Compounds and methods

1. A compound of Formula I:

wherein:

X is selected from C 1 -C 8 alkyl, halo, —OR 10 , —NR 14 R 15 , nitro, cyano, —COOR 10 , —COR 13 , —OCOR 13 , —N(R 17 )COR 13 , —N(R 17 )CONR 14 R 15 , —N(R 17 )COOR 13 , —SO 3 H, —SO 2 NR 14 R 15 , —C(═NR 17 )NR 14 R 15 , —N(R 17 )SO 2 R 16 , and a 5 or 6-membered heterocyclic group;

or X and an adjacent R 3 , taken together with the atoms to which they are bonded, form an alkylenedioxy moiety;

Z is CH, CR 3 or N, wherein when Z is CH or CR 3 , k is 0-4 and t is 0 or 1, and when Z is N, k is 0-3 and t is 0;

Y is selected from —O—, —S—, —N(R 10 )-, and —C(R 4 )(R 5 )—;

W 1 is selected from C 3 -C 8 cycloalkyl, aryl and Het, wherein said C 3 -C 8 cycloalkyl, aryl and Het are optionally unsubstituted or substituted with one or more groups independently selected from halo, cyano, nitro, C 1 -C 6 alkyl, C 3 -C 6 alkenyl, C 3 -C 6 alkynyl, —C 0 -C 6 alkyl-CO 2 R 10 , —C 0 -C 6 alkyl-C(O)SR 10 , —C 0 -C 6 alkyl-CONR 11 R 12 , —C 0 -C 6 alkyl-COR 13 , —C 0 -C 6 alkyl-NR 11 R 12 , —C 0 -C 6 alkyl-SR 10 , —C 0 -C 6 alkyl-OR 10 , —C 0 -C 6 alkyl-SO 3 H, —C 0 -C 6 alkyl-SO 2 NR 11 R 12 , —C 0 -C 6 alkyl-SO 2 R 10 , —C 0 -C 6 alkyl-SOR 13 , —C 0 -C 6 alkyl-OCOR 13 , —C 0 -C 6 alkyl-OC(O)NR 11 R 12 , —C 0 -C 6 alkyl-OC(O)OR 13 , —C 0 -C 6 alkyl-NR 11 C(O)OR 13 , —C 0 -C 6 alkyl-NR 11 C(O)NR 11 R 12 , and —C 0 -C 6 alkyl-NR 11 COR 13 , where said C 1 -C 6 alkyl, is optionally unsubstituted or substituted by one or more halo substituents;

W 2 is selected from H, halo, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, —C 0 -C 6 alkyl-NR 11 R 12 , —C 0 -C 6 alkyl-SR 10 , —C 0 -C 6 alkyl-OR 10 , —C 0 -C 6 alkyl-CO 2 R 10 , —C 0 -C 6 alkyl-C(O)SR 10 , —C 0 -C 6 alkyl-CONR 11 R 12 , —C 0 -C 6 alkyl-COR 13 , —C 0 -C 6 alkyl-OCOR 13 , —C 0 -C 6 alkyl-OCONR 11 R 12 , —C 0 -C 6 alkyl-NR 11 CONR 11 R 12 , —C 0 -C 6 alkyl-NR 11 COR 13 , —C 0 -C 6 alkyl-Het, —C 0 -C 6 alkyl-aryl and —C 0 -C 6 alkyl-C 3 -C 7 cycloalkyl, wherein said C 1 -C 6 alkyl is optionally unsubstituted or substituted by one or more halo substituents, and wherein the C 3 -C 7 cycloalkyl, aryl and Het moieties of said —C 0 -C 6 alkyl-Het, —C 0 -C 6 alkyl-aryl and —C 0 -C 6 alkyl-C 3 -C 7 cycloalkyl are optionally unsubstituted or substituted with one or more groups independently selected from halo, cyano, nitro, C 1 -C 6 alkyl, C 3 -C 6 alkenyl, C 3 -C 6 alkynyl, —C 0 -C 6 alkyl-CO 2 R 10 , —C 0 -C 6 alkyl-C(O)SR 10 , —C 0 -C 6 alkyl-CONR 11 R 12 , —C 0 -C 6 alkyl-COR 13 , —C 0 -C 6 alkyl-NR 11 R 12 , —C 0 -C 6 alkyl-SR 10 , —C 0 -C 6 alkyl-OR 10 , —C 0 -C 6 alkyl-SO 3 H, —C 0 -C 6 alkyl-SO 2 NR 11 R 12 , —C 0 -C 6 alkyl-SO 2 R 10 , —C 0 -C 6 alkyl-SOR 13 , —C 0 -C 6 alkyl-OCOR 13 , —C 0 -C 6 alkyl-OC(O)NR 11 R 12 , —C 0 -C 6 alkyl-OC(O)OR 13 , —C 0 -C 6 alkyl-NR 11 C(O)OR 13 , —C 0 -C 6 alkyl-NR 11 C(O)NR 11 R 12 , and —C 0 -C 6 alkyl-NR 11 COR 13 , where said C 1 -C 6 alkyl, is optionally unsubstituted or substituted by one or more halo substituents;

W 3 is selected from the group consisting of: H, halo, C 1 -C 6 alkyl, —C 0 -C 6 alkyl-NR 11 R 12 , —C 0 -C 6 alkyl-SR 10 , —C 0 -C 6 alkyl-OR 10 , —C 0 -C 6 alkyl-CO 2 R 10 , —C 0 -C 6 alkyl-C(O)SR 10 , —C 0 -C 6 alkyl-CONR 11 R 12 , —C 0 -C 6 alkyl-COR 13 , —C 0 -C 6 alkyl-OCOR 13 , —C 0 -C 6 alkyl-OCONR 11 R 12 , —C 0 -C 6 alkyl-NR 11 CONR 11 R 12 , —C 0 -C 6 alkyl-NR 11 COR 13 , —C 0 -C 6 alkyl-Het, —C 1 -C 6 alkyl-aryl and —C 1 -C 6 alkyl-C 3 -C 7 cycloalkyl, wherein said C 1 -C 6 alkyl is optionally unsubstituted or substituted by one or more halo substituents;

Q is selected from C 3 -C 8 cycloalkyl, Ar and Het; wherein said C 3 -C 8 cycloalkyl, Ar and Het are optionally unsubstituted or substituted with one or more groups independently selected from halo, cyano, nitro, C 1 -C 6 alkyl, C 3 -C 6 alkenyl, C 3 -C 6 alkynyl, —C 0 -C 6 alkyl-CO 2 R 10 , —C 0 -C 6 alkyl-C(O)SR 10 , —C 0 -C 6 alkyl-CONR 11 R 12 , —C 0 -C 6 alkyl-COR 13 , —C 0 -C 6 alkyl-NR 11 R 12 , —C 0 -C 6 alkyl-SR 10 , —C 0 -C 6 alkyl-OR 10 , —C 0 -C 6 alkyl-SO 3 H, —C 0 -C 6 alkyl-SO 2 NR 11 R 12 , —C 0 -C 6 alkyl-SO 2 R 10 , —C 0 -C 6 alkyl-SOR 13 , —C 0 -C 6 alkyl-OCOR 13 , —C 0 -C 6 alkyl-OC(O)NR 11 R 12 , —C 0 -C 6 alkyl-OC(O)OR 13 , —C 0 -C 6 alkyl-NR 11 C(O)OR 13 , —C 0 -C 6 alkyl-NR 11 C(O)NR 11 R 12 , and —C 0 -C 6 alkyl-NR 11 COR 13 , where said C 1 -C 6 alkyl is optionally unsubstituted or substituted by one or more halo substituents;

p is 0-8;

n is 3;

m is 0 or 1;

q is 0 or 1;

t is 0 or 1;

each R 1 and R 2 are independently selected from H, halo, C 1 -C 6 alkyl, C 3 -C 6 alkenyl, C 3 -C 6 alkynyl, —C 0 -C 6 alkyl-NR 11 R 12 , —C 0 -C 6 alkyl-OR 10 , —C 0 -C 6 alkyl-SR 10 , —C 1 -C 6 alkyl-Het, —C 1 -C 6 alkyl-Ar and —C 1 -C 6 alkyl-C 3 -C 7 cycloalkyl, or R 1 and R 2 together with the carbon to which they are attached form a 3-5 membered carbocyclic or heterocyclic ring, wherein said heterocyclic ring contains one, or more heteroatoms selected from N, O, and S, where any of said C 1 -C 6 alkyl is optionally unsubstituted or substituted by one or more halo substituents;

each R 3 is the same or different and is independently selected from halo, cyano, nitro, C 1 -C 6 alkyl, C 3 -C 6 alkenyl, C 3 -C 6 alkynyl, —C 0 -C 6 alkyl-Ar, —C 0 -C 6 alkyl-Het, —C 0 -C 6 alkyl-C 3 -C 7 cycloalkyl, —C 0 -C 6 alkyl-CO 2 R 10 , —C 0 -C 6 alkyl-C(O)SR 10 , —C 0 -C 6 alkyl-CONR 11 R 12 , —C 0 -C 6 alkyl-COR 13 , —C 0 -C 6 alkyl-NR 11 R 12 , —C 0 -C 6 alkyl-SR 10 , —C 0 -C 6 alkyl-OR 10 , —C 0 -C 6 alkyl-SO 3 H, —C 0 -C 6 alkyl-SO 2 NR 11 R 12 , —C 0 -C 6 alkyl-SO 2 R 10 , —C 0 -C 6 alkyl-SOR 13 , —C 0 -C 6 alkyl-OCOR 13 , —C 0 -C 6 alkyl-OC(O)NR 11 R 12 , —C 0 -C 6 alkyl-OC(O)OR 13 , —C 0 -C 6 alkyl-NR 11 C(O)OR 13 , —C 0 -C 6 alkyl-NR 11 C(O)NR 11 R 12 , and —C 0 -C 6 alkyl-NR 11 COR 13 , wherein said C 1 -C 6 alkyl is optionally unsubstituted or substituted by one or more halo substituents;

each R 4 and R 5 is independently selected from H, halo, C 1 -C 6 alkyl, —C 0 -C 6 alkyl-Het, —C 0 -C 6 alkyl-Ar and —C 0 -C 6 alkyl-C 3 -C 7 cycloalkyl;

