Stabilized ascorbic acid derivatives
An ascorbic acid derivative, which is a compound represented by the following general formula (1) or a salt thereof: [Chemical Formula 11] (1)(wherein X and Y each represents H or a protective group for OH, R 1 and R 2 each represents an alkyl group having from 1 to 19 carbon atoms, which may be linear or branched, and the total number of carbon atoms in R 1 R 2 is an integer of 5 to 22).
1. An ascorbic acid derivative, which is a compound represented by the following general formula (1) or a salt thereof:
(wherein X and Y each represents H or a protective group for OH, R 1 and R 2 each represents an alkyl group having from 1 to 19 carbon atoms, which may be linear or branched, and the total number of carbon atoms in R 1 and R 2 is an integer of 5 to 22).
2. The ascorbic acid derivative according to claim 1 , which is a salt with one or more metal selected from the group consisting of alkali metal, alkaline earth metal, aluminum, iron, zinc and bismuth.
3. The ascorbic acid derivative according to claim 1 , which is a salt with ammonia, monoethanolamine, diethanolamine, triethanolamine, dicyclohexylamine or 2-amino-1-methylpropanol.
4. The ascorbic acid derivative according to any one of claims 1 to 3 , wherein the total number of carbon atoms in R 1 and R 2 of the general formula (1) is an integer of 8 to 18.
5. The ascorbic acid derivative according to claim 4 , wherein R 1 and R 2 of the general formula (1) are a linear alkyl group, and the total number of carbon atoms in the linear alkyl groups of R 1 and R 2 is 14 or 16.
6. The ascorbic acid derivative according to claim 5 , wherein in the general formula (1), R 1 is n-C 9 H 19 and R 2 is n-C 7 H 15 ; or R 1 is n-C 8 H 17 and R 2 is n-C 6 H 13 .
7. A process for producing an ascorbic acid derivative according to claim 1 , comprising a step of reacting a compound represented by the following general formula (2) and/or a salt thereof:
(wherein X and Y each represents H or a protective group for OH), with at least one selected from fatty acid, fatty acid salt, fatty acid ester, fatty acid halide, and/or fatty acid anhydride.
8. The process for producing an ascorbic acid derivative according to claim 7 , wherein the reaction is performed in the presence of a condensing agent and/or dehydrating agent.
9. The process for producing an ascorbic acid derivative according to claim 8 , wherein the dehydrating agent is sulfuric acid.
10. The process for producing an ascorbic acid derivative according to any one of claims 7 , wherein the reaction is conducted in a solvent selected from the group consisting of: water, acetone, dioxane, toluene, ethylbenzene, methyl-tert-butyl ether and sulfuric acid.
11. A vitamin C preparation comprising a therapeutically effective amount of the ascorbic acid derivative according to claim 1 as an effective ingredient.
12. A composition comprising a therapeutically effective amount of the ascorbic acid derivative according to claim 1 , in the form of a medical or pharmaceutical preparation, an agrochemical preparation or an animal drug preparation.
13. A composition comprising a therapeutically effective amount of the ascorbic acid derivative according to claim 1 , in the form of a food or feed additive.