IP Library › Granted Patent US 7,223,738

Granted Patent B2

US 7,223,738 · App. 10/510,069 · Granted May 29, 2007

Inhibitors of Akt activity

View Patent ↗

Loading inventors, assignments & file history…

Monitor This Case

Get email alerts when status or documents change.

Order Certified Copies

Most orders are placed with the USPTO same day — all within 24 business hours.

Order via The Patent Place →

Pre-filled with this patent's details

Quick Facts

Patent No.: US 7,223,738
App. No.: 10/510,069
Granted: May 29, 2007
Kind: B2

External Links

USPTO Patent Center↗ Full Patent PDF↗

Abstract

The present invention is directed to compounds comprising a 2,3-diphenylquinoxaline moiety which inhibit the activity of Akt, a serine/threonine protein kinase. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for treating cancer comprising administration of the compounds of the invention.

Claims (876)

1. The compound of the Formula A-1:

wherein:

a is 0 or 1;

b is 0 or 1;

m is 0, 1 or 2;

n is 0, 1, 2 or 3;

p is 0, 1 or 2;

r is 0 or 1;

s is 0 or 1;

u, v, w and x are independently selected from: CH and N, provided that only one of u, v, w and x may be N;

Q is selected from: —NR 5 R 6 and heterocycle, said heterocycle which is optionally substituted with one to three R z ;

R 1 is independently selected from:

1) (C═O) a O b C 1 –C 10 alkyl,

2) (C═O) a O b aryl,

3) C 2 –C 10 alkenyl,

4) C 2 –C 10 alkynyl,

5) (C═O) a O b heterocyclyl,

6) (C═O) a O b C 3 –C 8 cycloalkyl,

7) CO 2 H,

8) halo,

9) CN,

10) OH,

11) O b C 1 –C 6 perfluoroalkyl,

12) O a (C═O) b NR 5 R 6 ,

13) NR c (C═O)NR 5 R 6 ,

14) S(O) m R a ,

15) S(O) 2 NR 5 R 6 ,

16) NR c S(O) m R a ,

17) oxo,

18) CHO,

19) NO 2 ,

20) NR c (C═O)O b R a ,

21) O(C═O)O b C 1 –C 10 alkyl,

22) O(C═O)O b C 3 –C 8 cycloalkyl,

23) O(C═O)O b aryl, and

24) O(C═O)O b -heterocycle,

said alkyl, aryl, alkenyl, alkynyl, heterocyclyl, and cycloalkyl optionally substituted with one or more substituents selected from R z ;

R 2 is independently selected from:

1) (C═O) a O b C 1 –C 10 alkyl,

2) (C═O) a O b aryl,

3) C 2 –C 10 alkenyl,

4) C 2 –C 10 alkynyl,

5) (C═O) a O b heterocyclyl,

6) (C═O) a O b C 3 –C 8 cycloalkyl,

7) CO 2 H,

8) halo,

9) CN,

10) OH,

11) O b C 1 –C 6 perfluoroalkyl,

12) O a (C═O) b NR 5 R 6 ,

13) NR 5 (C═O)NR 5 R 6 ,

14) S(O) m R a ,

15) S(O) 2 NR 5 R 6 ,

16) NR 5 S(O) m R a ,

17) CHO,

18) NO 2 ,

19) NR c (C═O)O b R a ,

20) O(C═O)O b C 1 –C 10 alkyl,

21) O(C═O)O b C 3 –C 8 cycloalkyl,

22) O(C═O)O b aryl, and

23) O(C═O)O b -heterocycle,

said alkyl, aryl, alkenyl, alkynyl, heterocyclyl, and cycloalkyl optionally substituted with one, two or three substituents selected from R z ;

R 5 and R 6 are independently selected from:

1) H,

2) (C═O)O b R a ,

3) C 1 –C 10 alkyl,

4) aryl,

5) C 2 –C 10 alkenyl,

6) C 2 –C 10 alkynyl,

7) heterocyclyl,

8) C 3 –C 8 cycloalkyl,

9) SO 2 R a , and

10) (C═O)NR b 2 ,

said alkyl, cycloalkyl, aryl, heterocylyl, alkenyl, and alkynyl is optionally substituted with one or more substituents selected from R z , or

R 5 and R 6 can be taken together with the nitrogen to which they are attached to form a monocyclic or bicyclic heterocycle with 5–7 members in each ring and optionally containing, in addition to the nitrogen, one or two additional heteroatoms selected from N, O and S, said monocyclic or bicyclic heterocycle optionally substituted with one or more substituents selected from R z ;

R z is selected from:

1) (C═O) r O s (C 1 –C 10 )alkyl,

2) O r (C 1 –C 3 )perfluoroalkyl,

3) (C 0 –C 6 )alkylene-S(O) m R a ,

4) oxo,

5) OH,

6) halo,

7) CN,

8) (C═O) r O s (C 2 –C 10 )alkenyl,

9) (C═O) r O s (C 2 –C 10 )alkynyl,

10) (C═O) r O s (C 3 –C 6 )cycloalkyl,

11) (C═O) r O s (C 0 –C 6 )alkylene-aryl,

12) (C═O) r O s (C 0 –C 6 )alkylene-heterocyclyl,

13) (C═O) r O s (C 0 –C 6 )alkylene-N(R b ) 2 ,

14) C(O)R a ,

15) (C 0 –C 6 )alkylene-CO 2 R a ,

16) C(O)H,

17) (C 0 –C 6 )alkylene-CO 2 H,

18) C(O)N(R b ) 2 ,

19) S(O) m R a ,

20) S(O) 2 N(R b ) 2 ,

21) NR c (C═O)O b R a ,

22) O(C═O)O b C 1 –C 10 alkyl,

23) O(C═O)O b C 3 –C 8 cycloalkyl,

24) O(C═O)O b aryl, and

25) O(C═O)O b -heterocycle,

said alkyl, alkenyl, alkynyl, cycloalkyl, aryl, and heterocyclyl is optionally substituted with up to three substituents selected from R b , OH, (C 1 –C 6 )alkoxy, halogen, CO 2 H, CN, O(C═O)C 1 –C 6 alkyl, oxo, and N(R b ) 2 ;

R a is substituted or unsubstituted (C 1 –C 6 )alkyl, substituted or unsubstituted (C 2 –C 6 )alkenyl, substituted or unsubstituted (C 2 –C 6 )alkynyl, substituted or unsubstituted (C 3 –C 6 )cycloalkyl, substituted or unsubstituted aryl, (C 1 –C 6 )perfluoroalkyl, 2,2,2-trifluoroethyl, or substituted or unsubstituted heterocyclyl; and

R b is H, (C 1 –C 6 )alkyl, substituted or unsubstituted aryl, substituted or unsubstituted benzyl, substituted or unsubstituted heterocyclyl, (C 3 –C 6 )cycloalkyl, (C═O)OC 1 –C 6 alkyl, (C═O)C 1 –C 6 alkyl or S(O) 2 R a ;

R c is selected from:

1) H,

2) C 1 –C 10 alkyl,

3) aryl,

4) C 2 –C 10 alkenyl,

5) C 2 –C 10 alkynyl,

6) heterocyclyl,

7) C 3 –C 8 cycloalkyl,

8) C 1 –C 6 perfluoroalkyl,

said alkyl, cycloalkyl, aryl, heterocylyl, alkenyl, and alkynyl is optionally substituted with one or more substituents selected from R z , or

or a pharmaceutically acceptable salt or a stereoisomer thereof.