R 6 and R 7 are each independently selected from H, halo, C 1 -C 6 alkyl, —C 0 -C 6 alkyl-Het, —C 0 -C 6 alkyl-Ar and —C 0 -C 6 alkyl-C 3 -C 7 cycloalkyl;

R 8 and R 9 are each independently selected from H, halo, C 1 -C 6 alkyl, —C 0 -C 6 alkyl-Het, —C 0 -C 6 alkyl-Ar and —C 0 -C 6 alkyl-C 3 -C 7 cycloalkyl;

R 10 is selected from H, C 1 -C 6 alkyl, C 3 -C 6 alkenyl, C 3 -C 6 alkynyl, —C 0 -C 6 alkyl-Ar, —C 0 -C 6 alkyl-Het and —C 0 -C 6 alkyl-C 3 -C 7 cycloalkyl;

each R 11 and each R 12 are independently selected from H, C 1 -C 6 alkyl, C 3 -C 6 alkenyl, C 3 -C 6 alkynyl, —C 0 -C 6 alkyl-Ar, —C 0 -C 6 alkyl-Het and —C 0 -C 6 alkyl-C 3 -C 7 cycloalkyl, or R 11 and R 12 together with the nitrogen to which they are attached form a 4-7 membered heterocyclic ring which optionally contains one or more additional heteroatoms selected from N, O, and S;

R 13 is selected from C 1 -C 6 alkyl, C 3 -C 6 alkenyl, C 3 -C 6 alkynyl, —C 0 -C 6 alkyl-Ar, —C 0 -C 6 alkyl-Het and —C 0 -C 6 alkyl-C 3 -C 7 cycloalkyl;

R 14 and R 15 are each independently selected from H, C 1 -C 6 alkyl, C 3 -C 6 alkenyl, C 3 -C 6 alkynyl, —C 0 -C 6 alkyl-Ar, —C 0 -C 6 alkyl-Het, —C 0 -C 6 alkyl-C 3 -C 7 cycloalkyl, —C 0 -C 6 alkyl-O—Ar, —C 0 -C 6 alkyl-O-Het, —C 0 -C 6 alkyl-O—C 3 -C 7 cycloalkyl, —C 0 -C 6 alkyl-S(O) x —C 1 -C 6 alkyl, —C 0 -C 6 alkyl-S(O) x —Ar, —C 0 -C 6 alkyl-S(O) x -Het, —C 0 -C 6 alkyl-S(O) x —C 3 -C 7 cycloalkyl, —C 0 -C 6 alkyl-NH-Het, —C 0 -C 6 alkyl-NH—C 3 -C 7 cycloalkyl, —C 0 -C 6 alkyl-N(C 1 -C 4 alkyl)-Ar, —C 0 -C 6 alkyl-N(C 1 -C 4 alkyl)-Het, —C 0 -C 6 alkyl-N(C 1 -C 4 alkyl)-C 3 -C 7 cycloalkyl, —C 0 -C 6 alkyl-Ar, —C 0 -C 6 alkyl-Het and —C 0 -C 6 alkyl-C 3 -C 7 cycloalkyl, where x is 0, 1 or 2, or R 14 and R 15 , together with the nitrogen to which they are attached, form a 4-7 membered heterocyclic ring which optionally contains one or more additional heteroatoms selected from N, O, and S, wherein said C 1 -C 6 alkyl is optionally substituted by one or more of the substituents independently selected from the group halo, —OH, —SH, —NH 2 , —NH(unsubstituted C 1 -C 6 alkyl), —N(unsubstituted C 1 -C 6 alkyl)(unsubstituted C 1 -C 6 alkyl), unsubstituted —OC 1 -C 6 alkyl, —CO 2 H, —CO 2 (unsubstituted C 1 -C 6 alkyl), —CONH 2 , —CONH(unsubstituted C 1 -C 6 alkyl), —CON(unsubstituted C 1 -C 6 alkyl)(unsubstituted C 1 -C 6 alkyl), —SO 3 H, —SO 2 NH 2 , —SO 2 NH(unsubstituted C 1 -C 6 alkyl) and —SO 2 N(unsubstituted C 1 -C 6 alkyl)(unsubstituted C 1 -C 6 alkyl);

R 16 is C 1 -C 6 alkyl, —C 0 -C 6 alkyl-Ar or —C 0 -C 6 alkyl-Het; and

R 17 is H, C 1 -C 6 alkyl, —C 0 -C 6 alkyl-Ar or —C 0 -C 6 alkyl-Het;

wherein each Ar or aryl independently represent a substituted or unsubstituted carbocyclic aromatic group, which may be optionally fused to another carbocyclic aromatic group moiety or to a cycloalkyl group moiety, wherein said Ar or aryl is optionally substituted by one or more of the substituents independently selected from the group halo, cyano, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, —C 0 -C 6 alkyl-OH, —C 0 -C 6 alkyl-SH, —C 0 -C 6 alkyl-NR′R″, C 3 -C 6 alkenyl, —OC 1 -C 6 alkyl, —OC 1 -C 6 alkenyl, —C 0 -C 6 alkyl-COR′, —C 0 -C 6 alkyl-CO 2 R′, —C 0 -C 6 alkyl-CONR′R″, —OC 0 -C 6 alkyl-CO 2 H, —OC 2 -C 6 alkyl-NR′R″, —C 0 -C 6 alkyl-C(═NR′)NR′R″, and —C 0 -C 6 alkyl-SO 2 NR′R″, wherein each R′ and R″ are independently selected from H and unsubstituted C 1 -C 6 alkyl,

each Het independently represents a monocyclic 5- to 7-membered, a bicyclic 7- to 10-membered or a tricyclic 11- to 18-membered heterocyclic ring group which is saturated, unsaturated or aromatic, and consists of carbon atoms and from one to three heteroatoms selected from N, O and S, wherein the N or S heteroatoms of said Het are optionally oxidized or the N heteroatom is optionally quaternized, wherein said Het is optionally unsubstituted or substituted by one or more of the substituents independently selected from the group halo, cyano, C 1 -C 6 alkyl (which specifically includes C 1 -C 6 haloalkyl, —C 0 -C 6 alkyl-OH, —C 0 -C 6 alkyl-SH and —C 0 -C 6 alkyl-NR′R″), C 3 -C 6 alkenyl, oxo, —OC 1 -C 6 alkyl, —OC 1 -C 6 alkenyl, —C 0 -C 6 alkyl-COR′, —C 0 -C 6 alkyl-CO 2 R′, —C 0 -C 6 alkyl-CONR′R″, —OC 0 -C 6 alkyl-CO 2 H, —OC 2 -C 6 alkyl-NR′R″, —C 0 -C 6 alkyl-C(═NR′)NR′R″ and —C 0 -C 6 alkyl-SO 2 NR′R″, wherein each R′ and R″ are independently selected from H and unsubstituted C 1 -C 6 alkyl;

provided that X is not COOR 10 when Y is —O—, p is 0-8, n is 3, m is 1, q is 0 or 1, t is 0, each R 1 and R 2 is independently selected from H, C 1 -C 6 alkyl, —OH, —O—C 1 -C 6 alkyl, —SH, and —S—C 1 -C 6 alkyl, each R 4 , R 5 , R 6 , R 7 , R 8 and R 9 are independently H or C 1 -C 4 alkyl, k is 0 or 1, W 3 is H, W 1 and W 2 are each independently selected from C 3 -C 8 cycloalkyl and aryl and R 3 and Q are as defined above; or

provided that the compound is not

5-[3-[[(3,4-dichlorophenyl)methyl][2-(2-naphthalenyl)ethyl]amino]propoxy]-3-methoxy-1,2-benzenedicarboxylic acid, or

5-[3-[[(3,4-dichlorophenyl)methyl][2-(2-naphthalenyl)ethyl]amino]propoxy]-3-methoxy-1,2-benzenedicarboxylic acid, dimethyl ester;

or a pharmaceutically acceptable salt or hydrate thereof.

2. The compound according to claim 1 , wherein p is 0, 1 or 2.

3. The compound according to claim 1 , wherein t is 0.

4. The compound according to claim 1 , wherein R 1 and R 2 are independently H or C 1 -C 4 alkyl or R 1 and R 2 together with the carbon to which they are attached form a 3-5 membered carbocyclic ring.

5. The compound according to claim 1 , wherein k is 0 or 1.

6. The compound according to claim 1 , wherein R 3 is selected from halo, C 1 -C 4 alkyl and C 1 -C 4 alkoxy.

7. The compound according to claim 1 , wherein X is selected from C 1 -C 6 alkyl, halo, —OR 10 , —NR 14 R 15 , cyano, —COR 13 , —COOR 10 , —OCOR 13 , —N(R 17 )CONR 14 R 15 , —N(R 17 )COR 13 , —SO 2 NR 14 R 15 , —N(R 17 )SO 2 R 16 , and a 5 or 6-membered heterocyclic group or X and an adjacent R 3 , taken together with the atoms to which they are bonded, form an alkylenedioxy moiety.

