IP Library › Granted Patent US 7,335,350
Granted Patent B2
US 7,335,350 · App. 10/510,014 · Granted Feb 26, 2008

Chemokines mutants having improved oral bioavailability

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Quick Facts
Patent No.
US 7,335,350
App. No.
10/510,014
Granted
Feb 26, 2008
Kind
B2
Abstract

The oral efficacy of C—C chemokines containing a dibasic site in the 40's conserved cationic sequence, such as RANTES and MIP-1β, is improved by substituting at least one of the residues in the dibasic site in a non-conservative manner.

Claims (3)

1. A method of treating multiple sclerosis comprising orally administering, to an individual, a composition comprising a pharmaceutically acceptable excipient and a RANTES polypeptide comprising SEQ ID NO:1 or amino acids 1-68 of SEQ ID NO: 1 in an amount effective to treat said individual.

2. The method of claim 1 , wherein said RANTES polypeptide comprises SEQ ID NO: 1.

3. The method of claim 1 , wherein said RANTES polypeptide comprises amino acids 1-68 of SEQ ID NO:1.

Assignments (3)
CHANGE OF NAME Recorded Dec 3, 2009
From: LABORATOIRES SERONO SA
To: MERCK SERONO SA
Reel/Frame 023601/0156 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 11, 2007
From: APPLIED RESEARCH SYSTEMS ARS HOLDING N.V.
To: LABORATOIRES SERONO SA
Reel/Frame 019966/0026 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 8, 2005
From: PROUDFOOT, AMANDA; KOSCO-VILBOIS, MARIE; WELLS, TIMOTHY
To: APPLIED RESEARCH SYSTEMS ARS HOLDING N.V.
Reel/Frame 016039/0762 →