2. The compound of the Formula B:

wherein:

a is 0 or 1;

b is 0 or 1;

m is 0, 1 or 2;

n is 0, 1, 2 or 3;

p is 0, 1 or 2;

r is 0 or 1;

s is 0 or 1;

u, v, w and x are independently selected from: CH and N, provided that only one of u, v, w and x may be N;

Q is selected from: —NR 5 R 6 and heterocycle, said heterocycle which is optionally substituted with one to three R z ;

R 1 is independently selected from:

1) (C═O) a O b C 1 –C 10 alkyl,

2) (C═O) a O b aryl,

3) C 2 –C 10 alkenyl,

4) C 2 –C 10 alkynyl,

5) (C═O) a O b heterocyclyl,

6) (C═O) a O b C 3 –C 8 cycloalkyl,

7) CO 2 H,

8) halo,

9) CN,

10) OH,

11) O b C 1 –C 6 perfluoroalkyl,

12) O a (C═O) b NR 5 R 6 ,

13) NR c (C═O)NR 5 R 6 ,

14) S(O) m R a ,

15) S(O) 2 NR 5 R 6 ,

16) NR c S(O) m R a ,

17) oxo,

18) CHO,

19) NO 2 ,

20) NR c (C═O)O b R a ,

21) O(C═O)O b C 1 –C 10 alkyl,

22) O(C═O)O b C 3 –C 8 cycloalkyl,

23) O(C═O)O b aryl, and

24) O(C═O)O b -heterocycle,

said alkyl, aryl, alkenyl, alkynyl, heterocyclyl, and cycloalkyl optionally substituted with one or more substituents selected from R z ;

R 2 is independently selected from:

1) (C═O) a O b C 1 –C 10 alkyl,

2) (C═O) a O b aryl,

3) C 2 –C 10 alkenyl,

4) C 2 –C 10 alkynyl,

5) (C═O) a O b heterocyclyl,

6) (C═O) a O b C 3 –C 8 cycloalkyl,

7) CO 2 H,

8) halo,

9) CN,

10) OH,

11) O b C 1 –C 6 perfluoroalkyl,

12) O a (C═O) b NR 5 R 6 ,

13) NR 5 (C═O)NR 5 R 6 ,

14) S(O) m R a ,

15) S(O) 2 NR 5 R 6 ,

16) NR 5 S(O) m R a ,

17) CHO,

18) NO 2 ,

19) NR c (C═O)O b R a ,

20) O(C═O)O b C 1 –C 10 alkyl,

21) O(C═O)O b C 3 –C 8 cycloalkyl,

22) O(C═O)O b aryl, and

23) O(C═O)O b -heterocycle,

said alkyl, aryl, alkenyl, alkynyl, heterocyclyl, and cycloalkyl optionally substituted with one, two or three substituents selected from R z ;

R 5 and R 6 are independently selected from:

1) H,

2) (C═O)O b R a ,

3) C 1 –C 10 alkyl,

4) aryl,

5) C 2 –C 10 alkenyl,

6) C 2 –C 10 alkynyl,

7) heterocyclyl,

8) C 3 –C 8 cycloalkyl,

9) SO 2 R a , and

10) (C═O)NR b 2 ,

said alkyl, cycloalkyl, aryl, heterocylyl, alkenyl, and alkynyl is optionally substituted with one or more substituents selected from R z , or

R z is selected from:

1) (C═O) r O s (C 1 –C 10 )alkyl,

2) O r (C 1 –C 3 )perfluoroalkyl,

3) (C 0 –C 6 )alkylene-S(O) m R a ,

4) oxo,

5) OH,

6) halo,

7) CN,

8) (C═O) r O s (C 2 –C 10 )alkenyl,

9) (C═O) r O s (C 2 –C 10 )alkynyl,

10) (C═O) r O s (C 3 –C 6 )cycloalkyl,

11) (C═O) r O s (C 0 –C 6 )alkylene-aryl,

12) (C═O) r O s (C 0 –C 6 )alkylene-heterocyclyl,

13) (C═O) r O s (C 0 –C 6 )alkylene-N(R b ) 2 ,

14) C(O)R a ,

15) (C 0 –C 6 )alkylene-CO 2 R a ,

16) C(O)H,

17) (C 0 –C 6 )alkylene-CO 2 H,

18) C(O)N(R b ) 2 ,

19) S(O) m R a ,

20) S(O) 2 N(R b ) 2 ,

21) NR c (C═O)O b R a ,

22) O(C═O)O b C 1 –C 10 alkyl,

23) O(C═O)O b C 3 –C 8 cycloalkyl,

24) O(C═O)O b aryl, and

25) O(C═O)O b -heterocycle,

R c is selected from:

1) H,

2) C 1 –C 10 alkyl,

3) aryl,

4) C 2 –C 10 alkenyl,

5) C 2 –C 10 alkynyl,

6) heterocyclyl,

7) C 3 –C 8 cycloalkyl,

8) C 1 –C 6 perfluoroalkyl,

said alkyl, cycloalkyl, aryl, heterocylyl, alkenyl, and alkynyl is optionally substituted with one or more substituents selected from R z , or

or a pharmaceutically acceptable salt or a stereoisomer thereof.

3. The compound according to claim 2 of the Formula B:

wherein:

a is 0 or 1;

b is 0 or 1;

m is 0, 1 or 2;

n is 0, 1, 2 or 3;

p is 0, 1 or 2;

r is 0 or 1;

s is 0 or 1;

u, v, w and x are independently selected from: CH and N, provided that only one of u, v, w and x may be N;

Q is selected from: —NR 5 R 6 , benzimidazolyl, benzimidazolonyl, quinolinyl and isoquinolinyl, said benzimidazolyl, benzimidazolonyl, quinolinyl and isoquinolinyl which are optionally substituted with one or two R z ;

R 1 is independently selected from:

1) (C═O) a O b C 1 –C 10 alkyl,

2) (C═O) a O b aryl,

3) C 2 –C 10 alkenyl,

4) C 2 –C 10 alkynyl,

5) (C═O) a O b heterocyclyl,

6) (C═O) a O b C 3 –C 8 cycloalkyl,

7) CO 2 H,

8) halo,

9) CN,

10) OH,

11) O b C 1 –C 6 perfluoroalkyl,

12) O a (C═O) b NR 5 R 6 ,

13) NR c (C═O)NR 5 R 6 ,

14) S(O) m R a ,

15) S(O) 2 NR 5 R 6 ,

16) NR c S(O) m R a ,

17) oxo,

18) CHO,

19) NO 2 ,

20) NR c (C═O)O b R a ,

21) O(C═O)O b C 1 –C 10 alkyl,

22) O(C═O)O b C 3 –C 8 cycloalkyl,

23) O(C═O)O b aryl, and

24) O(C═O)O b -heterocycle,

said alkyl, aryl, alkenyl, alkynyl, heterocyclyl, and cycloalkyl optionally substituted with one or more substituents selected from R z ;