8. The compound according to claim 7 , wherein R 10 is H, C 1 -C 4 alkyl or phenyl; R 13 is H, C 1 -C 4 alkyl, —C 0 -C 4 alkyl-C 3 -C 7 cycloalkyl, or —C 0 -C 4 alkyl-phenyl; R 14 and R 15 are each independently selected from H, C 1 -C 6 alkyl, —C 0 -C 4 alkyl-Ar, —C 0 -C 4 alkyl-Het, —C 0 -C 4 alkyl-C 3 -C 7 cycloalkyl, —C 0 -C 4 alkyl-O—Ar, —C 0 -C 4 alkyl-O-Het, —C 0 -C 4 alkyl-O—C 3 -C 7 cycloalkyl, —C 0 -C 4 alkyl-S(O) 2 —C 1 -C 4 alkyl, —C 0 -C 4 alkyl-S(O) 2 —Ar, —C 0 -C 4 alkyl-S(O) 2 -Het, —C 0 -C 4 alkyl-S(O) 2 —C 3 -C 7 cycloalkyl, —C 0 -C 4 alkyl-NH—Ar, —C 0 -C 4 alkyl-NH-Het, —C 0 -C 4 alkyl-NH—C 3 -C 7 cycloalkyl, —C 0 -C 4 alkyl-N(C 1 -C 4 alkyl)-Ar, —C 0 -C 4 alkyl-N(C 1 -C 4 alkyl)-Het, —C 0 -C 4 alkyl-N(C 1 -C 4 alkyl)-C 3 -C 7 cycloalkyl, —C 0 -C 4 alkyl-Ar, —C 0 -C 4 alkyl-Het and —C 0 -C 4 alkyl-C 3 -C 7 cycloalkyl, or R 14 and R 15 , together with the nitrogen to which they are attached, form a 4-7 membered heterocyclic ring which optionally contains one or more additional heteroatoms selected from N, O, and S, wherein said C 1 -C 6 alkyl is optionally substituted by one or more of the substituents independently selected from the group halo, —OH, —SH, —NH 2 , —NH(unsubstituted C 1 -C 4 alkyl), —N(unsubstituted C 1 -C 4 alkyl)(unsubstituted C 1 -C 4 alkyl), unsubstituted —OC 1 -C 4 alkyl, —CO 2 H, —CO 2 (unsubstituted C 1 -C 4 alkyl), —CONH 2 , —CONH(unsubstituted C 1 -C 4 alkyl), —CON(unsubstituted C 1 -C 4 alkyl)(unsubstituted C 1 -C 4 alkyl), —SO 3 H, —SO 2 NH 2 , —SO 2 NH(unsubstituted C 1 -C 4 alkyl) and —SO 2 N(unsubstituted C 1 -C 4 alkyl)(unsubstituted C 1 -C 4 alkyl); R 16 is C 1 -C 4 alkyl or phenyl; and R 17 is H or C 1 -C 4 alkyl.

9. The compound according to claim 1 wherein each R 4 and R 5 are independently selected from H and C 1 -C 3 alkyl.

10. The compound according to claim 1 , wherein R 8 and R 9 are each H.

11. The compound according to claim 1 , wherein Q is a substituted or unsubstituted phenyl or furanyl group or a benzo[1,3]dioxyl or benzo[1,4]dioxyl group containing one, two or three substituents selected from halo, C 1 -C 4 alkyl; C 1 -C 4 alkylthio; or —NR Q1 R Q2 , where R Q1 and R Q2 taken together with the nitrogen to which they are attached form a 4-7 membered heterocyclic ring, which may optionally contain one or more additional heteroatoms selected form N, O and S.

12. The compound according to claim 11 , wherein said substituents are selected from fluoro, chloro, trifluoromethyl, tert-butyl, isopropyl, methylthio and piperidin-1-yl.

13. The compound according to claim 1 , wherein m is 0 or m is 1 and R 6 and R 7 are each H.

14. The compound according to claim 1 , wherein W 1 is phenyl, naphthyl, thienyl, pyridyl, furanyl, pyrrolyl, cyclohexyl, cyclopentyl, morpholinyl, or pyrrolidinyl, where each phenyl, naphthyl, thienyl, pyridyl, furanyl, pyrrolyl, cyclohexyl, cyclopentyl, morpholinyl, or pyrrolidinyl may be optionally substituted from 1 to 3 times with one or more of the substituents independently selected from C 1 -C 4 alkyl, —OH, halo, —O—C 1 -C 4 alkyl, and —C 1 -C 4 haloalkyl.

15. The compound according to claim 1 , wherein W 2 is C 1 -C 4 alkyl, C 2 -C 4 alkynyl, C 3 -C 6 cycloalkyl, aryl, Het hydroxy, aryloxy-, C 1 -C 4 alkoxy-, —OCOC 1 -C 4 alkyl, —OCOaryl, or —NR W1 R W2 , where R W1 and R W2 are independently H or C 1 -C 4 alkyl or taken together with the nitrogen to which they are attached form a 4-7 membered heterocyclic ring, which may optionally contain one or more additional heteroatoms selected form N, O and S.

16. The compound according to claim 1 , wherein W 3 is H or C 1 -C 4 alkyl.

17. The compound according to claim 1 , wherein X is selected from C 1 -C 6 alkyl, halo, —OR 10 , —NR 14 R 15 , cyano, —COR 13 , —COOR 10 , —OCOR 13 , —N(R 17 )CONR 14 R 15 , —N(R 17 )COR 13 , —SO 2 NR 14 R 15 , —N(R 17 )SO 2 R 16 , and a 5 or 6-membered heterocyclic group or X and an adjacent R 3 , taken together with the atoms to which they are bonded, form an alkylenedioxy moiety, where R 10 is H, C 1 -C 4 alkyl or phenyl, R 13 is H, C 1 -C 4 alkyl, —C 0 -C 4 alkyl-C 3 -C 7 cycloalkyl, or —C 0 -C 4 alkyl-phenyl, R 14 and R 15 are each independently selected from H, C 1 -C 6 alkyl, —C 0 -C 4 alkyl-Ar, —C 0 -C 4 alkyl-Het, —C 0 -C 4 alkyl-C 3 -C 7 cycloalkyl, —C 0 -C 4 alkyl-O—Ar, —C 0 -C 4 alkyl-O-Het, —C 0 -C 4 alkyl-O—C 3 -C 7 cycloalkyl, —C 0 -C 4 alkyl-S(O) 2 -C 1 -C 4 alkyl, —C 0 -C 4 alkyl-S(O) 2 —Ar, —C 0 -C 4 alkyl-S(O) 2 -Het, —C 0 -C 4 alkyl-S(O) 2 -C 3 -C 7 cycloalkyl, —C 0 -C 4 alkyl-NH—Ar, —C 0 -C 4 alkyl-NH-Het, —C 0 -C 4 alkyl-NH—C 3 -C 7 cycloalkyl, —C 0 -C 4 alkyl-N(C 1 -C 4 alkyl)-Ar, —C 0 -C 4 alkyl-N(C 1 -C 4 alkyl)-Het, —C 0 -C 4 alkyl-N(C 1 -C 4 alkyl)-C 3 -C 7 cycloalkyl, —C 0 -C 4 alkyl-Ar, —C 0 -C 4 alkyl-Het and —C 0 -C 4 alkyl-C 3 -C 7 cycloalkyl, or R 14 and R 15 , together with the nitrogen to which they are attached, form a 4-7 membered heterocyclic ring which optionally contains one or more additional heteroatoms selected from N, O, and S, wherein said C 1 -C 6 alkyl is optionally substituted by one or more of the substituents independently selected from the group halo, —OH, —SH, —NH 2 , —NH(unsubstituted C 1 -C 4 alkyl), —N(unsubstituted C 1 -C 4 alkyl)(unsubstituted C 1 -C 4 alkyl), unsubstituted —OC 1 -C 4 alkyl, —CO 2 H, —CO 2 (unsubstituted C 1 -C 4 alkyl), —CONH 2 , —CONH(unsubstituted C 1 -C 4 alkyl), —CON(unsubstituted C 1 -C 4 alkyl)(unsubstituted C 1 -C 4 alkyl), —SO 3 H, —SO 2 NH 2 , —SO 2 NH(unsubstituted C 1 -C 4 alkyl) and —SO 2 N(unsubstituted C 1 -C 4 alkyl)(unsubstituted C 1 -C 4 alkyl), R 16 is C 1 -C 4 alkyl or phenyl, and R 17 is H or C 1 -C 4 alkyl; p is 0, 1 or 2; R 1 and R 2 are independently H or C 1 -C 4 alkyl or R 1 and R 2 together with the carbon to which they are attached form a 3-5 membered carbocyclic ring; k is 0 or k is 1 and R 3 is halo, C 1 -C 4 alkyl or C 1 -C 4 alkoxy; n is 3 and each R 4 and R 5 are independently selected from H and C 1 -C 3 alkyl; Z is CH or N; Y is —O— or —C(R 4 )(R 5 )—; q is 1; R 8 and R 9 are each H; Q is a substituted or unsubstituted phenyl or furanyl group or a benzo[1,3]dioxyl or benzo[1,4]dioxyl group, where the substituted phenyl or furanyl group contains one, two or three substituents selected from halo, C 1 -C 4 alkyl; C 1 -C 4 alkylthio; or —NR Q1 R Q2 , where R Q1 and R Q2 taken together with the nitrogen to which they are attached form a 4-7 membered heterocyclic ring, which may optionally contain one or more additional heteroatoms selected form N, O and S; t is 0 or 1; m is 0 or 1; R 6 and R 7 are independently selected from H and C 1 -C 4 alkyl; W 1 is unsubstituted phenyl, naphthyl, pyridyl, thienyl or pyrrolyl or substituted phenyl or pyridyl containing one or two substituents independently selected from halo, alkyl and alkoxy, specifically, chloro, methyl and methoxy; W 2 is C 1 -C 4 alkyl, C 2 -C 4 alkynyl, C 3 -C 6 cycloalkyl, aryl, Het hydroxy, aryloxy-, C 1 -C 4 alkoxy-, —OCOC 1 -C 4 alkyl, —OCOaryl, or —NR W1 R W2 , where R W1 and R W2 are independently H or C 1 -C 4 alkyl or taken together with the nitrogen to which they are attached form a 4-7 membered heterocyclic ring, which may optionally contain one or more additional heteroatoms selected form N, O and S; W 3 is H or C 1 -C 4 alkyl; or a pharmaceutically acceptable salt or hydrate thereof.

