)-5,5,5-trifluoro-N 2 -{(1S)-2,2,2-trifluoro-1-[4′-(methylsulfonyl)-1,1′-biphenyl-4-yl]ethyl}-L-leucinamide;

(4S)-N 1 -(1-cyanocyclopropyl)-5,5,5-trifluoro-N 2 -{(1S)-2,2,2-trifluoro-1-[4′-(methylsulfonyl)-1,1′-biphenyl-4-yl]ethyl}-L-leucinamide;

N 1 -(1-cyanocyclopropyl)-N 2 -{(1S)-2,2,3,3,3-pentafluoro-1-[4′-(methylsulfonyl)-1,1′-biphenyl-4-yl]propyl}-L-leucinamide;

(4R)-N 1 -(cyanomethyl)-5,5,5-trifluoro-N 2 -{(1S)-2,2,2-trifluoro-1-[4′-(methylsulfonyl)-1,1′-biphenyl-4-yl]ethyl}-L-leucinamide;

(4R)-N 1 -(1-cyanocyclopropyl)-5,5,5-trifluoro-N 2 -{(1S)-2,2,2-trifluoro-1-[4′-(methylsulfonyl)-1,1′-biphenyl-4-yl]ethyl}-L-leucinamide;

N 1 -(cyanomethyl)-N 2 -[(1S)-2,2,3,3,3-pentafluoro-1-(4′-methyl-1,1′-biphenyl-4-yl)propyl]-L-leucinamide;

N 1 -(1-cyanocyclopropyl)-N 2 -{(1S)-1-[4′-(ethylsulfonyl)-1,1′-biphenyl-4-yl]-2,2,2-trifluoroethyl}-4-fluoro-L-leucinamide;

N 1 -(cyanomethyl)-N 2 -{(1S)-2,2,2-trifluoro-1-[4′-(methylsulfonyl)-1,1′-biphenyl-4-yl]ethyl}-L-alaninamide;

N 1 -(cyanomethyl)-N 2 -{(1S)-2,2,3,3,3-pentafluoro-1-[4′-(isopropylsulfonyl)-1,1′-biphenyl-4-yl]propyl}-L-leucinamide;

N 1 -(1-cyano-1-methylethyl)-N 2 -{(1S)-2,2,2-trifluoro-1-[4′-(methylsulfonyl)-1,1′-biphenyl-4-yl]ethyl}-L-leucinamide;

N 1 -(1-cyanocyclopropyl)-N 2 -{(1S)-2,2,2-trifluoro-1-[2′-methyl-4′-(methylsulfonyl)-1,1′-biphenyl-4-yl]ethyl}-L-leucinamide;

N 1 -(1-cyanocyclopropyl)-N 2 -{(1S)-1-[4′-(ethylsulfonyl)-1,1′-biphenyl-4-yl]-2,2,2-trifluoroethyl}-L-leucinamide;

N 1 -(cyanomethyl)-N 2 -{2,2,2-trifluoro-1-[4′-(methylsulfonyl)-1,1′-biphenyl-4-yl]ethyl}-L-norvalinamide;

N 1 -(cyanomethyl)-5,5,5-trifluoro-N 2 -{(1S)-2,2,2-trifluoro-1-[4′-(methylsulfonyl)-1,1′-biphenyl-4-yl]ethyl}-L-norvalinamide;

N 1 -(1-cyanocyclopropyl)-N 2 -{(1S)-2,2,2-trifluoro-1-[4′-(methylsulfonyl)-1,1′-biphenyl-4-yl]ethyl}-L-norvalinamide;

N 1 -(1-cyanocyclopropyl)-5,5,5-trifluoro-N 2 -{(1S)-2,2,2-trifluoro-1-[4′-(methylsulfonyl)-1,1′-biphenyl-4-yl]ethyl}-L-norvalinamide;

(2S)-2-[(S)-1-(2′,4′-Difluorobiphenyl-4-yl)-2,2,2-trifluoroethylamino]-pentanoic acid (1-cyanocyclopropyl)-amide;

(2S)-2-[(S)-1-(3′,4′-Difluorobiphenyl-4-yl)-2,2,2-trifluoroethylamino]-pentanoic acid (1-cyanocyclopropyl)-amide;

(2S)-2-[(S)-1-(3′-Chloro-4′-fluorobiphenyl-4-yl)-2,2,2-trifluoroethylamino]-pentanoic acid (1-cyano-cyclopropyl)-amide;

N 1 -(1-cyanocyclopropyl)-N 2 -{(1S)-2,2,2-trifluoro-1-[4′-chloro-1,1′-biphenyl-4-yl]ethyl}-L-norvalinamide;

N 1 -(1-cyanocyclopropyl)-N 2 -{(1S)-2,2,2-trifluoro-1-[4′-chloro-3′-methyl-1,1′-biphenyl-4-yl]ethyl}-L-norvalinamide;

N 1 -(1-cyanocyclopropyl)-N 2 -{(1S)-2,2,2-trifluoro-1-[4′-chloro-2′-methyl-1,1′-biphenyl-4-yl]ethyl}-L-norvalinamide;

N 1 -(1-cyanocyclopropyl)-N 2 -{(1S)-2,2,2-trifluoro-1-[4′-fluoro-1,1′-biphenyl-4-yl]ethyl}-L-norvalinamide;

N 1 -(1-cyanocyclopropyl)-N 2 -{(1S)-2,2,2-trifluoro-1-[4′-fluoro-3′-methyl-1,1′-biphenyl-4-yl]ethyl}-L-norvalinamide;

N 1 -(1-cyanocyclopropyl)-N 2 -{(1S)-2,2,2-trifluoro-1-[3′-fluoro-4′-methyl-1,1′-biphenyl-4-yl]ethyl}-L-norvalinamide;

(2S)-2-[(S)-2,2,2-Trifluoro-1-(4′-methylbiphenyl-4-yl)-ethylamino]-pentanoic acid (1-cyanocyclopropyl)-amide;

N 1 -(1-cyanocyclopropyl)-4,4-difluoro-N 2 -{(1S)-2,2,2-trifluoro-1-[4′-(methylsulfonyl)-1,1′-biphenyl-4-yl]ethyl}-L-norvalinamide;

N 1 -(cyanomethyl)-4,4-difluoro-N 2 -{(1S)-2,2,2-trifluoro-1-[4′-(methylsulfonyl)-1,1′-biphenyl-4-yl]ethyl}-L-norvalinamide;

N 1 -(cyanomethyl)-4-fluoro-N 2 -{(1S)-2,2,2-trichloro-1-[4′-(methylsulfonyl)-1,1′-biphenyl-4-yl]ethyl}-L-leucinamide;

N 1 -(1-cyanocyclopropyl)-4-fluoro-N 2 -{(1S)-2,2,2-trichloro-1-[4′-(methylsulfonyl)-1,1′-biphenyl-4-yl]ethyl}-L-leucinamide;

N 1 -(1-cyanocyclopropyl)-4,4-difluoro-N 2 -{(1S)-2,2,2-trichloro-1-[4′-(methylsulfonyl)-1,1′-biphenyl-4-yl]ethyl}-L-norvalinamide;

N 1 -(cyanomethyl)-4,4-difluoro-N 2 -{(1S)-2,2,2-trichloro-1-[4′-(methylsulfonyl)-1,1′-biphenyl-4-yl]ethyl}-L-norvalinamide;

(2S)-N-(cyanomethyl)-4,4-difluoro-2-({(1S)-2,2,2-trifluoro-1-[4′-(methylsulfonyl)-1,1′-biphenyl-4-yl]ethyl}amino)butanamide;

(2S)-N-(1-cyanocyclopropyl)-4,4-difluoro-2-({(1S)-2,2,2-trifluoro-1-[4′-(methylsulfonyl)-1,1′-biphenyl-4-yl]ethyl}amino)butanamide;

(2S)-N-(1-cyanocyclopropyl)-4,4-difluoro-2-({(1S)-2,2,2-trichloro-1-[4′-(methylsulfonyl)-1,1′-biphenyl-4-yl]ethyl}amino)butanamide;

(2S)-N-(cyanomethyl)-4,4-difluoro-2-({(1S)-2,2,2-trichloro-1-[4′-(methylsulfonyl)-1,1′-biphenyl-4-yl]ethyl}amino)butanamide;

(2S)-4,4-dichloro-N-(cyanomethyl)-2-({(1S)-2,2,2-trifluoro-1-[4′-(methylsulfonyl)-1,1′-biphenyl-4-yl]ethyl}amino)butanamide;

(2S)-4,4-dichloro-N-(1-cyanocyclopropyl)-2-({(1S)-2,2,2-trifluoro-1-[4′-(methylsulfonyl)-1,1′-biphenyl-4-yl]ethyl}amino)butanamide;

(2S)-4,4-dichloro-N-(1-cyanocyclopropyl)-2-({(1S)-2,2,2-trichloro-1-[4′-(methylsulfonyl)-1,1′-biphenyl-4-yl]ethyl}amino)butanamide;

(2S)-4,4dichloro-N-(cyanomethyl)-2-({(1S)-2,2,2-trichloro-1-[4′-(methylsulfonyl)-1,1′-biphenyl-4-yl]ethyl}amino)butanamide;

N 2 -[(1S)-1-(1,1′-biphenyl-4-yl)-2,2,2-trifluoroethyl]-N 1 -(1-cyanocyclopropyl)-4-fluoro-L-leucinamide;

N 1 -(1-cyanocyclopropyl)-4-fluoro-N 2 -[(1S)-2,2,2-trifluoro-1-(4′-methyl-1,1′-biphenyl-4-yl)ethyl]-L-leucinamide;

N 1 -(1-cyanobutyl)-4-fluoro-N 2 -{(1S)-2,2,2-trifluoro-1-[4′-(methylsulfonyl)-1,1′-biphenyl-4-yl]ethyl}-L-leucinamide;

N 1 -(1-cyano-2-cyclopropylethyl)-4-fluoro-N 2 -{(1S)-2,2,2-trifluoro-1-[4′-(methylsulfonyl)-1,1′-biphenyl-4-yl]ethyl}-L-leucinamide;

N 1 -(1-cyano-3-hydroxy-3-methylbutyl)-4-fluoro-N 2 -{(1S)-2,2,2-trifluoro-1-[4′-(methylsulfonyl)-1,1′-biphenyl-4-yl]ethyl}-L-leucinamide;

N 1 -(1-cyanocyclopropyl)-4,4-difluoro-N 2 -{(1S)-2,2,2-trifluoro-1-[4′-(methylsulfonyl)-1,1′-biphenyl-4-yl]ethyl}-L-norvalinamide;

N 1 -[(1S)-1-cyano-3-(methylsulfonyl)propyl]-N 2 -{(1S)-2,2,2-trifluoro-1-[4′-(methylsulfonyl)-1,1′-biphenyl-4-yl]ethyl}-L-leucinamide;

N 1 -(1-cyanocyclopropyl)-4,4-difluoro-N 2 -{(1S)-2,2,2-trifluoro-1-[4′-(methylsulfonyl)-1,1′-biphenyl-4-yl]ethyl}-L-norvalinamide;

N 1 -(1-cyanocyclopropyl)-4-fluoro-N 2 -[(1S)-2,2,2-trifluoro-1-(4′-fluoro-1,1′-biphenyl-4-yl)ethyl]-L-leucinamide;

N 1 -(1-cyanocyclopropyl)-4-fluoro-N 2 -{(1S)-2,2,2-trifluoro-1-[3′-methyl-4′-(methylsulfonyl)-1,1′-biphenyl-4-yl]ethyl}-L-leucinamide;

N 1 -(cyanomethyl)-4,4-difluoro-N 2 -{(1S)-2,2,2-trifluoro-1-[4′-(methylsulfonyl)-1,1′-biphenyl-4-yl]ethyl}-L-norvalinamide;

N 1 -(1-cyanocyclopropyl)-4-fluoro-N 2 -[(1S)-2,2,2-trifluoro-1-(4′-methyl-1,1′-biphenyl-4-ylethyl]-L-leucinamide;