R 2 is independently selected from:

1) (C═O) a O b C 1 –C 10 alkyl,

2) (C═O) a O b aryl,

3) C 2 –C 10 alkenyl,

4) C 2 –C 10 alkynyl,

5) (C═O) a O b heterocyclyl,

6) (C═O) a O b C 3 –C 8 cycloalkyl,

7) CO 2 H,

8) halo,

9) CN,

10) OH,

11) O b C 1 –C 6 perfluoroalkyl,

12) O a (C═O) b NR 5 R 6 ,

13) NR c (C═O)NR 5 R 6 ,

14) S(O) m R a ,

15) S(O) 2 NR 5 R 6 ,

16) NR c S(O) m R a ,

17) CHO,

18) NO 2 ,

19) NR c (C═O)O b R a ,

20) O(C═O)O b C 1 –C 10 alkyl,

21) O(C═O)O b C 3 –C 8 cycloalkyl,

22) O(C═O)O b aryl, and

23) O(C═O)O b -heterocycle,

said alkyl, aryl, alkenyl, alkynyl, heterocyclyl, and cycloalkyl optionally substituted with one, two or three substituents selected from R z ;

R 5 and R 6 are independently selected from:

1) H,

2) (C═O)O b R a ,

3) C 1 –C 10 alkyl,

4) aryl,

5) C 2 –C 10 alkenyl,

6) C 2 –C 10 alkynyl,

7) heterocyclyl,

8) C 3 –C 8 cycloalkyl,

9) SO 2 R a , and

10) (C═O)NR b 2 ,

said alkyl, cycloalkyl, aryl, heterocylyl, alkenyl, and alkynyl is optionally substituted with one or more substituents selected from R z , or

R z is selected from:

1) (C═O) r O s (C 1 –C 10 )alkyl,

2) O r (C 1 –C 3 )perfluoroalkyl,

3) (C 0 –C 6 )alkylene-S(O) m R a ,

4) oxo,

5) OH,

6) halo,

7) CN,

8) (C═O) r O s (C 2 –C 10 )alkenyl,

9) (C═O) r O s (C 2 –C 10 )alkynyl,

10) (C═O) r O s (C 3 –C 6 )cycloalkyl,

11) (C═O) r O s (C 0 –C 6 )alkylene-aryl,

12) (C═O) r O s (C 0 –C 6 )alkylene-heterocyclyl,

13) (C═O) r O s (C 0 –C 6 )alkylene-N(R b ) 2 ,

14) C(O)R a ,

15) (C 0 –C 6 )alkylene-CO 2 R a ,

16) C(O)H,

17) (C 0 –C 6 )alkylene-CO 2 H,

18) C(O)N(R b ) 2 ,

19) S(O) m R a ,

20) S(O) 2 N(R b ) 2 ,

21) NR c (C═O)O b R a ,

22) O(C═O)O b C 1 –C 10 alkyl,

23) O(C═O)O b C 3 –C 8 cycloalkyl,

24) O(C═O)O b aryl, and

25) O(C═O)O b -heterocycle,

R a is (C 1 –C 6 )alkyl, (C 3 –C 6 )cycloalkyl, aryl, or heterocyclyl; and

R b is H, (C 1 –C 6 )alkyl, aryl, heterocyclyl, (C 3 –C 6 )cycloalkyl, (C═O)OC 1 –C 6 alkyl, (C═O)C 1 –C 6 alkyl or S(O) 2 R a ;

R c is selected from:

1) H,

2) C 1 –C 10 alkyl,

3) aryl,

4) C 2 –C 10 alkenyl,

5) C 2 –C 10 alkynyl,

6) heterocyclyl,

7) C 3 –C 8 cycloalkyl,

8) C 1 –C 6 perfluoroalkyl,

said alkyl, cycloalkyl, aryl, heterocylyl, alkenyl, and alkynyl is optionally substituted with one or more substituents selected from R z , or

or a pharmaceutically acceptable salt or a stereoisomer thereof.

4. The compound according to claim 3 of the Formula C:

wherein

a is 0 or 1;

b is 0 or 1;

m is 0, 1 or 2;

n is 0, 1, 2 or 3;

p is 0, 1 or 2;

r is 0 or 1;

s is 0 or 1;

u, v, w and x are independently selected from: CH and N, provided that only one of u, v, w and x may be N;

Q is selected from: —NR 5 R 6 ,

R 1 is independently selected from:

1) (C═O) a O b C 1 –C 10 alkyl,

2) (C═O) a O b aryl,

3) C 2 –C 10 alkenyl,

4) C 2 –C 10 alkynyl,

5) (C═O) a O b heterocyclyl,

6) (C═O) a O b C 3 –C 8 cycloalkyl,

7) CO 2 H,

8) halo,

9) CN,

10) OH,

11) O b C 1 –C 6 perfluoroalkyl,

12) O a (C═O) b NR 5 R 6 ,

13) NR c (C═O)NR 5 R 6 ,

14) S(O) m R a ,

15) S(O) 2 NR 5 R 6 ,

16) NR c S(O) m R a ,

17) oxo,

18) CHO,

19) NO 2 ,

20) NR c (C═O)O b R a ,

21) O(C═O)O b C 1 –C 10 alkyl,

22) O(C═O)O b C 3 –C 8 cycloalkyl,

23) O(C═O)O b aryl, and

24) O(C═O)O b -heterocycle,

said alkyl, aryl, alkenyl, alkynyl, heterocyclyl, and cycloalkyl optionally substituted with one or more substituents selected from R z ;

R 2 is independently selected from:

1) C 1 –C 6 alkyl,

2) aryl,

3) heterocyclyl,

4) CO 2 H,

5) halo,

6) CN,

7) OH,

8) S(O) 2 NR 5 R 6 ,

said alkyl, aryl and heterocyclyl optionally substituted with one, two or three substituents selected from R z ;

R 5 and R 6 are independently selected from:

1) H,

2) (C═O)O b R a ,

3) C 1 –C 10 alkyl,

4) aryl,

5) C 2 –C 10 alkenyl,

6) C 2 –C 10 alkynyl,

7) heterocyclyl,

8) C 3 –C 8 cycloalkyl,

9) SO 2 R a , and

10) (C═O)NR b 2 ,

said alkyl, cycloalkyl, aryl, heterocylyl, alkenyl, and alkynyl is optionally substituted with one or more substituents selected from R z , or

R z is selected from:

1) (C═O) r O s (C 1 –C 10 )alkyl,

2) O r (C 1 –C 3 )perfluoroalkyl,

3) (C 0 –C 6 )alkylene-S(O) m R a ,

4) oxo,

5) OH,

6) halo,

7) CN,

8) (C═O) r O s (C 2 –C 10 )alkenyl,

9) (C═O) r O s (C 2 –C 10 )alkynyl,

10) (C═O) r O s (C 3 –C 6 )cycloalkyl,

11) (C═O) r O s (C 0 –C 6 )alkylene-aryl,

12) (C═O) r O s (C 0 –C 6 )alkylene-heterocyclyl,

13) (C═O) r O s (CO 0 –C 6 )alkylene-N(R b ) 2 ,

14) C(O)R a ,

15) (C 0 –C 6 )alkylene-CO 2 R a ,

16) C(O)H,

17) (C 0 –C 6 )alkylene-CO 2 H,

18) C(O)N(R b ) 2 ,

19) S(O) m R a , and

20) S(O) 2 N(R b ) 2 ,

21) NR c (C═O)O b R a ,

22) O(C═O)O b C 1 –C 10 alkyl,

23) O(C═O)O b C 3 –C 8 cycloalkyl,

24) O(C═O)O b aryl, and

25) O(C═O)O b -heterocycle,

R a is (C 1 –C 6 )alkyl, (C 3 –C 6 )cycloalkyl, aryl, or heterocyclyl; and

R b is H, (C 1 –C 6 )alkyl, aryl, heterocyclyl, (C 3 –C 6 )cycloalkyl, (C═O)OC 1 –C 6 alkyl, (C═O)C 1 –C 6 alkyl or S(O) 2 R a ;

R c is selected from:

1) H,

2) C 1 –C 10 alkyl,

3) aryl,

4) C 2 –C 10 alkenyl,

5) C 2 –C 10 alkynyl,

6) heterocyclyl,

7) C 3 –C 8 cycloalkyl,

8) C 1 –C 6 perfluoroalkyl,

said alkyl, cycloalkyl, aryl, heterocylyl, alkenyl, and alkynyl is optionally substituted with one or more substituents selected from R z , or

or a pharmaceutically acceptable salt or a stereoisomer thereof.

5. A compound which is selected from:

1-{1-[4-(3-phenylquinoxalin-2-yl)benzyl]piperidin-4-yl}-1,3-dihydro-2H-benzimidazol-2-one;

3-(4-{[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperdin-1-yl]methyl}phenyl)-2-phenylquinaxoline-6-carboxylic acid;

2-(4-{[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperdin-1-yl]methyl}phenyl)-3-phenylquinaxoline-6-carboxylic acid;

N-[3-(1H-imidazol-1-yl)propyl]-3-(4-{[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperdin-1-yl]methyl}phenyl)-2-phenylquinaxoline-6-carboxamide;

1-{1-[4-(3-phenylpyrido[3,4-b]pyrazin-2-yl)benzyl]piperidin-4-yl}-1,3-dihydro-2H-benzimidazol-2-one;

1-{1-[4-(2-phenylpyrido[3,4-b]pyrazin-3-yl)benzyl]piperidin-4-yl}-1,3-dihydro-2H-benzimidazol-2-one;

1-{1-[4-(2-phenylquinolin-3-yl)benzyl]piperdin-4-yl}-1,3-dihydro-2H-benzimidazol-2-one;

1-{1-[4-(6,7-diamino-3-phenylquinoxalin-2-yl)benzyl]piperidin-4-yl}-1,3-dihydro-2H-benzimidazol-2-one;

2-(4-{[3-(1H-indol-3-yl)pyrrolidin-1-yl]methyl}phenyl)-3-phenylquinoxaline;

1-(1-{4-[3-(2-aminophenyl)quinoxalin-2-yl]benzyl}piperidin-4-yl)-1,3-dihydro-2H-benzimidazol-2-one;

3,4-dichloro-N-{(3R)-1-[4-(3-phenylquinoxalin-2-yl)benzyl]pyrrolidin-3-yl}benzimide;

4-cyano-N-{(3R)-1-[4-(3-phenylquinoxalin-2-yl)benzyl]pyrrolidin-3-yl}benzimide;

2,6-difluoro-N-{(3R)-1-[4-(3-phenylquinoxalin-2-yl)benzyl]pyrrolidin-3-yl}benzimide;

N-{(3R)-1-[4-(3-phenylquinoxalin-2-yl)benzyl]pyrrolidin-3-yl}-3-(trifluoromethyl)benzimide;

2,5-difluoro-N-{(3R)-1-[4-(3-phenylquinoxalin-2-yl)benzyl]pyrrolidin-3-yl}benzimide;

3,5-difluoro-N-{(3R)-1-[4-(3-phenylquinoxalin-2-yl)benzyl]pyrrolidin-3-yl}benzimide;

N-{(3R)-1-[4-(3-phenylquinoxalin-2-yl)benzyl]pyrrolidin-3-yl}-1,3-thiazole-5-carboxamide;

(3R)-1-[4-(3-phenylquinoxalin-2-yl)benzyl]-3-[(1,3-thiazol-4-ylcarbonyl)amino]pyrrolidinium;

4-[({(3R)-1-[4-(3-phenylquinoxalin-2-yl)benzyl]pyrrolidin-3-yl}amino)carbonyl]-1,3-thiazolidin-3-ium;

N-{(3R)-1-[4-(7-amino-3-phenylquinoxalin-2-yl)benzyl]pyrrolidin-3-yl}-1,3-thiazole-5-carboxamide;

3-phenyl-2-[4-({(3R)-3-[(1,3-thiazol-5-ylcarbonyl)amino]pyrrolidin-1-yl}methyl)phenyl]quinoxaline-6-carboxylic acid;

2-phenyl-3-[4-({(3R)-3-[(1,3-thiazol-5-ylcarbonyl)amino]pyrrolidin-1-yl}methyl)phenyl]quinoxaline-6-carboxylic acid;

N-{(3R)-1-[4-(3-phenylpyrido[3,4-b]pyrazin-2-yl)benzyl]pyrrolidin-3-yl}-1,3-thiazole-5-carboxamide;

N-{(3R)-1-[4-(3-phenylpyrido[2,3-b]pyrazin-2-yl)benzyl]pyrrolidin-3-yl}-1,3-thiazole-5-carboxamide;

N-{(3R)-1-[4-(2-phenylpyrido[2,3-b]pyrazin-3-yl)benzyl]pyrrolidin-3-yl}-1,3-thiazole-5-carboxamide;

N-{(3R)-1-[4-(5-hydroxy-3-phenylquinoxalin-2-yl)benzyl]pyrrolidin-3-yl}-1,3-thiazole-5-carboxamide;

N-(3-methylphenyl)-N′-{1-[4-(3-phenylquinoxalin-2-yl)benzyl]azetidin-3-yl}urea;

N-(4-methoxyphenyl)-N′-{1-[4-(3-phenylquinoxalin-2-yl)benzyl]azetidin-3-yl}urea;

N-(3-methoxyphenyl)-N′-{1-[4-(3-phenylquinoxalin-2-yl)benzyl]azetidin-3-yl}urea;

methyl 3-{[({1-[4-(3-phenylquinoxalin-2-yl)benzyl]azetidin-3-yl}amino)carbonyl]amino}benzoate;

N-[4-(difluoromethoxy)phenyl]-N′-{1-[4-(3-phenylquinoxalin-2-yl)benzyl]azetidin-3-yl}urea;

2-(4-{[4-(2-methyl-1H-benzimidazol-1-yl)piperidin-1-yl]methyl}phenyl)-3-phenylquinoxalin-5-ol;