18. The compound according to claim 1 , wherein X is chloro, bromo, cyano, carboxy-, methylcarboxy-, hydroxy, methoxy, methyl, trifluoromethyl, 1,3-dihydroxy-prop-2-yl (—CH(CH 2 OH) 2 , isopropyl, n-butyl, isobutyl, 2,2-dimethylpropyl, phenylcarbonyl, triazolyl, tetrazolyl, —NH 2 , —NHCH 3 , —NHCH 2 CH 3 , —NHCH 2 CH 2 CH 3 , —NHCH 2 CH 2 CH 2 CH 3 , —NHCH 2 CH 2 CH 2 CH 2 CH 2 CH 3 , —NHCH 2 C(CH 3 ) 3 , —NHCH 2 CH(CH 3 ) 2 , —NHCH 2 CH 2 CH(CH 3 ) 2 , —NH-cyclopentyl, —NH-phenyl, —NHCH2-cyclopropyl, —NHCH(CH 3 ) 2 , —NHCH 2 CF 3 , —N(CH 3 ) 2 , —N(CH 2 CH 3 ) 2 , —NHCH(CH 2 CH 3 ) 2 , —NHCH 2 CH(CH 2 CH 3 ) 2 , —NHCH 2 CH 2 OH, —NHCH 2 CO 2 H, —N(CH 3 )CH 2 CO 2 H, —NHC(CH 3 ) 2 CO 2 H, —NHCH(CH 3 )CO 2 H, —(R)—NHCH(CH 3 )CO 2 H, —(S)—NHCH(CH 3 )CO 2 H, —NHCH 2 -1H-imidazol-2-yl, —NHCH 2 -(1-CH 3 -iimidazol-2-yl, —NH-(pyrimidin-2-yl), -morpholin-4-yl, -thiomorpholin-4-yl, -piperidin-1-yl, -piperidin-1-yl-(4-carboxylic acid), -piperidin-1-yl-(4-acetic acid), -piperidin-4-yl-(1-acetic acid), -2,5-dimethyl-pyrrol-1-yl, -pyrrolidin-1-yl, —((R)-2-CO 2 H-pyrrolidin-1-yl), —((S)-2-CO 2 H-pyrrolidin-1-yl), -piperazin-1-yl, -(4-methyl-piperazin-1-yl), -piperazin-1-yl-(4-acetic acid), —NHCH 2 -(5-bromo-thien-2-yl), —NHCH 2 -1H-imidazol-2-yl, —NHCH 2 -(1-methyl-imidazol-2-yl, —NHCOCH 3 , —N(CH 3 )COCH 3 , —NHCO 2 C(CH 3 ) 3 , —NHCOCH 2 CH 3 , —NHCOC(CH 3 ) 2 , —NHCO-furan-2-yl, —N(CH 3 )CO-furan-2-yl, —NHCO-thien-2-yl, —NHCO-cyclopropyl, —NHCO-(5-bromo-thien-2-yl, —NHCO-(2,5-dimethyl-pyrrol-3-yl), —NHSO 2 CH 3 , —N(CH 3 )SO 2 CH 3 , —NHSO 2 CF 3 , —NHSO 2 phenyl, —N(CH 3 )SO 2 phenyl, —NHSO 2 CH 2 CH 3 , —NHSO 2 CH 2 CF 3 , —NHSO 2 CH 2 CH 2 CH 3 , —NHSO 2 CH(CH 3 ) 2 ,—NHCONH(2-chlorophenyl), —N(CH 3 )CONH(3,5-dimethoxyphenyl), —N(CH 3 )CONH(2-chlorophenyl), —N(CH 3 )CO-(benzo[1,3]diox-5-yl), —SO 2 NHCH 3 , and —SO 2 N(CH 3 ) 2 ; p is 0, 1 or 2; R 1 and R 2 are H C 1 -C 4 alkyl or R 1 and R 2 together with the carbon to which they are attached form a 3, 4 or 5 membered carbocyclic ring; Z is CH of N; k is 0 or k is 1 and R 3 is methyl, trifluoromethyl, chloro or methoxy; n is 3 and R 4 and R 5 are independently selected from H and methyl; Y is —O— or —C(R 4 )(R 5 )—; q is 1; R 8 and R 9 are each H; Q is 2-chloro-3-(trifluoromethyl)phenyl, 3-methyl-4-fluoro-phenyl, 4-tert-butyl-phenyl, 4-(methylthio)phenyl, 2,4,5-trifluoro-phenyl, 4-isopropyl-phenyl, 5-(piperidin-1-yl)-furan-2-yl, benzo[1,3]diox-5-yl, or 2,3-dihydrobenzo[1,4]dioxin-6-yl; t is 0 or 1; m is 0 or 1; R 6 and R 7 are independently selected from H and methyl; W 1 is phenyl, naphth-1-yl, pyrid-2-yl, 4-methyl-pyrid-2-yl, thien-2-yl, thien-3-yl, pyrrol-2-yl, 2-chlorophenyl, 3-chlorophenyl, 4-chlorophenyl, 2-methoxyphenyl, or 4-methoxyphenyl; W 2 is methyl, ethyl, ethynyl, isopropyl, n-butyl, 2-methylpropyl, trifluorormethyl, cyclohexyl, unsubstituted phenyl, hydroxy, methoxy, phenoxy, dimethylamino, morpholin-4-yl, phenylcarbonyloxy, or methylcarbonyloxy; W 3 is H or methyl; or a pharmaceutically acceptable salt or hydrate thereof.

19. The compound according to claim 1 , wherein W 1 and W 2 are not each independently C 3 -C 8 cycloalkyl or aryl or W 3 is not H or any one of R 6 or R 7 is not H or R 8 and R 9 are each C 1 -C 4 alkyl when:

X is COOR 10 ;

Z is CH or CR 3 and k is 0-4 or Z is N and k is 0-3;

p is 0-8;

n is 3;

q is 0 or 1;

Q is selected from optionally unsubstituted or substituted C 3 -C 8 cycloalkyl, phenyl and monocyclic Het;

each R 1 and R 2 is independently selected from H, C 1 -C 6 alkyl, —OH, —O—C 1 -C 6 alkyl, —SH, and —S—C 1 -C 6 alkyl; and

each R 3 is the same or different and is independently selected from halo, cyano, nitro, —CONR 12 R 13 , —COR 14 , —SR 11 , —SO 2 R 11 , —SOR 14 , —OCOR 14 and optionally unsubstituted or substituted C 1 -C 6 alkyl, C 3 -C 6 alkenyl, -5-6 membered-Het, —C 0 -C 6 alkyl-CO 2 R 11 , or —C 0 -C 6 alkyl-NR 12 R 13 .

