Optically active pyridine derivative and a medicament containing the same
View Patent ↗An optically active (−)-7-[2-(cyclopropylmethoxy)-6-hydroxyphenyl]-5-[(3S)-3-piperidinyl]-1,4-dihydro-2H-pyrido[2,3-d][1,3]oxazin-2-one of the formula (I) or salt thereof. The compound has an excellent anti-inflammatory activity, and other biological activity
1. An optically active (−)-7-[2-(cyclopropylmethoxy)-6-hydroxyphenyl]-5-[(3S)-3-piperidinyl]-1,4-dihydro-2H-pyrido[2,3-d][1,3]oxazin-2-one of the formula (I):
or a salt thereof.
2. The compound or a salt as claimed in claim 1 , having an optical purity of at least 90% enantiomeric excess.
3. The compound or a salt as claimed in claim 1 , having an optical purity of at least 95% enantiomeric excess.
4. A pharmaceutical composition comprising the compound or a salt thereof as claimed in claim 1 , 2 or 3 and at least one pharmaceutically acceptable excipient.
5. A pharmaceutical composition having IκB kinase inhibitory activity comprising the compound or a salt thereof as claimed in claim 1 as an active ingredient, together with a pharmaceutically acceptable excipient.
6. A method of treating an inflammatory condition involving NF-κB activity selected from the group consisting of asthma; allergic rhinitis; atopic dermatitis; hives; conjunctivitis; vernal catarrh; chronic arthrorheumatism; systemic lupus erythematosus; psoriasis; diabrotic colitis; systemic inflammatory response syndrome (SIRS); polymyositis; dermatomyositis (DM); Polyaritis nodoa (PN); mixed connective tissue disease (MCTD); Sjoegren's syndrome; and gout in a subject, comprising administering to the subject an effective amount of the compound of claim 1 , 2 , or 3 .