N 2 ,N 2 -dimethyl-N 1 -[3-(4-{[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]methyl}phenyl)-3-phenylquinoxalin-6-yl]glycinamide;

9-{1-[4-(3-phenylquinoxalin-2-yl)benzyl]piperidin-4-yl}-9H-purin-6-amine;

3-(4-{[4-(6-amino-9H-purin-9-yl)piperidin-1-yl]methyl}phenyl)-2-phenylquinoxalin-6-amine;

9-{1-[4-(6-chloro-3-phenylquinoxalin-2-yl)benzyl]piperidin-4-yl}-9H-purin-6-amine;

2-(4-{[4-(6-amino-9H-purin-9-yl)piperidin-1-yl]methyl}phenyl)-3-phenylquinoxalin-6-amine;

9-{1-[4-(7-chloro-3-phenylquinoxalin-2-yl)benzyl]piperidin-4-yl}-9H-purin-6-amine;

9-{1-[4-(3-phenylpyrido[3,4-b]pyrazin-2-yl)benzyl]piperidin-4-yl}-9H-purin-6-amine;

9-{1-[4-(3-phenylpyrido[2,3-b]pyrazin-2-yl)benzyl]piperidin-4-yl}-9H-purin-6-amine;

9-{1-[4-(2-phenylpyrido[2,3-b]pyrazin-3-yl)benzyl]piperidin-4-yl}-9H-purin-6-amine;

2-(4-{[4-(6-amino-9H-purin-9-yl)piperidin-1-yl]methyl}phenyl)-3-phenylquinoxalin-5-ol;

2-(4-{[4-(6-amino-9H-purin-9-yl)piperidin-1-yl]methyl}phenyl)-3-phenylquinoxaline-6-carboxylic acid;

3-(4-{[4-(6-amino-9H-purin-9-yl)piperidin-1-yl]methyl}phenyl)-2-phenylquinoxaline-6-carboxylic acid;

2-(4-{[4-(3H-imidazo[4,5-b]pyridin-3-yl)piperidin-1-yl]methyl}phenyl)-3-phenylquinoxaline;

2-(4-{[4-(3H-imidazo[4,5-b]pyridin-3-yl)piperidin-1-yl]methyl}phenyl)-3-phenylquinoxalin-6-amine;

3-(4-{[4-(3H-imidazo[4,5-b]pyridin-3-yl)piperidin-1-yl]methyl}phenyl)-2-phenylquinoxalin-6-amine;

2-(4-{[4-(3H-imidazo[4,5-b]pyridin-3-yl)piperidin-1-yl]methyl}phenyl)-3-phenylpyrido[2,3-b]pyrazine;

1-{1-[4-(3-phenylquinolin-2-yl)benzyl]piperidin-4-yl}-1,3-dihydro-2H-benzimidazol-2-one;

1-(1-{4-[3-phenyl-6-(1H-tetrazol-5-yl)quinoxalin-2-yl]benzyl}piperidin-4-yl)-1,3-dihydro-2H-benzimidazol-2-one;

1-(1-{4-[3-phenyl-7-(1H-tetrazol-5-yl)quinoxalin-2-yl]benzyl}piperidin-4-yl)-1,3-dihydro-2H-benzimidazol-2-one;

9-(1-{4-[3-phenyl-7-(1H-tetrazol-5-yl)quinoxalin-2-yl]benzyl}piperidin-4-yl)-9H-purin-6-amine;

9-(1-{4-[3-phenyl-6-(1H-tetrazol-5-yl)quinoxalin-2-yl]benzyl}piperidin-4-yl)-9H-purin-6-amine;

N 2 ,N 2 -dimethyl-N 1 -[2-(4-{[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]methyl}phenyl)-3-phenylquinoxalin-6-yl]glycinamide;

N 2 ,N 2 -dimethyl-N 1 -[3-(4-{[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]methyl}phenyl)-3-phenylquinoxalin-6-yl]glycinamide;

1-{1-[4-(2-amino-4-hydroxy-7-phenylpteridin-6-yl)benzyl]piperidin-4-yl}-1,3-dihydro-2H-benzimidazol-2-one;

N-[2-(diethylamino)ethyl]-2-(4-{[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]methyl}phenyl)-3-phenylquinoxaline-6-carboxamide;

N-[2-(diethylamino)ethyl]-3-(4-{[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]methyl}phenyl)-2-phenylquinoxaline-6-carboxamide;

2-deoxy-2-({[2-(4-{[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]methyl}phenyl)-3-phenylquinoxalin-6-yl]carbonyl}amino)-D-arabino-hexopyranose;

2-deoxy-2-({[3-(4-{[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]methyl}phenyl)-2-phenylquinoxalin-6-yl]carbonyl}amino)-D-arabino-hexopyranose;

2-(4-{[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]methyl}phenyl)-3-phenylquinoxalin-6-yl 2-(acetylamino)-2-deoxy-D-glucopyranoside;

3-(4-{[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]methyl}phenyl)-2-phenylquinoxalin-6-yl 2-(acetylamino)-2-deoxy-D-glucopyranoside;

3-(4-{[4-hydroxy-4-phenylpiperdin-1-yl]methyl}phenyl)-2-phenylquinaxoline;

3-(4-{[4-(quinazolin-2-on-3-yl)piperdin-1-yl]methyl}phenyl)-2-phenylquinaxoline;

3-(4-{[4-(pyrid-2-yl)piperdin-1-yl]methyl}phenyl)-2-phenylquinaxoline;

3-(4-{[3-(benzimidazol-2-yl)piperdin-1-yl]methyl}phenyl)-2-phenylquinaxoline;

2-(4-{[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperdin-1-yl]methyl}phenyl)-3-phenyl-6-methylquinaxoline;

2-(4-{[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperdin-1-yl]methyl}phenyl)-3-phenyl-6-chloroquinaxoline;

2-(4-{[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperdin-1-yl]methyl}phenyl)-3-phenyl-6-(1-acetylaminoprop-2-yl)quinaxoline;

2-(4-{[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperdin-1-yl]methyl}phenyl)-3-phenyl-6-methylsulfonylquinaxoline;

N,N-dimethyl-2-(4-{[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperdin-1-yl]methyl}phenyl)-3-phenylquinaxoline-6-sulfonamide;

2-(4-{[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperdin-1-yl]methyl}phenyl)-3-phenylquinaxoline-6-sulfonamide;

N-[3-(1H-Imidazol-1-yl)propyl]-2-(4-{[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperdin-1-yl]methyl}phenyl)-3-phenylquinaxoline-6-carboxamide;

Ethyl 2-(4-{[4-(2-Oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperdin-1-yl]methyl}phenyl)-3-phenylquinaxoline-6-carboxylate;

N-[3-(2-hydroxyethyl]-2-(4-{[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperdin-1-yl]methyl}phenyl)-3-phenylquinaxoline-6-carboxamide;

N-[3-(2-phenyl-2-hydroxyethyl]-2-(4-{[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperdin-1-yl]methyl}phenyl)-3-phenylquinaxoline-6-carboxamide;