20. A compound selected from:

2-(3-{3-[[2-Chloro-3-(trifluoromethyl)benzyl](2,2-dephenylethyl)amino]propoxy}phenyl)-ethanol; 2-(3-{3-[[2-Chloro-3-(trifluoromethyl)benzyl](2,2-diphenylethyl)amino]propoxy}-phenyl)acetic acid, N-oxide; (3-{3-[[2-Chloro-3-(trifluoromethyl)benzyl](2,2-diphenylethyl)amino]propoxy}-bromobenzene; (4-{3-[[2-Chloro-3-(trifluoromethyl)benzyl](2,2-diphenylethyl)amino]propoxy}-bromobenzene; (2-Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenylethyl)-{3-[3-(1,2,4-triazol-3-ylmethyl)-phenoxy]-propyl}-amine; (2-Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-{3-[3-(1,2,3,4-tetrazol-5-ylmethyl)-phenoxy]-propyl}-amine; (2-Chloro-3-trifluoromethyl-benzyl)-(2-cyclohexyl-2-phenyl-ethyl)-{3-[3-(1,2,3,4-tetrazol-5-ylmethyl)-phenoxy]-propyl}-amine; (S)-2-Chloro-3-trifluoromethyl-benzyl)-(2-phenyl-propyl)-{3-[3-(1,2,3,4-tetrazol-3-ylmethyl)-phenoxy]-propyl}-amine; (R)-(2-Chloro-3-trifluoromethyl-benzyl)-(2-phenyl-propyl)-{3-[3-(1,2,3,4-tetrazol-3-ylmethyl)-phenoxy]-propyl}-amine; (S)-2-(3-{3-[[2-Chloro-3-(trifluoromethyl)benzyl](2-phenyl-propyl)amino]propoxy}-phenyl)acetic acid; (R)-2-(3-{3-[[2-Chloro-3-(trifluoromethyl)benzyl](2-phenyl-propyl)amino]propoxy}-phenyl)acetic acid; Chloro-3-(trifluoromethyl)benzyl]naphthalen-1-ylmethyl-amino]propoxy}-phenyl)acetic acid; 2-(3-{3-[[2-Chloro-3-(trifluoromethyl)benzyl]-benzylamino]propoxy}-phenyl)acetic acid; 2-(3-{3-[[2-Chloro-3-(trifluoromethyl)-benzyl]phenethylamino]propoxy}-phenyl)acetic acid; 2-(3-{3-[[2-Chloro-3-(trifluoromethyl)benzyl](2-hydroxy-2-phenyl-ethyl)amino]propoxy}-phenyl)acetic acid; 2-(3-{3-[[2-Chloro-3-(trifluoromethyl)benzyl](2-acetoxy-2-phenyl-ethyl)amino]propoxy}-phenyl)acetic acid; 2-(3-{3-[[2-chloro-3-(trifluoromethyl)benzyl](2-phenoxy-2-phenyl-ethyl)amino]propoxy}-phenyl)acetic acid; Benzoic acid 2-[3-(3-carboxymethyl-phenoxy)-{2-chloro-3-(trifluoromethyl)benzyl}propylamino]-1-phenyl ethyl ester; (3-{3-[(2-Acetoxy-2-phenyl-ethyl)-(2-chloro-3-trifluoromethyl-benzyl)-amino]-propoxy}-phenyl)-acetc acid methyl ester; Benzoic acid 2-[3-(3-methoxycarbonylmethyl-phenoxy){2-chloro-3-(trifluoromethyl)benzyl}propylamino]-1-phenyl ethyl ester; (3-{4-[(2-Chloro-3-(trifluoromethyl)benzyl)-(2,2-diphenylethyl)-amino]butyl}phenyl)-acetic acid; (3-{3-[(4-Fluoro-3-methyl-benzyl)-((R)-2-phenyl-propyl)-amino]-propoxy}-phenyl)-acetic acid; (3-{3-[Benzo[1,3]dioxol-5-ylmethyl-((R)-2-phenyl-propyl)-amino]-propoxy}phenyl)-acetic acid; (3-{3-[(4-tert-Butyl-benzyl)-((R)-2-phenyl-propyl)-amino]-propoxy}-phenyl)-acetic acid; (3-{3-[(2,3-Dihydro-benzo[1,4]dioxin-6-ylmethyl)-((R)-2-phenyl-propyl)-amino]-propoxy}-phenyl)-acetic acid; (3-{3-[(4-Methylsulfanyl-benzyl)-((R)-2-phenyl-propyl)-amino]-propoxy}-phenyl)-acetic acid; (3-{3-[((R)-2-Phenyl-propyl)-(2,4,5-trifluoro-benzyl)-amino]-propoxy}-phenyl)-acetic acid; (3-{3-[((R)-2-Phenyl-propyl)-(5-piperidin-1-yl-furan-2-ylmethyl)-amino]-propoxy}-phenyl)-acetic acid; (3-{3-[(4-Isopropyl-benzyl)-((R)-2-phenyl-propyl)-amino]-propoxy}-phenyl)-acetic acid; 2-(3-{3-[(2-Chloro-3-trifluoromethyl-benzyl)-diphenylethyl-amino]-propoxy}-phenyl)-propane-1,3-diol; N-(3-{3-[(2-Chloro-3-trifluoromethyl-benzyl)-2,2-diphenylethyl-amino]-propoxy}-phenyl)-carbamic acid tert-butyl ester; 3-{3-[(2-Chloro-3-trifluoromethyl-benzyl)-2,2-diphenylethylamino]-propoxy}-phenylamine; N-(3-{3-[(2-Chloro-3-trifluoromethyl-benzyl)-2,2-diphenylethyl-amino]-propoxy}-phenyl)-acetamide; Furan-2-carboxylic acid N-(3-{3-[(2-Chloro-3-trifluoromethyl-benzyl)-2,2-diphenylethyl-amino]-propoxy}-phenyl)-amide; N-(3-{3-[(2-Chloro-3-trifluoromethyl-benzyl)-2,2-diphenylethyl-amino]-propoxy}-phenyl)-methanesulfonamide; N-(3-{3-[(2-Chloro-3-trifluoromethyl-benzyl)-2,2-diphenylethyl-amino]-propoxy}-phenyl)-benzenesulfonamide; 1-(2-Chloro-phenyl)-3-(3-{3-[(2-chloro-3-trifluoromethyl-benzyl)-2,2-diphenylethyl-amino]-propoxy}-phenyl)-urea; N-(3-{3-[(2-Chloro-3-trifluoromethyl-benzyl)-2,2-diphenylethyl-amino]-propoxy}-phenyl)-N-methyl-amine; N-(3-{3-[(2-Chloro-3-trifluoromethyl-benzyl)-2,2-diphenylethyl-amino]-propoxy}-phenyl)-N-methyl-acetamide; Furan-2-carboxylic acid N-(3-{3-[(2-Chloro-3-trifluoromethyl-benzyl)-2,2-diphenylethyl-amino]-propoxy}-phenyl)-N-methyl-amide; N-(3-{3-[(2-Chloro-3-trifluoromethyl-benzyl)-2,2-diphenylethyl-amino]-propoxy}-phenyl)-N-methyl-methanesulfonamide; (3-{3-[(2-Chloro-3-trifluoromethyl-benzyl)-2,2-diphenylethyl-amino]-propoxy}-phenyl)-N-methyl-benzenesulfonamide; 3-(2-Chloro-phenyl)-1-(3-{3-[(2-chloro-3-trifluoromethyl-benzyl)-2,2-diphenylethyl-amino]-propoxy}-phenyl)-1-methyl-urea; Benzo[1,3]dioxole-5-carboxylic acid N-(3-{3-[(2-Chloro-3-trifluoromethyl-benzyl)-2,2-diphenylethyl-amino]-propoxy}-phenyl)-N-methyl-amide; 1-(3-{3-[(2-Chloro-3-trifluoromethyl-benzyl)-2,2-diphenylethyl-amino]-propoxy}-phenyl)-3-(3,5-dimethoxy-phenyl)-1-methyl-urea; Propane-1-sulfonic acid (5-{3-[(2-chloro-3-trifluoromethyl-benzyl)-diphenylethyl-amino]-propoxy}-2-methyl-phenyl)-amide; 3-{3-[(2-Chloro-3-trifluoromethyl-benzyl)-diphenylethyl-amino]-propoxy}-2-methyl-phenylamine; 2-Chloro-5-{3-[(2-chloro-3-trifluoromethyl-benzyl)-diphenylethyl-amino]-propoxy}-phenylamine; 3-{3-[(2-Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-amino]-propoxy}-phenyl)-cyclopentyl-amine; (3-{3-[(2-Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-amino]-propoxy}-phenyl)-isopropyl-amine; Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-amino]-propoxy}-phenyl)-ethyl-amine; (3-{3-[(2-Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-amino]-propoxy}-phenyl)-(3-methyl-butyl)-amine; (3-{3-[(2-Chloro-3-trifluoromethyl-benzyl)-diphenylethyl-amino]-propoxy}-phenyl)-isobutyl-amine; (3-{3-[(2-Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-amino]-propoxy}-phenyl)-(2,2,2-trifluoroethyl)-amine; (3-{3-[(2-Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-amino]-propoxy}-phenyl)-cyclopropylmethy-1-amine; (3-{3-[(2-Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-amino]-propoxy}-phenyl)-(2-ethyl-butyl)-amine; (3-{3-[(2-Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-amino]-propoxy}-phenyl)-(2,2-dimethyl-propyl)-amine; (3-{3-[(2-Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-amino]-propoxy}-phenyl)-hexyl-amine; Butyl-(3-{3[(2-chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-amino]-propoxy}-phenyl)-amine; [1-(3-{3-[(2-Chloro-3-(trifluoromethyl)-benzyl)-(2,2-diphenylethyl)-amino]-propoxy}-phenyl-piperidine-4-carboxylic acid; [1-(3-{3-[(2-Chloro-3-(trifluoromethyl)-benzyl)-(2,2-diphenylethyl)-amino]-propoxy}-phenyl-piperidine-4-yl-acetic acid; [4-(3-{3-[(2-Chloro-3-(trifluoromethyl)-benzyl)-(2,2-diphenylethyl-amino]-propoxy}-phenyl)-piperidin-1-yl]-acetic acid; rac-±-(3-{3-[(2-Chloro-3-trifluoromethyl-benzyl)-(trifluoro-phenyl-propyl)-amino]-propoxy}-phenyl)-acetic acid; rac-±-(3-{3-[(2-Chloro-3-trifluoromethyl-benzyl)-(2-dimethylamino-2-phenyl-ethyl)-amino]-propoxy}-phenyl)-acetic acid; rac-±-(3-{3-[(2-Chloro-3-trifluoromethyl-benzyl)-(2-morpholin-4-yl-2-phenyl-ethyl)-amino]-propoxy}-phenyl)-acetic acid; (2-Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-[3-(6-morpholin-4-yl-pyridin-2-yloxy)-propyl]-amine; [3-(6-Chloro-pyridin-2-yloxy)-propyl]-(2-Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-amine; (2-Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-{3-[6-(4-methyl-piperazin-1-yl)-pyridin-2-yloxy]-propyl}-amine; (2-Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-[3-(6-piperazin-1-yl-pyridin-2-yloxy)-propyl]-amine; [4-(6-{3-[(2-Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-amino]-propoxy}-pyridin-2-yl)-piperazin-1-yl]-acetic acid; 2-(3-{3-[[2-Chloro-3-(trifluoromethyl)benzyl]((S)-2-phenyl-propyl)amino]-(R)-1-methyl-propoxy}-phenyl)acetic acid; 2-(3-{3-[[2-Chloro-3-(trifluoromethyl)benzyl]((S)-2-phenyl-propyl)amino]-(R)-1-methyl-propoxy}-phenyl)ethanol; 2-(3-{3-[[2-Chloro-3-(trifluoromethyl)benzyl]((S)-2-phenyl-propyl)amino]-(R)-2-methyl-propoxy}-phenyl)acetic acid; 2-(3-{3-[[2-Chloro-3-(trifluoromethyl)benzyl]((S)-2-phenyl-propyl)amino]-(R)-2-methyl-propoxy}-phenyl)ethanol; 2-(3-{3-[[2-Chloro-3-(trifluoromethyl)benzyl]((R)-2-phenyl-propyl)amino]-(R)-2-methyl-propoxy}-phenyl)acetic acid; 2-(3-{3-[[2-Chloro-3-(trifluoromethyl)benzyl]((R)-2-phenyl-propyl)amino]-(R)-2-methyl-propoxy}-phenyl)ethanol; (R)-2-(3-{3-[[2-Chloro-3-(trifluoromethyl)benzyl](2,2-diphenylethyl)amino]-2-methyl-propoxy}-phenyl)ethanol; 3-{3-[(3-Chloro-2-trifluoromethyl-benzyl)-diphenylethyl-amino]-propoxy-N,N-dimethyl-benzenesulfonamide; Cyclopropanecarboxylic acid 3-{3-[(2-chloro-3-trifluoromethyl-benzyl)-diphenylethyl-amino]-propoxy}-benzylamide; N-(3-{3-[(2-Chloro-3-trifluoromethyl-benzyl)-diphenylethyl-amino]-propoxy}-benzyl)-isobutyramide; Acetic acid (3-{3-[(2-chloro-3-trifluoromethyl-benzyl)-diphenylethyl-amino]-propoxy}-benzylcarbamoyl)-methyl ester; N-(3-{3-[(2-Chloro-3-trifluoromethyl-benzyl)-diphenylethyl-amino]-propoxy}-benzyl)-propionamide; 2,5-Dimethyl-2-H-pyrazole-3-carboxylic acid 3-{3-[(2-chloro-3-trifluoromethyl-benzyl)-diphenylethyl-amino]-propoxy}-benzylamide; (2-Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-(3-o-tolyloxy-propyl)-amine; 2-{3-[(2-Chloro-3-trifluoromethyl-benzyl)-diphenylethyl-amino]-propoxy}-benzonitrile; [3-{3-[(2-Chloro-3-trifluoromethyl-benzyl)-diphenylethyl-amino]-propoxy}benzonitrile; [3-(3-Chloro-phenoxy)-propyl]-(2-chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-amine; (2-Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-[3-(2-methoxy-phenoxy)-propyl]-amine; [3-(2-Chloro-phenoxy)-propyl]-(2-chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-amine; (2-Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-(3-phenoxy-propyl)-amine; (2-Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-[3-(3-isopropyl-phenoxy)-propyl]-amine; (2-Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-[3-(4-methoxy-phenoxy)-propyl]-amine; 3-{3-[(Chloro-trifluoromethyl-benzyl)-diphenylethyl-amino]-propoxy}-phenol; 2-{3-[(Chloro-trifluoromethyl-benzyl)-diphenylethyl-amino]-propoxy}-phenol; 3-{3-[(Chloro-trifluoromethyl-benzyl)-diphenylethyl-amino]-propoxy}-phenylamine; (2-Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-[3-(3-trifluoromethyl-phenoxy)-propyl]-amine; 