Use of IL-18BP for treatment of peripheral vascular diseases
View Patent ↗The invention relates to the use of an inhibitor of IL-18 in the preparation of a medicament for treatment and/or prevention of peripheral vascular diseases. The invention further relates to the use of an IL-18 inhibitor for prevention of limb amputation.
1. A method for stimulating angiogenesis in an individual affected with a peripheral vascular disease comprising administering to the individual an effective amount of a composition comprising an IL-18 binding protein (IL-18BP) and a pharmaceutically acceptable carrier.
2. The method according to claim 1 , wherein the peripheral vascular disease is peripheral arterial disease.
3. The method according to claim 1 , wherein the peripheral vascular disease is peripheral vascular disease of lower extremities.
4. The method according to claim 2 , wherein the peripheral arterial disease is peripheral arterial disease of lower extremities.
5. The method of claim 1 , wherein the peripheral vascular disease is peripheral ischemia.
6. The method of claim 5 , wherein peripheral ischemia is critical limb ischemia.
7. A method for stimulating angiogenesis in an individual having claudication resulted from limb ischemia comprising administering to the individual an effective amount of a composition comprising an IL-18BP and a pharmaceutically acceptable carrier.
8. The method according to claim 1 or 7 , wherein the IL-18BP is glycosylated at least at one site.
9. The method according to claim 1 or 7 , wherein the IL-18BP is fused to an immunoglobulin (Ig) moiety.
10. The method according to claim 1 or 7 , wherein the IL-18BP is PEGylated.
11. A method for stimulating angiogenesis in an individual affected with a peripheral vascular disease comprising administering to the individual an effective amount of a composition comprising an IL-18 binding protein (IL-18BP) and a pharmaceutically acceptable carrier, directly to the affected area.
12. The method according to claim 11 , wherein the peripheral vascular disease is peripheral arterial disease.
13. The method according to claim 11 , wherein the peripheral vascular disease is peripheral vascular disease of lower extremities.
14. The method of claim 11 , wherein the peripheral vascular disease is peripheral ischemia.
15. The method of claim 14 , wherein peripheral ischemia is critical limb ischemia.
16. The method according to claim 11 , wherein the IL-18BP is glycosylated at least at one site.
17. The method according to claim 11 , wherein the IL-18BP is fused to an immunoglobulin (Ig) moiety.
18. The method according to claim 11 , wherein the IL-18BP is PEGylated.
19. The method of claim 11 , wherein the administration is subcutaneous.
20. The method of claim 11 , wherein the administration is intramuscular.
21. The method of claim 11 , wherein the administration is topical.
22. A method for stimulating angiogenesis in an individual affected with Buerger's Disease (Thromboangiitis Obliterans) comprising administering to the individual an effective amount of a composition comprising an IL-18 binding protein and a pharmaceutically acceptable carrier.
23. A method for stimulating angiogenesis in an individual affected with Buerger's Disease comprising administering to the individual an effective amount of a composition comprising an IL-18 binding protein and a pharmaceutically acceptable carrier, directly to the affected area.