2-(4-{[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperdin-1-yl]methyl}phenyl)-3-phenyl-6-fluoroquinaxoline;

2-(4-{[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperdin-1-yl]methyl}phenyl)-3-phenyl-6-cyanoquinaxoline;

N-[2-(diethylamino)ethyl]-2-(4-{[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperdin-1-yl]methyl}phenyl)-3-phenylquinaxoline-6-carboxamide;

N-(5-hydroxypentyl)-2-(4-{[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperdin-1-yl]methyl}phenyl)-3-phenylquinaxoline-6-carboxamide;

N-[3-(dimethylamino)-2,2-dimethylpropyl]-2-(4-{[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperdin-1-yl]methyl}phenyl)-3-phenylquinaxoline-6-carboxamide;

N-[3-hydroxy-2,2-dimethylpropyl]-2-(4-{[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperdin-1-yl]methyl}phenyl)-3-phenylquinaxoline-6-carboxamide;

2-(4-{[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperdin-1-yl]methyl}phenyl)-3-phenylquinaxoline-6-methylsulfonamide;

2-(4-{[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperdin-1-yl]methyl}phenyl)-3-phenyl-6-methoxyquinaxoline;

2-(4-{[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperdin-1-yl]methyl}phenyl)-3-phenyl-6-nitroquinaxoline;

2-(4-{[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperdin-1-yl]methyl}phenyl)-3-phenyl-6-trifluoromethylquinaxoline;

2-(4-{[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperdin-1-yl]methyl}phenyl)-3-phenyl-6-aminoquinaxoline;

3-(4-{[4-(2-Oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperdin-1-yl]methyl}phenyl)-2-phenylquinaxoline-6-carboxylic acid;

3-(4-{[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperdin-1-yl]methyl}phenyl)-2-phenyl-6-methylquinaxoline;

3-(4-{[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperdin-1-yl]methyl}phenyl)-2-phenyl-6-chloroquinaxoline;

N,N-dimethyl-3-(4-{[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperdin-1-yl]methyl}phenyl)-2-phenylquinaxoline-6-sulfonamide;

3-(4-{[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperdin-1-yl]methyl}phenyl)-2-phenylquinaxoline-6-sulfonamide;

N-[3-(1H-Imidazol-1-yl)propyl]-3-(4-{[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperdin-1-yl]methyl}phenyl)-2-phenylquinaxoline-6-carboxamide;

Ethyl 3-(4-{[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperdin-1-yl]methyl}phenyl)-2-phenylquinaxoline-6-carboxylate;

N-[3-(2-hydroxyethyl]-3-(4-{[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperdin-1-yl]methyl}phenyl)-2-phenylquinaxoline-6-carboxamide;

N-[3-(2-phenyl-2-hydroxyethyl]-3-(4-{[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperdin-1-yl]methyl}phenyl)-2-phenylquinaxoline-6-carboxamide;

3-(4-{[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperdin-1-yl]methyl}phenyl)-2-phenyl-6-fluoroquinaxoline;

3-(4-{[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperdin-1-yl]methyl}phenyl)-2-phenyl-6-cyanoquinaxoline;

N-[2-(diethylamino)ethyl]-3-(4-{[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperdin-1-yl]methyl}phenyl)-2-phenylquinaxoline-6-carboxamide;

N-(5-hydroxypentyl)-3-(4-{[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperdin-1-yl]methyl}phenyl)-2-phenylquinaxoline-6-carboxamide;

N-[3-(dimethylamino)-2,2-dimethylpropyl]-3-(4-{[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperdin-1-yl]methyl}phenyl)-2-phenylquinaxoline-6-carboxamide;

N-[3-hydroxy-2,2-dimethylpropyl]-3-(4-{[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperdin-1-yl]methyl}phenyl)-2-phenylquinaxoline-6-carboxamide;

3-(4-{[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperdin-1-yl]methyl}phenyl)-2-phenylquinaxoline-6-methylsulfonamide;

3-(4-{[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperdin-1-yl]methyl}phenyl)-2-phenyl-6-methoxyquinaxoline;

3-(4-{[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperdin-1-yl]methyl}phenyl)-2-phenyl-6-nitroquinaxoline;

3-(4-{[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperdin-1-yl]methyl}phenyl)-2-phenyl-6-trifluoromethylquinaxoline;

3-(4-{[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperdin-1-yl]methyl}phenyl)-2-phenyl-6-aminoquinaxoline;

7-chloro-3-(4-{[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperdin-1-yl]methyl}phenyl)-2-phenylquinaxoline-6-sulfonamide;

7-methyl-2-(4-{[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperdin-1-yl]methyl}phenyl)-3-phenylquinaxoline-6-carboxamide;

6-chloro-7-fluoro-3-(4-{[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperdin-1-yl]methyl}phenyl)-2-phenylquinaxoline;

6,7-dichloro-3-(4-{[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperdin-1-yl]methyl}phenyl)-2-phenylquinaxoline;

7-chloro-2-(4-{[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperdin-1-yl]methyl}phenyl)-3-phenylquinaxoline-6-sulfonamide;

7-methyl-3-(4-{[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperdin-1-yl]methyl}phenyl)-2-phenylquinaxoline-6-carboxamide;

6-chloro-7-fluoro-2-(4-{[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperdin-1-yl]methyl}phenyl)-3-phenylquinaxoline;

6,7-dichloro-2-(4-{[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperdin-1-yl]methyl}phenyl)-3-phenylquinaxoline;

N-[2-(4-{[4-(benzimidazol-2-yl)piperdin-1-yl]methyl}phenyl)-3-phenylquinaxolin-6-yl]methylsulfonamide;

2-(4-{[4-(benzimidazol-2-yl)piperdin-1-yl]methyl}phenyl)-3-phenylquinaxoline-6-carboxylic acid;

3-(4-{[4-(benzimidazol-2-yl)piperdin-1-yl]methyl}phenyl)-2-phenylquinaxoline-6-carboxylic acid;

7-methyl-2-(4-{[4-(benzimidazol-2-yl)piperdin-1-yl]methyl}phenyl)-3-phenylquinaxoline-6-carboxamide;

7-methyl-3-(4-{[4-(benzimidazol-2-yl)piperdin-1-yl]methyl}phenyl)-2-phenylquinaxoline-6-carboxamide;

7-chloro-2-(4-{[4-(benzimidazol-2-yl)piperdin-1-yl]methyl}phenyl)-3-phenylquinaxoline-6-sulfonamide;

7-chloro-3-(4-{[4-(benzimidazol-2-yl)piperdin-1-yl]methyl}phenyl)-2-phenylquinaxoline-6-sulfonamide;

N-(2-hydroxyethyl)-7-methyl-2-(4-{[4-(benzimidazol-2-yl)piperdin-1-yl]methyl}phenyl)-3-phenylquinaxoline-6-carboxamide;

2-(4-{[4-(benzimidazol-2-yl)piperdin-1-yl]methyl}phenyl)-3-phenyl-6-methoxyquinaxoline;

3-(4-{[4-(benzimidazol-2-yl)piperdin-1-yl]methyl}phenyl)-2-phenyl-6-methoxyquinaxoline;