1-(3-{3-[(Chloro-trifluoromethyl-benzyl)-diphenylethyl-amino]-propoxy}-phenyl)-ethanone; (3-{3-[(2-Chloro-3-trifluoromethyl-benzyl)-diphenylethyl-amino]-propoxy}-phenyl)-phenyl-amine; [3-(Benzo[1,3]dioxol-5-yloxy)-propyl]-(2-chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-amine; (2-Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-(3-m-tolyloxy-propyl)-amine; (2-Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-[3-(3-methoxy-phenoxy)-propyl]-amine; (2-Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-[3-(3-isobutyl-phenoxy)-propyl]-amine; [3-(3-Butyl-phenoxy)-propyl]-(2-chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-amine; (2-Chloro-3-trifluoromethyl-benzyl)-{3-[3-(2,2-dimethyl-propyl)-phenoxy]-propyl}-(2,2-diphenyl-ethyl)-amine; (4-{3-[(2-Chloro-3-trifluoromethyl-benzyl)-diphenylethyl-amino]-propoxy}-benzyl)-methyl-amine; (2-Chloro-3-trifluoromethyl-benzyl)-[3-(4-dimethylaminomethyl-phenoxy)-propyl]-(2,2-diphenyl-ethyl)-amine; (2-Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-[3-(4-morpholin-4-ylmethyl-phenoxy)-propyl]-amine; (2-Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-{3-[4-(4-methyl-piperazin-1-ylmethyl)-phenoxy]-propyl}-amine; (3-{3-[(Chloro-trifluoromethyl-benzyl)-diphenylethyl-amino]-propoxy}-benzyl)-methyl-amine; (2-Chloro-3-trifluoromethyl-benzyl)-[3-(3-dimethylaminomethyl-phenoxy)-propyl]-(2,2-diphenyl-ethyl)-amine; (2-Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-[3-(3-morpholin-4-ylmethyl-phenoxy)-propyl]-amine; (2-Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-{3-[3-(4-methyl-piperazin-1-ylmethyl)-phenoxy]-propyl}-amine; (3-{3-[(2-Chloro-3-trifluoromethyl-benzyl)-diphenylethyl-amino]-propoxy}-benzyl)-isopropyl-amine; {3-[(2-Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl-amino)]-propoxy}-4-trifluoromethyl-phenylamine; {3-[(2-Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl-amino)]-propoxy}-4-methyl-phenylamine; Ethanesulfonic acid (3-{3-[(2-chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl-amino)]-propoxy}-4-methyl-phenyl)-amide; Propane-2-sulfonic acid (3-{3-[(2-chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl-amino)]-propoxy}-4-methyl-phenyl)-amide; Methanesulfonic acid (3-{3-[(2-Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl-amino)]-propoxy}-4-methyl-phenyl)-amide; 2,2,2-Trifluoro-ethanesulfonic acid (3-{3-[(2-Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl-amino)]-propoxy}-4-methyl-phenyl)-amide; Ethanesulfonic acid (3-{3-[(2-Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl-amino)]-propoxy}-phenyl)-amide; 2,2,2-Trifluoro-ethanesulfonic acid (3-{3-[(2-Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl-amino)]-propoxy}-phenyl)-amide; N-(3-{3-[(2-Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl-amino)]-propoxy}-phenyl)-1,1,1-trifluoro-methanesulfonamide; Propane-2-sulfonic acid (3-{3-[(2-Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl-amino)]-propoxy}-phenyl)-amide; {3-[(2-Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl-amino)]-propoxy}-4-methoxy-phenylamine; Ethanesulfonic acid (3-{3-[(2-chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl-amino)]-propoxy}-4-methoxy-phenyl)-amide; (2-Chloro-3-trifluoromethyl-benzyl)-{3-[3-(2-morpholin-4-yl-ethyl)-phenoxy]-propyl}-((S)-2-phenyl-propyl amine; (2-Chloro-3-trifluoromethyl-benzyl)-{3-[3-(2-ethylamino-ethyl)-phenoxy]-propyl}-((S)-2-phenyl-propyl)-amine; (3-{(R)-3-[(2-Chloro-3-trifluoromethyl-benzyl)-((S)-2-phenyl-propyl)-amino]-butoxy}-phenyl)-acetic acid; (3-{(S)-3-[(2-Chloro-3-trifluoromethyl-benzyl)-((S)-2-phenyl-propyl)-amino]-butoxy}-phenyl)-acetic acid; 2-(3-{3-[(2-Chloro-3-trifluoromethyl-benzyl)-((S)-2-phenyl-propyl)-amino]-propoxy}-phenyl)-ethanol; 2-(3-{3-[(2-Chloro-3-trifluoromethyl-benzyl)-((S)-2-phenyl-propyl)-amino]-propoxy}-phenyl)-2-methyl-propionic acid; 2-(3-{3-[(2-Chloro-3-trifluoromethyl-benzyl)-((R)-2-phenyl-propyl)-amino]-propoxy}-phenyl)-2-methyl-propionic acid; (3-{3-[(2-Chloro-3-trifluoromethyl-benzyl)-(2-thiophen-3-yl-propyl)-amino]-propoxy}-phenyl)-acetic acid; 2-(3-{3-[(2-Chloro-3-trifluoromethyl-benzyl)-(2-thiophen-3-yl-propyl)-amino]-propoxy}-phenyl)-ethanol; (3-{3-[(2-Chloro-3-trifluoromethyl-benzyl)-(2-thiophen-2-yl-propyl)-amino]-propoxy}-phenyl)-acetic acid; (3-{3-[(2-Chloro-3-trifluoromethyl-benzyl)-(2-pyridin-2-yl-propyl)-amino]-propoxy}-phenyl)-acetic acid; [3-(3-{(2-Chloro-3-trifluoromethyl-benzyl)-[2-(4-methyl-pyridin-2-yl)-propyl]-amino}-propoxy)-phenyl]-acetic acid; [3-(3-{(2-Chloro-3-trifluoromethyl-benzyl)-[3,3,3-trifluoro-2-(1H-pyrrol-2-yl)-propyl]-amino}-propoxy)-phenyl]-acetic acid; (2-Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-(3-{3-[2-(4-methyl-piperazin-1-yl)-ethyl]-phenoxy}-propyl)-amine; (2-Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-{3-[3-(2-methylamino-ethyl)-phenoxy]-propyl}-amine; (2-Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-[3-(3-{2-[(1H-imidazol-2-ylmethyl)-amino]-ethyl}-phenoxy)-propyl]-amine; (2-Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-{3-[3-(2-ethylamino-ethyl)-phenoxy]-propyl}-amine; [3-(3-{2-[(5-Bromo-thiophen-2-ylmethyl)-amino]-ethyl}-phenoxy)-propyl]-(2-chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-amine; (2-Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-[3-(3-{2-[(thiophen-2-ylmethyl)-amino]-ethyl}-phenoxy)-propyl]-amine; (2-Chloro-3-trifluoromethyl-benzyl)-{3-[3-(2-dimethylamino-ethyl)-phenoxy]-propyl}-(2,2-diphenyl-ethyl)-amine; (2-Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-{3-[3-(2-pyrrolidin-1-yl-ethyl)-phenoxy]-propyl}-amine; (2-Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-{3-[3-(2-morpholin-4-yl-ethyl)-phenoxy]-propyl}-amine; (2-Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-{(R)-1-methyl-3-[3-(2-morpholin-4-yl-ethyl)-phenoxy]-propyl}-amine; (2-Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-{(R)-2-methyl-3-[3-(2-morpholin-4-yl-ethyl)-phenoxy]-propyl}-amine; {3-[3-(2-Amino-ethyl)-phenoxy]-propyl}-(2-chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-amine; [2-(3-{3-[(2-chloro-3-trifluoromethyl-benzyl)-diphenylethyl-amino]-propoxy}-phenyl)-ethyl]-isopropyl-amine; [2-(3-{3-[(2-chloro-3-trifluoromethyl-benzyl)-diphenylethyl-amino]-propoxy}-phenyl)-ethyl]-propyl-amine; 2-[2-(3-{3-[(2-chloro-3-trifluoromethyl-benzyl)-diphenylethyl-amino]-propoxy}-phenyl)-ethylamino]-ethanol; (2-Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-[3-(3-{2-[(1-methyl-1H-imidazol-2-ylmethyl)-amino]-ethyl}-phenoxy)-propyl]-amine; (2-Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-{3-[3-(2-thiomorpholin-4-yl-ethyl)-phenoxy]-propyl}-amine; [2-(3-{3-[(2-chloro-3-trifluoromethyl-benzyl)-diphenylethyl-amino]-propoxy}-phenyl)-ethylamino]-acetic acid; [2-(3-{(R)-3-[(2-chloro-3-trifluoromethyl-benzyl)-diphenylethyl-amino]-butoxy}-phenyl)-ethylamino]-acetic acid; {[2-(3-{3-[(2-chloro-3-trifluoromethyl-benzyl)-diphenylethyl-amino]-propoxy}-phenyl)-ethyl]-methyl-amino}-acetic acid; 2-[2-(3-{3-[(2-chloro-3-trifluoromethyl-benzyl)-diphenylethyl-amino]-propoxy}-phenyl)-ethylamino]-2-methyl-propionic acid; (S)-2-[2-(3-{3-[(2-chloro-3-trifluoromethyl-benzyl)-diphenylethyl-amino]-propoxy}-phenyl)-ethylamino]-propionic acid; (R)-1-[2-(3-{3-[(2-chloro-3-trifluoromethyl-benzyl)-diphenylethyl-amino]-propoxy}-phenyl)-ethyl]-pyrrolidine-2-carboxylic acid; (S)-1-[2-(3-{3-[(2-chloro-3-trifluoromethyl-benzyl)-diphenylethyl-amino]-propoxy}-phenyl)-ethyl]-pyrrolidine-2-carboxylic acid; [2-(3-{3-[(2-chloro-3-trifluoromethyl-benzyl)-diphenylethyl-amino]-propoxy}-phenyl)-ethyl]-pyrimidin-2-yl-amine; (2-Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-[3-(3-morpholin-4-yl-phenoxy)-propyl]-amine; (2-Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-[3-(3-piperidin-1-yl-phenoxy)-propyl]-amine; (3-{3-[(2-chloro-3-trifluoromethyl-benzyl)-diphenylethyl-amino]-propoxy}-phenyl)-diethyl-amine; (2-Chloro-3-trifluoromethyl-benzyl)-{3-[3-(2,5-dimethyl-pyrrol-1-yl)-phenoxy]-propyl}-(2,2-diphenyl-ethyl)-amine; (2-Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-[3-(3-piperazin-1-yl-phenoxy)-propyl]-amine; (2-Chloro-3-trifluoromethyl-benzyl)-((S)-2-phenyl-propyl)-[3-(3-piperazin-1-yl-phenoxy)-propyl]-amine; (2-Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-[(R)-2-methyl-3-(3-piperazin-1-yl-phenoxy)-propyl]-amine; [4-(3-{3-[(2-chloro-3-trifluoromethyl-benzyl)-diphenylethyl-amino]-propoxy}-phenyl)-piperazin-1-yl]-acetic acid; [4-(3-{3-[(2-chloro-3-trifluoromethyl-benzyl)-((S)-2-phenyl-propyl)-amino]-propoxy}-phenyl)-piperazin-1-yl]-acetic acid; [4-(3-((R)-[(2-chloro-3-trifluoromethyl-benzyl)-diphenylethyl-amino]-methyl-propoxy}-phenyl)-piperazin-1-yl]-acetic acid; (2-Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-{3-[3-(4-methyl-piperazin-1-yl)-phenoxy]-propyl}-amine; (2-Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-[3-(3-pyrrolidin-1-yl-phenoxy)-propyl]-amine; (3-{3-[(2-chloro-3-trifluoromethyl-benzyl)-diphenylethyl-amino]-propoxy}-phenylamino)-acetic acid; [(3-{3-[(2-chloro-3-trifluoromethyl-benzyl)-diphenylethyl-amino]-propoxy}-phenyl)-N-methyl-amino]-acetic acid; N-(2,2-Diphenylethyl)-N-(2-chloro-3-trifluoromethylbenzyl)-3-[3-(2-methyl-2-aminopropyl)phenoxy]propylamine; N-(2,2-Diphenylethyl)-N-(2-chloro-3-trifluoromethylbenzyl)-3-(3-[2-hydroxymethyl]phenoxy)propylamine, N-(2,2-Diphenylethyl)-N-(2-chloro-3-trifluoromethylbenzyl)-3-(3-[2-hydroxy-2-methylpropyl]phenoxy)propylamine; N-(2,2-Diphenylethyl)-N-(2-chloro-3-trifluoromethylbenzyl)-3-(3-N-methylsulfonamidophenoxy)propylamine; N-(2-[2-Chlorophenyl]-propyl)-N-(2-chloro-3-trifluoromethylbenzyl)-3-(3-carboxymethylenephenoxy)propylamine; N-(2-[3-Chlorophenyl]-propyl)-N-(2-chloro-3-trifluoromethylbenzyl)-3-(3-carboxymethylenephenoxy)propylamine; N-(2-[4-Chlorophenyl]-propyl)-N-(2-chloro-3-trifluoromethylbenzyl)-3-(3-carboxymethylenephenoxy)propylamine; N-(2-[2-Methoxyphenyl]-propyl)-N-(2-chloro-3-trifluoromethylbenzyl)-3-(3-carboxymethylenephenoxy)propylamine; N-(2-[4-Methoxyphenyl]-propyl)-N-(2-chloro-3-trifluoromethylbenzyl)-3-(3-carboxymethylenephenoxy)propylamine; N-(2-Phenyl-4-methylpentyl)-N-(2-chloro-3-trifluoromethylbenzyl)-3-(3-carboxymethylenephenoxy)propylamine; N-(2-Phenylbutyl)-N-(2-chloro-3-trifluoromethylbenzyl)-3-(3-carboxymethylenephenoxy)propylamine; N-(2-[2-Methyl-2-phenyl]propyl)-N-(2-chloro-3-trifluoromethylbenzyl)-3-(3-carboxymethylenephenoxy)propylamine; N-(2-Phenyl-3-methylbutyl)-N-(2-chloro-3-trifluoromethylbenzyl)-3-(3-carboxymethylenephenoxy)propylamine; N-(2-Phenylhexyl)-N-(2-chloro-3-trifluoromethylbenzyl)-3-(3-carboxymethylenephenoxy)propylamine; N-(2-Phenyl-3-butynyl)-N-(2-chloro-3-trifluoromethylbenzyl)-3-(3-carboxymethylenephenoxy)propylamine; (S)-N-(2-Phenyl-2-methoxyethyl)-N-(2-chloro-3-trifluoromethylbenzyl)-3-(3-carboxymethylenephenoxy)propylamine; (R)-N-(2-Phenyl-2-methoxyethyl)-N-(2-chloro-3-trifluoromethylbenzyl)-3-(3-carboxymethylenephenoxy)propylamine; (R)-N-(2-Phenyl-2-methoxyethyl)-N-2-chloro-3-trifluoromethylbenzyl)-3-(3-[2-hydroxy-2-methylpropyl]phenoxy)propylamine; 1-(3-{3-[(2-Chloro-3-trifluoromethyl-benzyl)-diphenylethyl-amino]-propoxy}-phenyl)-cyclobutanecarboxylic acid; 1-(3-{3-[(2-Chloro-3-trifluoromethyl-benzyl)-diphenylethyl-amino]-propoxy}-phenyl)-cyclopentanecarboxylic acid; 1-(3-{3-[(2-Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-amino]-propoxy}-phenyl)-cyclopropanecarboxylic acid;

and a pharmaceutically acceptable salt or hydrate thereof.

21. The compound according to claim 1 , selected from:

2-(3-{3-[[2-chloro-3-(trifluoromethyl)benzyl](2,2-dephenylethyl)amino]propoxy}phenyl)-ethanol,

(2-chloro-3-trifluoromethyl-benzyl)-(2,2-diphenylethyl)-{3-[3-(1,2,4-triazol-3-ylmethyl)-phenoxy]-propyl}-amine,

(2-chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-{3-[3-(1,2,3,4-tetrazol-5-ylmethyl)-phenoxy]-propyl}-amine,

(2-chloro-3-trifluoromethyl-benzyl)-(2-cyclohexyl-2-phenyl-ethyl)-{3-[3-(1,2,3,4-tetrazol-5-ylmethyl)-phenoxy]-propyl}-amine,

2-(3-{3-[[2-chloro-3-(trifluoromethyl)benzyl]-benzylamino]propoxy}-phenyl)acetic acid,

2-(3-{3-[[2-chloro-3-(trifluoromethyl)-benzyl]phenethylamino]propoxy}-phenyl)acetic acid,

2-(3-{3-[[2-chloro-3-(trifluoromethyl)benzyl](2-hydroxy-2-phenyl-ethyl)amino]propoxy}-phenyl)acetic acid,

2-(3-{3-[[2-chloro-3-(trifluoromethyl)benzyl](2-acetoxy-2-phenyl-ethyl)amino]propoxy}-phenyl)acetic acid,

2-(3-{3-[[2-chloro-3-(trifluoromethyl)benzyl](2-phenoxy-2-phenyl-ethyl)amino]propoxy}-phenyl)acetic acid,

(3-{3-[(2-acetoxy-2-phenylethyl)(2-chloro-3-trifluoromethyl-benzyl)-amino]-propoxy}-phenyl)-acetic acid methyl ester,

benzoic acid 2-[3-(3-methoxycarbonylmethyl-phenoxy){2-chloro-3-(trifluoromethyl)benzyl}propylamino]-1-phenyl ethyl ester,

(3-{4-(2-chloro-3-trifluoromethyl)benzyl)-(2,2-diphenylethyl)-amino]butyl}phenyl)-acetic acid,

furan-2-carboxylic acid N-(3-{3-[(2-Chloro-3-trifluoromethyl-benzyl)-2,2-diphenylethyl-amino]-propoxy}-phenyl)-amide,

1-(3-{3-[(2-chloro-3-trifluoromethyl-benzyl)-diphenylethyl-amino]-propoxy}-phenyl)-cyclobutanecarboxylic acid,

N-(2,2-diphenylethyl)-N-(2-chloro-3-trifluoromethylbenzyl)-3-(3-[2-hydroxy-2-methylpropyl]phenoxy)propylamine,

(2-chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-[3-(3-{2-[(1H-imidazol-2-ylmethyl)-amino]-ethyl}-phenoxy)-propyl]-amine,

N-(3-{3-[(2-chloro-3-trifluoromethyl-benzyl)-2,2-diphenylethyl-amino]-propoxy}-phenyl)-methanesulfonamide,

N-(3-{3-[(2-chloro-3-trifluoromethyl-benzyl)-2,2-diphenylethyl-amino]-propoxy}-phenyl)-N-methyl-amine,

[2-(3-{3-[(2-chloro-3-trifluoromethyl-benzyl)-diphenylethyl-amino]-propoxy}-phenyl)-ethylamino]-acetic acid,

N-(2-[3-chlorophenyl]-propyl)-N-(2-chloro-3-trifluoromethylbenzyl)-3-(3-carboxymethylenephenoxy)propylamine,

[4-(3-{3-[(2-chloro-3-trifluoromethyl-benzyl)-diphenylethyl-amino]-propoxy}-phenyl)-piperazin-1-yl]-acetic acid,

(2-chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-{3-[3-(4-methyl-piperazin-1-yl)-phenoxy]-propyl}-amine,

[1-(3-{3-[(2-chloro-3-(trifluoromethyl)-benzyl)-(2,2-diphenylethyl)-amino]-propoxy}-phenyl-piperidine-4-carboxylic acid,

and a pharmaceutically acceptable salt or hydrate thereof.

