Medicament for treating lung cancer
View Patent ↗By using a combination of amrubicin or a pharmaceutically acceptable salt thereof with another medicament for treating lung cancer (irinotecan, vinorelbine, gemcitabine, etc.), it is intended to provide medicaments for treating lung cancer having an improved antitumor therapeutic effect on lung cancer and reduced side effects. Lung cancer can be effectively treated using these medicaments.
1. A method for treating a lung cancer which comprises administering to a patient in need thereof an effective amount of amrubicin or a pharmaceutically acceptable salt thereof and a second medicament for treating lung cancer, said second medicament being selected from the group consisting of irinotecan, vinorelbine and gemcitabine.
2. The method for treating lung cancer as described in claim 1 , wherein the lung cancer is small cell lung cancer, lung adenocarcinoma, squamous cell lung carcinoma or large cell lung carcinoma.
3. The method for treating lung cancer as described in claim 1 , wherein the lung cancer is small cell lung cancer or squamous cell lung carcinoma.
4. The method for treating lung cancer as described in claim 1 , wherein the amrubicin or a pharmaceutically acceptable salt thereof is amrubicin hydrochloride.
5. The method for treating lung cancer as described in claim 1 , wherein the second medicament for treating lung cancer is irinotecan.
6. The method for treating lung cancer as described in claim 1 , wherein amrubicin or a pharmaceutically acceptable salt thereof is administered simultaneously with, or sequentially with the other medicament for treating lung cancer.
7. The method for treating lung cancer as described in claim 1 , wherein about 60 to about 150 mg/m 2 of amrubicin or a pharmaceutically acceptable salt thereof is administered in a single dose or in 2 to 5 divided doses.
8. The method for treating lung cancer as described in claim 7 , wherein about 80 to about 130 mg/m 2 of amrubicin or a pharmaceutically acceptable salt thereof is administered in a single dose.
9. The method for treating lung cancer as described in claim 7 , wherein about 110 to about 130 mg/m 2 of amrubicin or a pharmaceutically acceptable salt thereof is administered in a single dose.
10. The method for treating lung cancer as described in claim 7 , wherein about 25 to about 50 mg/m 2 of amrubicin or a pharmaceutically acceptable salt thereof is administered once a day for 3 days.
11. The method for treating lung cancer as described in claim 7 , wherein about 30 to about 45 mg/m 2 of amrubicin or a pharmaceutically acceptable salt thereof is administered once a day for 3 days.
12. The method for treating lung cancer as described in claim 7 , wherein about 35 to about 45 mg/m 2 of amrubicin or a pharmaceutically acceptable salt thereof is administered once a day for 3 days.
13. The method for treating lung cancer as described in any of claims 10 to 12 , wherein amrubicin or a pharmaceutically acceptable salt thereof is administered for continuous 3 days.
14. The method for treating lung cancer as described in claim 1 , wherein the second medicament for treating lung cancer is administered in a combined use of about 0.4 times to about 1.0 time of the maximum tolerated dose or 0.4 times to about 1.0 time of the maximum administered dose.
15. The method for treating lung cancer as described in claim 1 , in which the patient is one having failed to continue receiving the treatment with the second medicament for treating lung cancer because of side effects, and wherein said second medicament is administered in an amount that will cause reduced side effect.
16. A kit for treating lung cancer comprising
(a) a first composition comprising amrubicin or a pharmaceutically acceptable salt thereof as an active ingredient and;
(b) a second composition comprising another medicament for treating lung cancer as an active ingredient, wherein the other medicament for treating lung cancer is selected from the group consisting of irinotecan, vinorelbine and gemcitabine.