2-(4-{[4-(benzimidazol-2-yl)piperdin-1-yl]methyl}phenyl)-3-phenyl-6-fluoroquinaxoline;

3-(4-{[4-(benzimidazol-2-yl)piperdin-1-yl]methyl}phenyl)-2-phenyl-6-fluoroquinaxoline;

2-(4-{[4-(benzimidazol-2-yl)piperdin-1-yl]methyl}phenyl)-3-phenyl-6-cyanoquinaxoline;

3-(4-{[4-(benzimidazol-2-yl)piperdin-1-yl]methyl}phenyl)-2-phenyl-6-cyanoquinaxoline;

N-isopropyl-N′-({1-[4-(3-phenylquinoxalin-2-yl)benzyl]piperidin-3-yl}methyl)urea;

N-(3-fluorophenyl)-N′-({1-[4-(3-phenylquinoxalin-2-yl)benzyl]piperidin-3-yl}methyl)urea;

N-phenyl-N′-({1-[4-(3-phenylquinoxalin-2-yl)benzyl]piperidin-3-yl}methyl)urea;

N-(4-bromobenzyl)-N′-({1-[4-(3-phenylquinoxalin-2-yl)benzyl]piperidin-3-yl}methyl)urea;

N-({1-[4-(3-phenylquinoxalin-2-yl)benzyl]piperidin-3-yl}methyl)benzenesulfonamide;

N-({1-[4-(3-phenylquinoxalin-2-yl)benzyl]piperidin-3-yl}methyl)-4-bromobenzenesulfonamide;

N-({1-[4-(3-phenylquinoxalin-2-yl)benzyl]piperidin-3-yl}methyl)benzylsulfonamide;

N-({1-[4-(3-phenylquinoxalin-2-yl)benzyl]piperidin-3-yl}methyl)-3,4-dimethoxybenzenesulfonamide;

N-({1-[4-(3-phenylquinoxalin-2-yl)benzyl]piperidin-3-yl}methyl)thien-2-ylsulfonamide;

N-({1-[4-(3-phenylquinoxalin-2-yl)benzyl]piperidin-3-yl}methyl)2,2,2-trifluoroethylsulfonamide;

N-({1-[4-(3-phenylquinoxalin-2-yl)benzyl]piperidin-3-yl}methyl)quinolin-7-ylsulfonamide;

4-phenyl-1-{1-[4-(3-phenylquinoxalin-2-yl)benzyl]piperidin-4yl}-1,3-dihydro-2H-imidazol-2-one;

1-{1-[4-(3-phenylquinoxalin-2-yl)benzyl]pyrrolidin-4-yl}-1,3-dihydro-2H-triazol-2-one;

N-(1-[4-(3-phenylquinoxalin-2-yl)benzyl]piperidin-3-yl)1,2,3,4,5-trifluorophenylsulfonamide;

N-(1-[4-(3-phenylquinoxalin-2-yl)benzyl]piperidin-3-yl)-4-acetamidophenylsulfonamide;

N-(1-[4-(3-phenylquinoxalin-2-yl)benzyl]piperidin-3-yl)-3-chloropropylsulfonamide;

N-(1-[4-(3-phenylquinoxalin-2-yl)benzyl]piperidin-3-yl)-4-chloroophenylsulfonamide;

N-(1-[4-(3-phenylquinoxalin-2-yl)benzyl]piperidin-3-yl)butylsulfonamide;

N-(1-[4-(3-phenylquinoxalin-2-yl)benzyl]piperidin-3-yl)methylsulfonamide;

N-(1-[4-(3-phenylquinoxalin-2-yl)benzyl]piperidin-3-yl)ethylsulfonamide;

1-{1-[4-(2-phenylbenzo[f]quinoxalin-3-yl)benzyl]piperidin-4-yl}-1,3-dihydro-2H-benzimidazol-2-one;

1-{1-[4-(3-phenylbenzo[f]quinoxalin-2-yl)benzyl]piperidin-4-yl}-1,3-dihydro-2H-benzimidazol-2-one;

Ethyl 2-(4-{[4-(2-Oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperdin-1-yl]methyl}phenyl)-3-phenylquinaxoline-8-carboxylate;

Ethyl 2-(4-{[4-(2-Oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperdin-1-yl]methyl}phenyl)-3-phenylquinaxoline-5-carboxylate;

2-{1-[4-(3-phenylpyrido[3,4-b]pyrazin-2-yl)benzyl]piperidin-4-yl}benzimidazole;

2-{1-[4-(3-phenylpyrido[4,3-b]pyrazin-2-yl)benzyl]piperidin-4-yl}benzimidazole;

2-{1-[4-(3-phenylpyrido[2,3-b]pyrazin-2-yl)benzyl]piperidin-4-yl}benzimidazole;

2-{1-[4-(3-phenylpyrido[3,2-b]pyrazin-2-yl)benzyl]piperidin-4-yl}benzimidazole;

1-[1-(4-{6-[(4-methylpiperazin-1-yl)carbonyl]-3-phenylquinoxalin-2-yl}benzyl)piperidin-4-yl]-1,3-dihydro-2H-benzimidazol-2-one;

N-[4-(aminosulfonyl)benzyl]-2-(4-{[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl]methyl}phenyl)-3-phenylquinoxaline-6-carboxamide;

1-{1-[4-(6-benzoyl-3-phenylquinoxalin-2-yl]benzyl)piperidin-4-yl}-1,3-dihydro-2H-benzimidazol-2-one;

1-[1-(4-{6-[(4-aminophenyl)sulfonyl]-3-phenylquinoxalin-2-yl}benzyl)piperidin-4-yl]-1,3-dihydro-2H-benzimidazol-2-one;

N-{2-[3-(4-{[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]methyl}phenyl)-2-phenylquinoxalin-6-yl]ethyl}acetamide;

1-(1-{4-[7-(methylsulfonyl)-3-phenylquinoxalin-2-yl]benzyl}piperidin-4-yl)-1,3-dihydro-2H-benzimidazol-2-one;

N-{2-[2-(4-{[4-(benzimidazol-2-yl)piperidin-1-yl]methyl}phenyl)-3-phenylquinoxalin-6-yl]ethyl}acetamide;

1-{1-[4-(6-benzoyl-3-phenylquinoxalin-2-yl]benzyl)piperidin-4-yl}-1,3-dihydro-2H-benzimidazol-2-one;

1-{1-[4-(6-benzoyl-2-phenylquinoxalin-3-yl]benzyl)piperidin-4-yl}-1,3-dihydro-2H-benzimidazol-2-one;

1-[1-(4-{7-[(4-aminophenyl)sulfonyl]-3-phenylquinoxalin-2-yl}benzyl)piperidin-4-yl]-1,3-dihydro-2H-benzimidazol-2-one;

1-{1-[4-(7-benzoyl-3-phenylquinoxalin-2-yl]benzyl)piperidin-4-yl}-1,3-dihydro-2H-benzimidazol-2-one;

1-[1-(4-{7-[(4-methylpiperazin-1-yl)carbonyl]-3-phenylquinoxalin-2-yl}benzyl)piperidin-4-yl]-1,3-dihydro-2H-benzimidazol-2-one;