22. The compound according to claim 1 , selected from:

(S)-(2-chloro-3-trifluoromethyl-benzyl)-(2-phenyl-propyl)-{3-[3-(1,2,3,4-tetrazol-3-ylmethyl)-phenoxy]-propyl}-amine,

(R)-(2-chloro-3-trifluoromethyl-benzyl)-(2-phenyl-propyl)-{3-[3-(1,2,3,4-tetrazol-3-ylmethyl)-phenoxy]-propyl}-amine,

(S)-2-(3-{3-[[2-chloro-3-(trifluoromethyl)benzyl](2-phenyl-propyl)amino]propoxy}-phenyl)acetic acid,

(R)-2-(3-{3-[[2-chloro-3-(trifluoromethyl)benzyl](2-phenyl-propyl)amino]propoxy}-phenyl)acetic acid,

(R)-1-[2-(3-{3-[(2-chloro-3-trifluoromethyl-benzyl)-diphenylethyl-amino]-propoxy}-phenyl)-ethyl]-pyrrolidine-2-carboxylic acid,

(2-chloro-3-trifluoromethyl-benzyl)-{3-[3-(2-morpholin-4-yl-ethyl)-phenoxy]-propyl}-((S)-2-phenyl-propyl amine,

2-(3-{3-[(2-chloro-3-trifluoromethyl-benzyl)-((S)-2-phenyl-propyl)-amino]-propoxy}-phenyl)-2-methyl-propionic acid,

(3-{(R)-3-[(2-chloro-3-trifluoromethyl-benzyl)-((S)-2-phenyl-propyl)-amino]-butoxy}-phenyl)-acetic acid,

[4-(3-{3-[(2-chloro-3-trifluoromethyl-benzyl)-((S)-2-phenyl-propyl)-amino]-propoxy}-phenyl)-piperazin-1-yl]-acetic acid,

[4-(3-{(R)-[(2-chloro-3-trifluoromethyl-benzyl)-diphenylethyl-amino]-methyl-propoxy}-phenyl)-piperazin-1-yl]-acetic acid,

and a pharmaceutically acceptable salt or hydrate thereof.

23. A pharmaceutical composition comprising a compound according to claim 1 and a pharmaceutically acceptable carrier or diluent.

24. A method for the prevention or treatment of an LXR mediated disease or condition, wherein said disease or condition is selected from atherosclerosis and inflammation, comprising administering a therapeutically effective amount of the compound according to claim 1 .

25. The method according to claim 24 , comprising administering a therapeutically effective amount of the compound according to claim 3 .

26. The method according to claim 24 , comprising administering a therapeutically effective amount of the compound according to claim 7 .

27. The method according to claim 24 , comprising administering a therapeutically effective amount of the compound according to claim 8 .

28. The method according to claim 24 , comprising administering a therapeutically effective amount of the compound according to claim 9 .

29. The method according to claim 24 , comprising administering a therapeutically effective amount of the compound according to claim 11 .

30. The method according to claim 24 , comprising administering a therapeutically effective amount of the compound according to claim 14 .

31. The method according to claim 24 , comprising administering a therapeutically effective amount of the compound according to claim 15 .

32. The method according to claim 24 , comprising administering a therapeutically effective amount of the compound according to claim 17 .

33. The method according to claim 24 , comprising administering a therapeutically effective amount of the compound according to claim 18 .

34. The method according to claim 27 , comprising administering a compound selected from:

2-(3-{3-[[2-chloro-3-(trifluoromethyl)benzyl](2,2-dephenylethyl)amino]propoxy}phenyl)-ethanol,

(2-chloro-3-trifluoromethyl-benzyl)-(2,2-diphenylethyl){3-[3-(1,2,4-triazol-3-ylmethyl)-phenoxy]-propyl}-amine,

(2-chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-{3-[3-(1,2,3,4-tetrazol-5-ylmethyl)-phenoxy]-propyl}-amine,

(S)-(2-chloro-3-trifluoromethyl-benzyl)-(2-phenyl-propyl)-{3-[3-(1,2,3,4-tetrazol-3-ylmethyl)-phenoxy]-propyl}-amine,

(R)-(2-chloro-3-trifluoromethyl-benzyl)-(2-phenyl-propyl)-{3-[3-(1,2,3,4-tetrazol-3-ylmethyl)-phenoxy]-propyl}-amine,

(S-)-2-(3-{3-[[2-chloro-3-(trifluoromethyl)benzyl](2-phenyl-propyl)amino]-propoxy}-phenyl)acetic acid,

(R-)-2-(3-{3-[[2-chloro-3-(trifluoromethyl)benzyl](2-phenyl-propyl)amino]-propoxy}-phenyl)acetic acid,

2-(3-{3-[[2-chloro-3-(trifluoromethyl)benzyl](2-acetoxy-2-phenyl-ethyl)amino]propoxy}-phenyl)acetic acid,

(3-{3-[(2-acetoxy-2-phenyl-ethyl)-(2-chloro-3-trifluoromethyl-benzyl)-amino]-propoxy}-phenyl)-acetic acid methyl ester,

(3-{4-[(2-chloro-3-(trifluoromethyl)benzyl)-(2,2-diphenylethyl)-amino]butyl}phenyl)-acetic acid,

1-(3-{3-[(2-chloro-3-trifluoromethyl-benzyl)-diphenylethyl-amino]-propoxy}-phenyl)-cyclobutanecarboxylic acid,

N-(2,2-diphenylethyl)-N-(2-chloro-3-trifluoromethylbenzyl)-3-(3-[2-hydroxy-2-methylpropyl]phenoxy)propylamine,

(2-chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-[3-(3-{2-[(1H-imidazol-2-ylmethyl)-amino]-ethyl}-phenoxy)-propyl]-amine,

N-(3-{3-[(2-chloro-3-trifluoromethyl-benzyl)-2,2-diphenylethyl-amino]-propoxy}-phenyl)-methanesulfonamide,

N-(3-{3-[(2-chloro-3-trifluoromethyl-benzyl)-2,2-diphenylethyl-amino]-propoxy}-phenyl)-N-methyl-amine,

[2-(3-{3-[(2-chloro-3-trifluoromethyl-benzyl)-diphenylethyl-amino]-propoxy}-phenyl)-ethylamino]-acetic acid,

(R)-1-[2-(3-{3-[(2-chloro-3-trifluoromethyl-benzyl)-diphenylethyl-amino]-propoxy}-phenyl)-ethyl]-pyrrolidine-2-carboxylic acid,

furan-2-carboxylic acid N-(3-{3-[(2-chloro-3-trifluoromethyl-benzyl)-2,2-diphenylethyl-amino]-propoxy}-phenyl)-amide,

N-(2-[3-chlorophenyl]-propyl)-N-(2-chloro-3-trifluoromethylbenzyl)-3-(3-carboxymethylenephenoxy)propylamine,

(2-chloro-3-trifluoromethyl-benzyl)-{3-[3-(2-morpholin-4-yl-ethyl)-phenoxy]-propyl}-((S)-2-phenyl-propyl amine,

[4-(3-{3-[(2-chloro-3-trifluoromethyl-benzyl)-diphenylethyl-amino]-propoxy}phenyl)-piperazin-1-yl]-acetic acid,

2-(3-{3-[(2-chloro-3-trifluoromethyl-benzyl)-((S)-2-phenyl-propyl)-amino]-propoxy}-phenyl)-2-methyl-propionic acid,

(2-chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl){3-[3-(4-methyl-piperazin-1-yl)-phenoxy]-propyl}-amine,

(3-{(R)-3-[(2-chloro-3-trifluoromethyl-benzyl)-((S)-2-phenyl-propyl)-amino]-butoxy}-phenyl)-acetic acid,

[1-(3-{3-[(2-chloro-3-(trifluoromethyl)-benzyl)-(2,2-diphenylethyl)-amino]-propoxy}-phenyl-piperidine-4-carboxylic acid,

[4-(3-{3-[(2-chloro-3-trifluoromethyl-benzyl)-((S)-2-phenyl-propyl)-amino]-propoxy}-phenyl)-piperazin-1-yl]-acetic acid,

[4-(3-{(R)-[(2-chloro-3-trifluoromethyl-benzyl)-diphenylethyl-amino]-methyl-propoxy}-phenyl)-piperazin-1-yl]-acetic acid,

and a pharmaceutically acceptable salt or hydrate thereof.

35. A method for increasing reverse cholesterol transport, said method comprising administering a therapeutically effective amount of the compound according to claim 1 .

36. A method for inhibiting cholesterol absorption, said method comprising administering a therapeutically effective amount of the compound according to claim 1 .