N-[4-(aminosulfonyl)benzyl]-3-(4-{[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl]methyl}phenyl)-2-phenylquinoxaline-6-carboxamide;

N-{2-[2-(4-{[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]methyl}phenyl)-3-phenylquinoxalin-6-yl]ethyl}acetamide;

1-(1-{4-[6-(methylsulfonyl)-3-phenylquinoxalin-2-yl]benzyl}piperidin-4-yl)-1,3-dihydro-2H-benzimidazol-2-one;

1-(1-{4-[6-(1-methyl-1H-tetrazol-5-yl)-3-phenylquinoxalin-2-yl]benzyl}piperidin-4-yl)-1,3-dihydro-2H-benzimidazol-2-one;

1-(1-{4-[7-(1-methyl-1H-tetrazol-5-yl)-3-phenylquinoxalin-2-yl]benzyl}piperidin-4-yl)-1,3-dihydro-2H-benzimidazol-2-one;

1-(1-{4-[6-(2-methyl-2H-tetrazol-5-yl)-3-phenylquinoxalin-2-yl]benzyl}piperidin-4-yl)-1,3-dihydro-2H-benzimidazol-2-one;

1-(1-{4-[7-(2-methyl-2H-tetrazol-5-yl)-3-phenylquinoxalin-2-yl]benzyl}piperidin-4-yl)-1,3-dihydro-2H-benzimidazol-2-one;

2-(4-{[4-(1H-indol-1-yl)piperidin-1-yl]methyl}phenyl)-6-(2-methyl-2H-tetrazol-5-yl)-3-phenylquinoxaline;

3-(4-{[4-(1H-indol-1-yl)piperidin-1-yl]methyl}phenyl)-6-(2-methyl-2H-tetrazol-5-yl)-2-phenylquinoxaline;

2-(4-{[4-(2-methyl-1H-benzimidazol-1-yl)piperidin-1-yl]methyl}phenyl)-6-(1-methyl-1H-tetrazol-5-yl)-3-phenylquinoxaline;

2-(4-{[4-(2-methyl-1H-benzimidazol-1-yl)piperidin-1-yl]methyl}phenyl)-6-(2-methyl-2H-tetrazol-5-yl)-3-phenylquinoxaline;

2-(4-{[4-(2-methyl-1H-benzimidazol-1-yl)piperidin-1-yl]methyl}phenyl)-3-phenyl-1,8-naphthyridine;

1-(1-{4-[6-(2-methyl-2H-tetrazol-5-yl)-3-phenylquinolin-2-yl]benzyl}piperidin-4-yl)-1,3-dihydro-2H-benzimidazol-2-one;

1-(1-{4-[6-(2-methyl-2H-tetrazol-5-yl)-3-phenylquinolin-2-yl]benzyl}piperidin-4-yl)-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

9-(1-{4-[6-(2-methyl-2H-tetrazol-5-yl)-3-phenylquinolin-2-yl]benzyl}piperidin-4-yl)-9H-purin-6-amine;

9-{1-[4-(3-phenyl-1,8-naphthyridin-2-yl)benzyl]piperidin-4-yl}-9H-purin-6-amine;

1-{1-[4-(3-phenyl-1,8-naphthyridin-2-yl)benzyl]piperidin-4-yl}-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one;

1-{1-[4-(3-phenyl-1,8-naphthyridin-2-yl)benzyl]piperidin-4-yl}-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one 4-oxide;

1-{1-[4-(3-Phenyl-1,8-naphthyridin-2-yl)benzyl]piperidin-4-yl}-1,3-dihydro-2H-benzimidazol-2-one;

2-(4-{[4-(2-methyl-1H-benzimidazol-1-yl)piperidin-1-yl]methyl}phenyl)-3-phenylquinoxaline-6-carboxylic acid;

3-(4-{[4-(2-methyl-1H-benzimidazol-1-yl)piperidin-1-yl]methyl}phenyl)-2-phenylquinoxaline-6-carboxylic acid;

N-[2-(diethylamino)ethyl]-3-(4-{[4-(2-methyl-1H-benzimidazol-1-yl)piperidin-1-yl]methyl}phenyl)-2-phenylquinoxaline-6-carboxamide;

N-(2-hydroxyethyl)-3-(4-{[4-(2-methyl-1H-benzimidazol-1-yl)piperidin-1-yl]methyl}phenyl)-2-phenylquinoxaline-6-carboxamide;

N-methyl-3-(4-{[4-(2-methyl-1H-benzimidazol-1-yl)piperidin-1-yl]methyl}phenyl)-2-phenylquinoxaline-6-carboxamide;

N-[3-(1H-imidazol-1-yl)propyl]-3-(4-{[4-(2-methyl-1H-benzimidazol-1-yl)piperidin-1-yl]methyl}phenyl)-2-phenylquinoxaline-6-carboxamide;

2-(4-{[4-(6-fluoro-1H-benzimidazol-2-yl)piperidin-1-yl]methyl}phenyl)-3-phenylquinoxaline-6-carboxylic acid;

3-(4-{[4-(6-fluoro-1H-benzimidazol-2-yl)piperidin-1-yl]methyl}phenyl)-2-phenylquinoxaline-6-carboxylic acid;

N-[2-(diethylamino)ethyl]-3-(4-{[4-(6-fluoro-1H-benzimidazol-2-yl)piperidin-1-yl]methyl}phenyl)-2-phenylquinoxaline-6-carboxamide;

7-bromo-2-(4-{[4-(6-fluoro-1H-benzimidazol-2-yl)piperidin-1-yl]methyl}phenyl)-6-methyl-3-phenylpyrido[2,3-b]pyrazine;

7-bromo-3-(4-{[4-(6-fluoro-1H-benzimidazol-2-yl)piperidin-1-yl]methyl}phenyl)-2-phenylpyrido[2,3-b]pyrazine;

7-bromo-6-methyl-2-(4-{[4-(2-methyl-1H-benzimidazol-1-yl)piperidin-1-yl]methyl}phenyl)-3-phenylpyrido[2,3-b]pyrazine;

7-bromo-3-(4-{[4-(2-methyl-1H-benzimidazol-1-yl)piperidin-1-yl]methyl}phenyl)-2-phenylpyrido[2,3-b]pyrazine;

1-{1-[4-(4-amino-6-phenylpyrido[2,3-d]pyrimidin-7-yl)benzyl]piperidin-4-yl}-1,3-dihydro-2H-benzimidazol-2-one;

1-{1-[4-(4-amino-2-hydroxy-6-phenylpyrido[2,3-d]pyrimidin-7-yl)benzyl]piperidin-4-yl}-1,3-dihydro-2H-benzimidazol-2-one; and

1-{1-[4-(2,4-diamino-6-phenylpyrido[2,3-d]pyrimidin-7-yl)benzyl]piperidin-4-yl}1,3-dihydro-2H-benzimidazol-2-one;

or a pharmaceutically acceptable salt or a stereoisomer thereof.

6. The compound according to claim 5 which is the TFA salt of a compound selected from: